Dopamine and Hypertension
DA may be an important factor in regulating blood pressure through central and/or peripheral dopaminergic mechanisms. Decreased central dopaminergic activity was postulated by Stumpe et al. (1977), who suggested that hypertensive patients exhibit an enhanced release of prolactin. A depressor response to an intracerebroventicular injection of DA was by Kondo et al. (1981). In contrast, Kawabe et al. (1986) have suggested that the central dopaminergic mechanisms in cardiovascular regulation are negligible, with the evidence that intracerebroventricular injections of DA or a DA antagonist, metoclopramide, have no effect on the regulation of blood pressure. Therefore, the role of central dopaminergic mechanisms in blood pressure regulation is, at present, unclear.
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