Role of Selected Lobules of the Cerebellum in the Control of Locomotion
It is remarkable that classical studies on the cerebellum which were based solely on the “destruction” gross-lesion approach yielded such meaningful and still appropriate answers to the question “what does the cerebellum do”? For example, from observation of locomotor disturbances arising from cerebellar lesions, Flourens (1824) concluded that an animal with a damaged cerebellum could still initiate and execute a movement, but only in a clumsy manner. He concluded that this clumsiness arose from difficulties in coordinating the contraction of numerous muscles and the movements of various bodily parts. Similarly, Holmes classical (1922a,b) description of cerebellar “signs” in human patients has remained essentially unmodified and, indeed, his work is difficult to extend upon, despite much substantial effort and much technical progress in the field of clinical neurophysiology (for review: Brooks and Thach, 1982).
Unable to display preview. Download preview PDF.
- Brooks, V.B. and Thach, T. (1982). Cerebellar control of pustur.e and movement. In Handbook of’Physiology, Section I, Vol. II, The Nervous System. Motor Control, Part2. (ed. V.B. Brooks). Williams and Wilkins: Baltimore, MD, pp. 877–946.Google Scholar
- Dow, R.S. and Morüzzi, G. (1958). The Physiology and Pathology of the Cerebellum. University of Minnesota Press, Minneapolis.Google Scholar
- Flourens, P. (1824). Recherches experimentales sur les proprietes et les fonctions du systeme nerveux dans les animaux vertebres. Edition 1, Crevot, Paris.Google Scholar
- Holmes, G., (1922a,b). The clinical symptoms of cerebellar disease and their interpretation. Lancet I: 1177–1182, 1231–1237 and II: 59–65, 111–115.Google Scholar
- Ito, M. (1984). The Cerebellum and Neural Control. Raven Press, New York.Google Scholar
- Matsukawa, K. and Udo, M. (1985). Responses of cerebellar Purkinje cells to mechanical perturbations during locomotion of decerebrate cats. Neurosci. Res. 2, in press.Google Scholar
- Orlovsky, G.N., Severin, F.V. and Shik, M.L. (1966). Effect of damage to the cerebellum on the coordination of movement in the dog on running. Biophysics 11:578–588.Google Scholar
- Udo, M., Oda, Y., Tanaka, K. and Horikawa, J. (1976). Cerebellar control of locomotion investigated in cats: Discharges from Deiters neurones, EMG and limb movements during local cooling of the cerebellar cortex. In Progress in Brain Research, Vol. 44. (ed. S. Homma). Elsevier, Amsterdam, pp. 445–459.Google Scholar