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Hepatitis B Virus and Primary Cancer of the Liver

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Vaccine Intervention Against Virus-Induced Tumours
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Abstract

In this introductory chapter the use of vaccines to intervene against virus-induced tumours will be discussed, the hepatitis B virus (HBV) and its causative role in primary hepatocellular carcinoma (PHC) being used as an example.

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References

  1. London WT, Blumberg BS (1983) Hepatitis B and related viruses in chronic hepatitis, cirrhosis and hepatocellular carcinoma in man and animals. In: Cohen S, Soloway RD (eds) Chronic active liver disease. Churchill Livingstone, New York, p 147–170

    Google Scholar 

  2. Blumberg BS, London WT (1985) Guest Editorial. Hepatitis B virus and the prevention of primary cancer of the liver. Journal of the National Cancer Institute 74: 267–273

    PubMed  CAS  Google Scholar 

  3. Blumberg BS, Larouze B, London WT, Werner B, Hesser JE, Millman I, Saimot G, Payet M (1975) The relation of infection with the hepatitis B agent to primary hepatic carcinoma. American Journal of Pathology 81: 669–682

    PubMed  CAS  PubMed Central  Google Scholar 

  4. Nishioka K, Hirayama T, Sekine T, Okochi K, Mayumi M, Sung J-L, Liu C-H, Lin T-M (1973) Australia antigen and hepatocellular carcinoma. GANN Monograph on Cancer Research 14: 167–175

    Google Scholar 

  5. Blumberg BS, Millman I (1972) Patent Vaccine against viral hepatitis and process. Submitted October 8, 1969. US Patent Office No 3,636, 191, 1972

    Google Scholar 

  6. Szmuness W, Stevens CE, Harley EJ, Zang EA, Oleszko WR, William DC, Sadovsky R, Morrison JM, Kellner A (1980) Hepatitis B vaccine: Demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. New England Journal of Medicine 303: 833–841

    Article  PubMed  CAS  Google Scholar 

  7. Kessler H, Chase R, Harris A, Jensen D, Levin S (1985) HTLV-III antibodies after hepatitis B vaccination. Lancet 1: 1506–1507

    Article  PubMed  CAS  Google Scholar 

  8. Poisz B, Tomar R, Lehr B, Moore J (1984) Hepatitis B vaccine: evidence confirming lack of AIDS transmission. Morbidity and Mortality Weekly Report 33: 685–687

    Google Scholar 

  9. Kirschbaum A, Salomon A, Parker E, Abarca V, Contreras L, Chomali M, Dinator R, Escobar L, Fabre V, Gelman M, Gutierrez V, Hazbun M, Murillo V, Opazo A, Riveros T, SammanM (1985) Recommendations for protection against viral hepatitis. Recommendation of the Immunization Practices Advisory Committee (ACIP). Morbidity and Mortality Weekly Report 34: 314–335

    Google Scholar 

  10. Beasley RP, Lin C-C, Hwang L-Y, Chien C-S (1981) Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22,707 men in Taiwan. Lancet 2: 1129–1133

    Article  PubMed  CAS  Google Scholar 

  11. Marinier E, Barrois V, Larouze B, London WT, Cofer A, Diakhate L, Blumberg BS (1985) Lack of perinatal transmission of hepatitis B virus infection in Senegal, West Africa. Journal of Pediatrics 106: 843–849

    Article  PubMed  CAS  Google Scholar 

  12. Urban MK, O’Connell AP, London WT (1985) Sequence of events in natural infection of Pekin duck embryos with duck hepatitis B virus. Journal of Virology 55: 16–22

    PubMed  CAS  PubMed Central  Google Scholar 

  13. Tang Z, Yang B, Tang C, Yu Y, Lin Z, Weng H (1980) Evaluation of population screening for hepatocellular carcinoma. Chinese Medical Journal 93: 795–799

    PubMed  CAS  Google Scholar 

  14. Drew JS, London WT, Lustbader ED, Hesser JE, Blumberg BS (1978) Hepatitis B virus and sex ratio of offspring. Science 201: 687–692

    Article  PubMed  CAS  Google Scholar 

  15. Drew J, London WT, Blumberg BS, Serjeantson S (1982) Hepatitis B virus and sex ratio on Kar Kar Island. Human Biology 54: 123–135

    PubMed  CAS  Google Scholar 

  16. London WT, Stevens RG, Shofer FS, Drew JS, Brunhofer JE, Blumberg BS (1982) Effects of hepatitis B virus on the mortality, fertility and sex ratio of human populations. In: Szmuness W, Alter HJ, Maynard JE (eds) Viral hepatitis. Franklin Institute Press, Philadelphia, p 195–202

    Google Scholar 

  17. Drew JS, Blumberg BS, Robert-Lamblin J (1986) Hepatitis B virus and sex ratio of offspring in East Greenland. Human Biology 58: 115–120

    PubMed  CAS  Google Scholar 

  18. London WT, Drew JS (1977) Sex differences in response to hepatitis B infection among patients receiving chronic dialysis treatment. Proceedings of the National Academy of Sciences USA 74: 2561–2563

    Article  CAS  Google Scholar 

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© 1986 The Leukaemia Research Fund

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Blumberg, B.S. (1986). Hepatitis B Virus and Primary Cancer of the Liver. In: Goldman, J.M., Epstein, M.A. (eds) Vaccine Intervention Against Virus-Induced Tumours. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08243-8_1

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  • DOI: https://doi.org/10.1007/978-1-349-08243-8_1

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-08245-2

  • Online ISBN: 978-1-349-08243-8

  • eBook Packages: MedicineMedicine (R0)

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