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Ganglion Blockers

  • Chapter
Mechanisms of Drug Action

Abstract

The term ‘ganglion blocking agents’ is commonly used for the chemical compounds that block synaptic transmission through the autonomic ganglia selectively — i.e. at doses lower than those needed to block transmission through other synapses. Briefly, the transmission is a sequence of processes that starts with the release of synaptic transmitter, acetylcholine (ACh), from the terminals of preganglionic fibres. The released ACh interacts with nicotinic acetylcholine receptors, the protein molecules incorporated into the postsynaptic membrane of the ganglion neurons. It is thought that each acetylcholine receptor consists of two functionally different parts: the recognition component that binds ACh, and the ion channel. The interaction of ACh with recognition component is followed by a transient opening of the ion channel. The excitatory postsynaptic current (EPSC) which flows through many ACh receptor channels produces across the excitable membrane of the neuron the excitatory postsynaptic potential (EPSP) that triggers postsynaptic spike.

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  1. A. A. Bogomoletz Institute of Physiology, Kiev-24, Ukraine

    V. I. Skok

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  1. Merck Sharp & Dohme Research Laboratories, Neurosciences Research Centre, Essex CM20 2QR, Harlow, UK

    G. N. Woodruff

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Skok, V.I. (1986). Ganglion Blockers. In: Woodruff, G.N. (eds) Mechanisms of Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08026-7_3

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