Abstract
The identification, purification and study of the mode of action of macro-molecular factors responsible for the survival, neurite outgrowth and differentiation of neurons in culture is nowadays a field of intense research (for a review, see Berg, 1985). Cell culture systems can indeed constitute valuable biological assays for the identification of neuronotrophic factors in various biological fluids or tissue homogenates. Except for nerve growth factor (NGF), the role played by these factors during in vivo development or ageing is still unknown, but they are good candidates for the mediation of retrograde trophic interactions between defined groups of neurons and their field of innervation. A defect in such retrograde factors may be involved in certain degenerative neurological diseases, such as motor neuron disease or Alzheimer’s disease (see Chapters 13, 14 and 16).
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Giess, M.C. et al. (1986). A Glycoprotein from Muscle-conditioned Medium Involved in the Differentiation of Rat Cholinergic Neurons in Culture: Partial Purification and Regulation of Neurotransmitter Metabolism Enzymes in Central-Nervous-System Cultures. In: Briley, M., Kato, A., Weber, M. (eds) New Concepts in Alzheimer’s Disease. Palgrave, London. https://doi.org/10.1007/978-1-349-08639-9_15
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DOI: https://doi.org/10.1007/978-1-349-08639-9_15
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