Abstract
Within recent years, considerable attention has been paid to the role of postsynaptic receptors for excitatory amino acids within the mammalian central nervous system, and this has led to the characterisation of at least three subtypes (viz. those activated by N-methyl-Daspartate (NMDA), quisqualate and kainate) on the basis of electrophysiological studies (see Watkins, this volume). In contrast to the postsynaptic receptors, relatively little attention has been paid to either the existence (although of course their possible presence might contribute substantially to the binding seen on synaptic plasma membranes) or characteristics of presynaptic receptors for excitatory amino acids.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Collins, G.G.S., Anson, J. and Surtees, L. (1983). Presynaptic kainate and N-methyl-Daspartate receptors regulate excitatory amino acid release in the olfactory cortex. Brain Res., 265, 157–159.
Evans, R.H. and Watkins, J.C. (1981). Pharmacological antagonists of excitatory amino acids. Life Sci., 28, 1303–1308.
Ferkany, J.W., Zaczek, R. and Coyle, J.T. (1982). Kainic acid stimulates excitatory amino acid transmitter release at presynaptic receptors. Nature, 298, 757–759.
Giorguieff, M.F., Kemel, M.L. and Glowinski, J. (1977). Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci. Lett. 6, 73–77.
Godukhin, O.V., Zharikova, A.D. and Budantsev, A. Yu. (1984). Role of presynaptic dopamine receptors in regulation of the glutamatergic neurotransmission in rat neostriatum. Neuroscience, 12, 377–383.
Graham, L.T. Jr., and Aprison, M.H. (1966). Fluorimetric determination of aspartate, glutamate and GABA in nerve tisues using enzymatic methods. Analyt. Biochem., 15, 487–497.
Johnston, G.A.R. (1981). Glutamate uptake and its possible role in neurotransmitter inactivation. In Glutamate; Transmitter in the Central Nervous System, (eds. P.J. Roberts, J. Storm-Mathisen and G.A.R. Johnston). Wiley, Chichester.
Kalsner, S. (1985). Is there feedback regulation of neurotransmitter release by autoreceptors. Biochem. Pharmacol., 34, 4085–4097.
Krogsgaard-Larsen, P., Honore, T., Hansen, J.J., Curtis, D.R. and Lodge, D. (1 980). New class of glutamate agonists structurally related to ibotenic acid. Nature, 284, 64–66.
Laduron, P.M. (1985). Presynaptic heteroreceptors in regulation of neuronal transmission. Biochem. Pharmacol., 34, 467–470.
Lehmann, J. and Scatton, B. (1982). Characterisation of the excitatory amino acid-receptor mediated release of [3H]acetylcholine from rat striatal slices. Brain Res., 252, 77–89.
Marien, M., Brien, J. and Jhamandas, K. (1983). Regional release of [3H]dopamine from rat brain in vitro: effects of opioids on release induced by potassium, nicotine and L-glutamic acid. Can. J. Physiol. Pharmacol., 61, 43–60.
McBean, G.J. and Roberts, P.J. (1981). Glutamate preferring receptors regulate release of Daspartate from rat hippocampal slices. Nature, 291, 593–594.
Recasens, M., Saadoun, F., Maitre, M., Baudry, M., Lynch, G., Mandel, P. and Vincendon, G. (1983). Cysteine sulphinate receptors in rat CNS. In CNS Receptors — From Molecular Pharmacology to Behaviour (eds. P. Mandel and F.V. DeFeudis), Raven Press, New York.
Roberts, P.J. and Anderson, S.D. (1979). Stimulatory effect of L-glutamate and related amino acids on [3H] dopamine release from rat striatum: an in vitro model for glutamate actions. J. Neurochem., 32, 1539–1545.
Roberts, P.J., McBean, G.J., Sharif, N.A. and Thomas, E.M. (1982). Striatal glutamatergic function: modifications following specific lesions. Brain Res., 235, 83–91.
Schwartzkroin, P.A. (1975). Characteristics of CA1 neurones recorded intracellularly in the hippocampal in vitro slice preparation. Brain Res., 85, 423–426.
Segal, M. (1981). The actions of glutamic acid on neurones in the rat hippocampal slice. In Glutamate as a Neurotransmitter. (eds. G. Di Chiara and G.L. Gessa). Raven Press, New York.
Skerritt, J.H., Johnston, G.A.R. and Willow, M. (1981). Amino acid release from rat brain slices: evidence for autoreceptors for GABA but not for Daspartate. Proc. Aus. Physiol. Pharmacol. Soc, 12, 131 P.
Starke, K. (1979). Presynaptic regulation of release in the central nervous system. In The Release of catecholamines from Adrenergic Neurones (ed. D.M. Paton) Pergamon Press, Oxford. pp 143–183.
Storm-Mathisen, J. and Wold, J.E. (1981). In vivo uptake and axonal transport of Daspartate in excitatory neurones. Brain Res., 230, 427–433.
Editor information
Editors and Affiliations
Copyright information
© 1986 The Editors and the Contributors
About this chapter
Cite this chapter
Roberts, P.J. (1986). Presynaptic Receptors for Excitatory Amino Acid Transmitters. In: Roberts, P.J., Storm-Mathisen, J., Bradford, H.F. (eds) Excitatory Amino Acids. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08479-1_13
Download citation
DOI: https://doi.org/10.1007/978-1-349-08479-1_13
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-08481-4
Online ISBN: 978-1-349-08479-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)