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Studies of Local Blood Flow and Glucose Utilization in Brain by Computer Assisted Autoradiography

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Quantitative Neuroanatomy in Transmitter Research

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

It has for a long time been assumed that the cerebrovascular bed differs fundamentally from the peripheral circulation in that perivascular nerves are lacking and that the control of flow in the brain is exerted entirely by “chemical” or “metabolic” mediators. With the application of highly sensitive and specific neurohistochemical methods for visualization of amin- ergic transmitters (Falck, 1962; Falck et al., 1962; Björklund et al., 1972) and, later on, for the demonstration of various neuropeptides (Hökfelt et al., 1980) it has now been established that the cerebrovascular bed is, indeed, extensively supplied with several systems of perivascular nerve fibres (Owman et al., 1984). This has led to the additional concept of “neurogenic” control mechanisms for the brain circulation (Owman and Edvins- son, 1977; Heistad and Marcus, 1982; MacKenzie et al., 1984).

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Author information

Authors and Affiliations

  1. Department of Histology, University of Lund, Sweden

    Christer Owman

  2. Department of Neuropathology, University of Copenhagen, Denmark

    Nils H. Diemer

Authors
  1. Christer Owman
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  2. Nils H. Diemer
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Editor information

Editors and Affiliations

  1. Department of Human Physiology, University of Modena, Modena, Italy

    Luigi F. Agnati

  2. Department of Histology, Karolinska Institutet, Stockholm, Sweden

    Kjell Fuxe

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© 1985 The Wenner-Gren Centre

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Owman, C., Diemer, N.H. (1985). Studies of Local Blood Flow and Glucose Utilization in Brain by Computer Assisted Autoradiography. In: Agnati, L.F., Fuxe, K. (eds) Quantitative Neuroanatomy in Transmitter Research. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08171-4_6

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