Abstract
Transplantation of monoaminergic neurons has raised considerable interest since the advent of specific histochemical techniques which have permitted first, a precise anatomical mapping of noradrenergic, dopaminergic and serotonergic neurons and, second, an evaluation of their ability to regenerate, once severed, and to invade the host’s tissue once transplanted (Gash, 1983). The usefulness of this new anatomical approach was exemplified by its showing that Parkinson’s disease is the result of the lesion of dopaminergic neurons of the substantia nigra, leading itself to the depletion of striatal dopamine. It was soon found that drug treatment was able to partially reverse neurological symptoms, and one could anticipate that cell replacement could do as least as well as drug therapy, thus providing a rationale for neural transplants in the mammalian brain (Freed et al., 1984).
Preview
Unable to display preview. Download preview PDF.
References
Anden, N. E., Dahlström, A., Fuxe, K., Larsson, K., Olsen, L., and Ungerstedt, U. (1966). Ascending monoamine neurons to the telencephalon and diencephalon. Acta Physiol. Scand., 67, 313–26.
Azmitia, E. C., Perlow, M. J., Brennan, M. J., and Lauder, J. M. (1981). Fetal raphe and hippocampal transplants into adult and aged C57BL/6N mice: a preliminary immuno-cytochemical study. Brain Res. Bull., 7, 703–10.
Bowen, D. M., Davison, A. M., Francis, P. T., Palmer, A. M., and Pearce, B. R. (1985). Neurotransmitter and metabolic dysfunction in Alzleimer’s dementia: relationship to histopathological features. Interdiscipl. Topics Geront., 19, 156–74.
Bowen, D. M., Allen, S. J., Benton, J. S., Goodhardt, M. J., Haan, E. A., Palemr, A. M., Sims, N. R., Smith, C. C. T., Spillane, J. A., Esiri, M. M., Neary, D., Snowdon, J. S., Wilcock, G. K., and Davison, A. N. (1983). Biochemical assessment of serotoninergic and cholinergic dysfunction and cerebral atrophy in Alzheimer’s disease. J. Neurochem., 41, 266–72.
Commissiong, J. W. (1984). Fetal locus coeruleus transplanted into the transected spinal cord of the adult rat: some observation and implications. Neurosci., 21, 839–53.
Consolazione, A., and Cuello, A. C. (1982). CNS serotonin pathways. In Osborne, N. N. (ed.), Biology of Serotonergic Transmission. Wiley, Chichester, 29–61.
Descarries, L., Beaudet, A., and Watkins, K. C. (1975). Serotonin nerve terminals in adult rat neocortex. Brain Res., 100, 563–88.
Freed, W. J., Hoffer, B. J., Olsen, L., and Wyatt, R. J. (1984). Transplantation of catecholamine-containing tissues to restore the functional capacity of damaged nigrostriatal system. In Sladek, J. R., and Gash, D. M. (eds.), Neural Transplants: Development and Function. Plenum Press, New York, pp. 373–402.
Freund, T. F., Bolam, J. P., Bjordklund, A., Stenevi, U., Dunnet, S. B., Powel, J. F., and Smith, A. D. (1985). Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosin hydroxylase immunocytochemical study. J. Neurosci., 5, 603–16.
Gash, D. M. (1983). Neural transplants in mammals. A historical overview. In: Sladek, J. R., and Gash, D. M. (eds.), Neural Transplants: Development and Function. Plenum Press, New York, 1–11.
Geffard, M., Henrich-Roch, A-M., Dulluc, J., and Seguela, P. H. (1985). Antisera against small neurotransmitter-like molecules. Neurochem. Int., 7, 403–13.
Jaeger, C. B. (1985). Cytoarchitectonies of substantia nigra grafts: a light and electron microscopic study of immunocytochemically identified dopaminergic neurons and fibrous astrocytes. J. Comp. Neurol., 231, 121–35.
Lauder, J. M., Wallace, J. A., Krebs, H., Peterusz, P., and McCarthy, K. (1982). In vivo and in vitro development of serotonergic neurons. Brain Res. Bulletin, 9, 605–25.
Lerner-Natoli, M., Rondouin, G., Malafosse, A., Sandillon, F., and Privat, A. (1986). Facilitation of olfactory bulb kindling after specific destruction of serotoninergic terminals in the olfactory bulb of rat. Neurosci. Lett., 66, 299–304.
McRae-Degueurce, A., Didier, M., and Pujol, J. F. (1981). The viability of transplants of mesencephalic raphe nuclei in the 15th ventricle of adult rat. Neurosci. Lett., 24, 251–4.
McRae-Degueurce, A., Lauder, J. M., and Privat, A. (1983). Adult age destruction versus neonatal age destruction of the serotonin system: two models to investigate the survival of serotonin neurons transplanted in adult rats. Neurosci. Lett., 40, 27–32.
McRae Degueurce, A., Serrano, A., Sandilion, F., Privat, A., and Scatton, B. (1984). In vivo voltametric measurement of extra-cellular 5-HIAA in the denervated striatum after transplantation of mesencephalic raphe neurons. Neurosci. Lett., 48, 97–102.
Mahalik, T. J., Finger, T. E., Stromberg, I., and Olson, L. (1985). Substantia nigra transplants into denervated striatum of the rat: ultrastructure of graft and host interconnections. J. Comp. Neurol., 240, 60–70.
Nornes, H., Bjorklund, A., and Stenevi, U. (1984). Transplantation strategies in spinal cord regeneration. In Sladek, J. R., and Gash, D. M. (eds.), Neural Transplants: Development and Function. Plenum Press, New York, 407–21.
Nygren, L. G., Olson, L., and Seiger, A. (1977). Monoaminergic reinnervation of transected spinal cord by homologous fetal brain grafts. Brain Res., 129, 227–35.
Privat, A. (1982). In vitro cultures of serotonergic neurons from fetal rat brain. J. Histochem. Cytochem., 30, 185–7.
Privat, A., Mansour, H., Pavy, A., Geffard, M., and Sandillon, F. (1985). Transplantation of foetal 5-HT neurons into the transected spinal cord of adult rats. Neurosci. Lett., 66, 61–6.
Racine, R. J., and Coscina, D. V. (1979). Effects of midbrain raphe lesions or systemic p-chlorophenylalaline on the development of kindles seizures in rats. Brain Res. Bull., 4, 1–7.
Steinbusch, H. W. M. (1984). Serotonin-immunoreactive neurons and their projections in the CNS. In Bjorklund, A., Hökfelt, T., and Kuhar, M. J. (eds.), Handbook of Chemical Neuroanatomy. Elsevier, Amsterdam, pp. 68–125.
Steinbusch, H. W. M., Verhofstad, A. J., and Joosten, H. W. J. (1978). Localization of serotonin in the central nervous system by immunohistochemistry: desctruction of a specific and sensitive technique and some applications. Neurosci., 3, 811–19.
Editor information
Editors and Affiliations
Copyright information
© 1986 The Editors and the Contributors
About this chapter
Cite this chapter
Privat, A., Mansour, H., Geffard, M., Lerner-Natoli, M. (1986). Transplantation of 5-HT Neurons to the Adult Rat Brain. In: Briley, M., Kato, A., Weber, M. (eds) New Concepts in Alzheimer’s Disease. Palgrave, London. https://doi.org/10.1007/978-1-349-08639-9_21
Download citation
DOI: https://doi.org/10.1007/978-1-349-08639-9_21
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-08641-2
Online ISBN: 978-1-349-08639-9
eBook Packages: MedicineMedicine (R0)