An Immunohistochemical Study Comparing Selected Features of the Anatomy of Cholinergic Innervation in the Cerebral Cortex of Six Mammalian Species
Many different investigators have contributed over the last five decades to establishing acetylcholine (ACh) as a neurotransmitter in cerebral cortex. Besides ACh itself, all biochemical correlates of cholinergic function, such as the ACh synthesising and degrading enzymes, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE), respectively, as well as ACh receptors and the high affinity uptake mechanism have all been shown to be present in cortex. In addition, cortical neurons have been found to be sensitive to extracellular application of ACh (for reviews see Emson and Lindvall, 1979; Parnavelas and McDonald, 1983; Eckenstein and Baughman, 1986).
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