Abstract
Nerve growth factor (NGF) is a well-defined protein which is necessary for the development and maintainance of differentiated properties of peripheral sympathetic and neural crest-derived sensory neurons (for review see Thoenen et al., 1985 and refs therein). Many morphological and biochemical effects of NGF have been described in both the physiological target cells of NGF and a clonal cell line (PC12) derived from a rat pheochromocytoma. NGF is known to bind to specific cell-surface receptors, an event which is followed by internalization of the ligand-receptor complex; however, the mechanism of signal transduction after NGF’s interaction with its receptor is unknown.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Acheson, A., Naujoks, K. and Thoenen, H. (1984) Nerve growth factor-mediated enzyme induction in primary cultures of bovine adrenal chromaffin cells: specificity and level of regulation. J. Neurosci. 4.: 1771–1780.
Acheson, A., Edgar, D., Timpl, R. and Thoenen, H. (1986a) Laminin increases both levels and activity of tyrosine hydroxylase in calf adrenal chromaffin cells. J. Cell Biol. 102: 151–159.
Acheson, A., Vogl, W., Huttner, W.B. and Thoenen, H. (1986b) Methyltransferase inhibitors block NGF-regulated survival and protein phosphorylation in sympathetic neurons. EMBO J. in press.
Aswad, D. (1984) Stoichiometric methylation of porcine adrenocoticotropin by protein carboxyl methyltransferase requires deamidation of asparagine 25. J. Biol. Chem. 259: 10714–10721.
Edgar, D., Timpl, R. and Thoenen, H. (1984) The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival. EMBO J. 3.: 1463–1468.
Clarke, S. (1985) Protein carboxyl methyltransferases: distinct classes of enzymes. Ann. Rev. Biochem. 54.: 479– 506.
Greenberg, M.E., Greene, L.A. and Ziff, E.B. (1985) Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J. Biol. Chem. 260: 14101–14110.
Greene, L.A., Seeley, P.J., Rukenstein, A., DiPiazza, M. and Howard, A. (1984) Rapid activation of tyrosine hydroxylase in response to nerve growth factor. J. Neurochem. 42: 1728–1734.
Johnson, B.A., Freitag, N.E. and Aswad, D.W. (1985) Protein carboxyl methyltransferase selectively modifies an atypical form of calmodulin. J. Biol. Chem. 260: 10913–10916.
Landreth, G.E. and Rieser, G.D. (1985) Nerve growth factor- and epidermal growth factor-stimulated phosphorylation of a PC12 cytoskeletally associated protein in situ. J. Cell Biol. 100; 677–683
Naujoks, K.W., Korsching, S., Rohrer, H. and Thoenen, H. (1982) Nerve growth factor-mediated induction of tyrosine hydroxylase and neurite outgrowth in cultures of bovine adrenal chromaffin cells: dependence on developmental stage. Dev. Biol. 92: 365–379.
O’Connor, C.M., Aswad, D.W. and Clarke, S. (1984) Mammalian brain and erythrocyte carboxyl methyltransferases are similar enzymes that recognize both D-aspartyl and L-isoaspartyl residues in structurally altered protein substrates. Proc. Natl. Acad. Sci. USA 81: 7757–7761.
Por, S.B. and Huttner, W.B. (1984) A Mr 70,000 phosphoprotein of sympathetic neurons regulated by nerve growth factor and by depolarization. J. Biol. Chem. 259: 6526–6533.
Schanche, J.-S., Schanche, T., Ueland, P.M., Holy, A. and Votruba, I. (1984) The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosyl-homocysteine hydrolase in intact rat hepatocytes. Mol. Pharmacol. 26: 553–558.
Seeley, P.J., Rukenstein, A., Connolly, J.L. and Greene, L.A. (1984) Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line. J. Cell Biol. 98.: 417–426.
Thoenen, H., Korsching, S., Heumann, R. and Acheson, A. (1985) Nerve growth factor. In:Growth Factors in Biology and Medicine (CIBA Foundation Symposium 116), Pitman, London, pp. 113–128.
Wakade, A.R. and Thoenen, H. (1984) Interchangeability of nerve growth factor and high potassium in the long-term survival of chick sympathetic neurons in serum-free culture medium. Neurosci. Lett. 45: 71–74.
Wakade, A.R., Edgar, D. and Thoenen, H. (1983) Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons. Exp. Cell Res. 144: 377–384.
Editor information
Editors and Affiliations
Copyright information
© 1987 The Wenner-Gren Center
About this chapter
Cite this chapter
Acheson, A., Thoenen, H. (1987). Potentiation of NGF-mediated Effects of Laminin. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08949-9_5
Download citation
DOI: https://doi.org/10.1007/978-1-349-08949-9_5
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-08951-2
Online ISBN: 978-1-349-08949-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)