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The Use of Quantitative Immunocyto-Chemistry to Study the Regulation of Tyrosine Hydroxylase in Noradrenergic and Dopaminergic Neural Systems

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Quantitative Neuroanatomy in Transmitter Research

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

Immunocytochemistry has now established itself as one of the most powerful techniques available for understanding the neurobiology of neuron- specific macromolecules in the brain. Using antibodies directed either against neurotransmitters, (Choy and Watkins, 1977; Steinbusch et al. 1978; Sternberger, 1979), the enzymes required for their biosynthesis (Pickel et al. 1975a, b; Sternberger, 1979), or even receptor associated molecules, (Strader, et. al. 1983) the distribution and biochemical anatomy of specific transmitter classes and their relationship to identifiable neuronal populations has been established.

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Benno, R.H., Tucker, L.W., Joh, T.H., Reis, D.J. (1985). The Use of Quantitative Immunocyto-Chemistry to Study the Regulation of Tyrosine Hydroxylase in Noradrenergic and Dopaminergic Neural Systems. In: Agnati, L.F., Fuxe, K. (eds) Quantitative Neuroanatomy in Transmitter Research. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08171-4_18

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