Transplantation of 5-HT Neurons to the Adult Rat Brain
Transplantation of monoaminergic neurons has raised considerable interest since the advent of specific histochemical techniques which have permitted first, a precise anatomical mapping of noradrenergic, dopaminergic and serotonergic neurons and, second, an evaluation of their ability to regenerate, once severed, and to invade the host’s tissue once transplanted (Gash, 1983). The usefulness of this new anatomical approach was exemplified by its showing that Parkinson’s disease is the result of the lesion of dopaminergic neurons of the substantia nigra, leading itself to the depletion of striatal dopamine. It was soon found that drug treatment was able to partially reverse neurological symptoms, and one could anticipate that cell replacement could do as least as well as drug therapy, thus providing a rationale for neural transplants in the mammalian brain (Freed et al., 1984).
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