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Gold in the treatment of rheumatoid arthritis

  • R. C. Butler
Chapter

Abstract

Published trials of gold treatment in rheumatoid arthritis have been reviewed. There is clear evidence that a six-month course of gold injections will reduce symptoms and signs of synovitis and improve patient well-being to a greater extent than placebo. This advantage will persist for one year after injections have been stopped, but can no longer be demonstrated after a further year. There is no compelling evidence that treatment for longer than six months is of value. Evidence that gold alters the outcome in rheumatoid arthritis is scanty, and the contention that gold retards radiological deterioration rests largely on a single prospective study in 27 patients. The undoubted short-term and equivocal longer-term benefits of gold therapy are achieved at a high price in terms of toxicity; even when long-term treatment is attempted, only a minority of patients will remain on treatment after three years. The place of gold salts in the treatment of rheumatoid arthritis needs to be reassessed.

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© D. H. Goddard and R. C. Butler 1984

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  • R. C. Butler

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