Anatomical Organization of NMDA, Kainate and Quisqualate Receptors
The anatomical localization of excitatory amino acid receptors is necessary for evaluating their functional role in specific pathways and systems in the CNS. Autoradiography allows a quantitative description of anatomical and pharmacological properties of binding sites in specific CNS locations which can then be correlated to function. Receptors in a single dendritic field can be both biochemically characterized and rigorously studied by electrophysiological techniques. It is also possible, once the sites are defined, to study their development, the effects of lesions, and the consequences of treatments upon receptors in discrete pathways.
KeywordsNMDA Tritium Octanoate Hexanoate Heptanoate
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