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Peripheral Actions of Dopamine pp 24–40Cite as

Dopamine Storage in Sympathetic Nerves

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Abstract

In recent years a considerable amount of information has been obtained on the sources and actions of DA in peripheral tissues. Most of the knowledge we have now on DA has been shown to be extremely useful in the clarification of certain aspects of cardiovascular and renal physiology, as well as for the understanding of the pathophysiology of disorders affecting those systems, such as hypertension and heart failure (Clark, 1985). Also, it should be stressed that the development and use of new drugs acting via the activation or blockade of DA receptors in conditions such as hypertension and heart failure are in part related to the recent advances made in the research on the actions of DA and its role in sympathetic neurotransmission (Goldberg, 1972; Brodde, 1982; Lokhandwala and Barrett, 1982; Willems et al., 1985).

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References

  • Andersson, K.-E. (1986). Adrenergic mechanisms in congestive heart failure. Acta Med. Scand., Suppl.707, 37–44

    CAS  Google Scholar 

  • Axelrod, J. (1976). Catecholamines and hypertension. Clin. Sci. Molec. Med., 51, 415S–421S

    Google Scholar 

  • Bell, C. (1982). Dopamine as a post-ganglionic autonomic transmitter. Neuroscience, 7, 1–8

    Article  PubMed  CAS  Google Scholar 

  • Bell, C. (1987). Dopamine: precursor or transmitter in sympathetically-innervated tissues? Blood Vessels, 24, 234–239

    PubMed  CAS  Google Scholar 

  • Bell, C. and Gillespie, J. S. (1981). Dopamine and noradrenaline levels in peripheral tissues of several mammalian species. J. Neurochem., 36, 703–706

    Article  PubMed  CAS  Google Scholar 

  • Bell, C., Gillespie, J. S. and Macrae, I. M. (1984). Release of noradrenaline and dopamine by nerve stimulation in the guinea-pig and rat vas deferens. Br. J. Pharmac., 81, 563–569

    Article  CAS  Google Scholar 

  • Branco, D. and Osswald, W. (1986). Ouabain-induced efflux of catecholamines and metabolites from blood vessels of normotensive and hypertensive dogs. In Erdmann, E., Greef, K. and Skou, J. C. (Eds.), Cardiac Glycosides 1785–1985, Steinkopf Verlag, Darmstadt, New York, pp. 367–376

    Google Scholar 

  • Brodde, O.-E. (1982). Vascular dopamine receptors: Demonstration and characterisation in vitro studies. Life Sci., 31, 289–306

    Article  PubMed  CAS  Google Scholar 

  • Caramona, M. M. and Soares-da-Silva, P. (1985). The effects of chemical sympathectomy on dopamine and noradrenaline and adrenaline content in some peripheral tissues. Br. J. Pharmac., 86, 351–356

    Article  CAS  Google Scholar 

  • Clark, B. J. (1985). The role of dopamine in the periphery. In Fluckiger, E. and Müller, E. E. and Thorner, M. O. (Eds.), The Dopaminergic System, Springer-Verlag, Berlin, pp. 27–39

    Chapter  Google Scholar 

  • Costa, E., Green, A. R., Koslow, S. H., Revuelta, A. V. and Wang, C. (1972). Dopamine and norepinephrine in noradrenergic axons: A study of their precursor product relationship by mass fragmentography and radiochemistry. Pharmac. Rev., 24, 167–190

    CAS  Google Scholar 

  • deChamplain, J., Farley, L., Cousineau, D. and Van Amerigen, M.-R. (1976). Circulating catecholamine levels in human and experimental hypertension. Circulation Res., 38, 109–114

    Article  CAS  Google Scholar 

  • Esplugues, J. V., Caramona, M. M., Moura, D. and Soares-da-Silva, P. (1985). Effects of chemical sympathectomy on dopamine and noradrenaline content of the dog gastrointestinal tract. J. Autonom. Pharmac., 5, 189–195

    Article  CAS  Google Scholar 

  • Gianutsos, G. and Moore, K. E. (1978). Epinephrine contents of sympathetic ganglia and brain regions of spontaneously hypertensive rats of different ages. Proc. Soc. Exp. Biol. Med., 158, 45–49

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, L. I. (1972). Cardiovascular and renal actions of dopamine: potential and clinical applications. Pharmac. Rev., 24, 1–29

    CAS  Google Scholar 

  • Goldstein, M. (1966). Inhibition of norepinephrine biosynthesis at the dopamine-β-hydroxylase stage. Pharmac Rev., 18, 96–102

    Google Scholar 

  • Graffner, H., Ekelund, M., Hakånson, R. and Rosengren, E. (1985). Effect of different denervation procedures in the gut. Scand. J. Gastroenterol., 20, 1276–1280

    Article  PubMed  CAS  Google Scholar 

  • Grobecker, H., Saavedra, J. M. and Weise, V. K. (1982). Biosynthetic enzyme activities and catecholamines in adrenals of genetic and experimental hypertensive rats. Circulation Res., 50, 742–746

    Article  PubMed  CAS  Google Scholar 

  • Judy, W. V., Watanabe, A. M., Henry, D. P., Besch, H. R. jr., Murphy, W. R. and Hockel, G. M. (1976). Sympathetic nerve activity: Role in regulation of blood pressure in the spontaneously hypertensive rat. Circulation Res., 38, II-21–II-29

    Article  PubMed  CAS  Google Scholar 

  • Kaufman, S. and Friedman, S. (1965). Dopamine-β-hydroxylase. Pharmac. Rev., 17, 71–100

    CAS  Google Scholar 

  • Kirskey, D. F., Klein, R. L., Bagget J. McC. and Gasparis, M. S. (1978). Evidence that most of the dopamine-β-hydroxylase is not membrane bound in purified large dense cored noradrenergic vesicles. Neuroscience, 3, 71–81

    Article  Google Scholar 

  • Klein, R. L., Langerkrantz, H. and Zimmerman, H. (Eds.) (1982). Neurotransmitter Vesicles, Academic Press, London

    Google Scholar 

  • Langer, S. Z. (1981). Presynaptic regulation of the release of catecholamines. Pharmac. Rev., 32, 337–362

    Google Scholar 

  • Lokhandwala, M. F. and Barrett, R. J. (1982). Cardiovascular dopamine receptors: physiological, pharmacological and therapeutic implications. J. Autonom. Pharmac., 3, 189–215

    Article  Google Scholar 

  • Muller, B. D. and Bell, C. (1986). Vesicular storage of 3,4-dihydroxyphenylethyl-amine and noradrenaline in terminal sympathetic nerves of dog spleen and kidney. J. Neurochem., 47, 1370–1375

    Article  PubMed  CAS  Google Scholar 

  • Neumann, B., Wiedermann, C. J., Fisher-Colbrie, R., Schober, M., Sperk, G. and Winkler, H. (1984). Biochemical and functional properties of large and small dense-core vesicles in sympathetic nerves of rat and ox vas deferens. Neuroscience, 13, 921–931

    Article  Google Scholar 

  • Racz, K., Kuchel, O., Buu, N. T. and Tenneson, S. (1986). Peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats. Circulation Res., 58, 889–897

    Google Scholar 

  • Sarmento, A., Soares-da-Silva, P., Teixeira, A. A. and Azevedo, I. (1987). Effects of denervation induced by 6-hydroxydopamine on cell nucleus activity of arterial and cardiac cells of the dog. J. Autonom. Pharmac. (in press)

    Google Scholar 

  • Schömig, A., Dart, A. M., Dietz, R., Mayer, E. and Kubler, W. (1984). Release of catecholamines in the ischaemic myocardium of the rat. Part A: Locally mediated release. Circulation Res., 55, 689–701

    Article  PubMed  Google Scholar 

  • Soares-da-Silva, P. (1986). Evidence for a non-precursor dopamine pool in noradrenergic neurons of the dog mesenteric artery. Naunyn-Schmiedebergs Arch. Pharmac., 333, 219–223

    Article  CAS  Google Scholar 

  • Soares-da-Silva, P. (1987a). A comparison between the pattern of dopamine and noradrenaline release from sympathetic neurones of the dog mesenteric artery. Br. J. Pharmac., 90, 91–98

    Article  CAS  Google Scholar 

  • Soares-da-Silva, P. (1987b). Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels. Br. J. Pharmac., 91, 591–599

    Article  CAS  Google Scholar 

  • Soares-da-Silva, P. (1987c). Dopamine and noradrenergic transmission. In Van-houtte, P. M. (Ed.), Mechanisms of Vasodilatation, Raven Press, New York (in press)

    Google Scholar 

  • Soares-da-Silva, P. and Davidson, R. (1985). Effects of 6-hydroxydopamine on dopamine and noradrenaline content in dog blood vessels and heart. Evidence for a noradrenaline-independent dopamine pool. Naunyn-Schmiedebergs Arch. Pharmac., 329, 253–257

    Article  CAS  Google Scholar 

  • Sole, M. J., Kamble, A. B. and Hussain, M. N. (1977). A possible change in the rate-limiting step for cardiac norepinephrine synthesis in the cardiomyopatic Syrian Hamster. Circulation Res., 41, 814–817

    Article  PubMed  CAS  Google Scholar 

  • Sole, M. J., Helke, C. J. and Jakobowitz, D. M. (1982). Increased dopamine in the failing hamster heart: Transvesicular transport of dopamine limits the rate of norepinephrine synthesis. Am. J. Cardiol., 49, 1682–1690

    Article  PubMed  CAS  Google Scholar 

  • Starke, K. (1977). Regulation of noradrenaline release by presynaptic receptor systems. Rev. Physiol. Biochem. Pharmac., 77, 1–124

    CAS  Google Scholar 

  • Tarver, J. H., Berkowitz, B. A. and Spector, S. (1971). Alterations in tyrosine hydroxylase and monoamine oxidase activity in blood vessels. Nature New Biol., 231, 252–253

    Article  PubMed  CAS  Google Scholar 

  • Weiner, N. (1970). Regulation of norepinephrine biosynthesis. Ann. Rev. Pharmac., 10, 273–290

    Article  CAS  Google Scholar 

  • Willems, J. L., Buylaert, W. A., Lefebreve, R. A. and Bogaert, M. G. (1985). Neuronal dopamine receptors on autonomic ganglia and sympathetic nerves and dopamine receptors in the gastrointestinal system. Pharmac. Rev., 37, 165–215

    CAS  Google Scholar 

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Authors
  1. P. Soares-da-Silva
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Melbourne Medical Centre, Australia

    Christopher Bell

  2. Department of Medicine, Monash University Medical Centre, Australia

    Barry McGrath

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© 1988 P. Soares-da-Silva

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Soares-da-Silva, P. (1988). Dopamine Storage in Sympathetic Nerves. In: Bell, C., McGrath, B. (eds) Peripheral Actions of Dopamine. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-09503-2_2

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  • DOI: https://doi.org/10.1007/978-1-349-09503-2_2

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-09505-6

  • Online ISBN: 978-1-349-09503-2

  • eBook Packages: MedicineMedicine (R0)

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