Reverse Mutation in Salmonella typhimurium

  • R. Forster
  • R. D. Gwilliam

Abstract

This laboratory participated in the Second UKEMS Collaborative Study, contributing to the work of the bacterial group. Our task was to test DAB and its analogue CDA, with both uninduced rat liver S9 and chicken liver S9. The test chemicals, S9 and bacterial cultures were provided by the study organisers, and we employed standard methods and experimental design as required. The results that we obtained are described below.

Keywords

DMSO MgCl2 Toxicology NADP Norharman 

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Notes

  1. Ames, B.N., McCann, J. and Yamasaki, E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/ mammalian-microsome test. Mutation Res. 31: 347–364PubMedCrossRefGoogle Scholar
  2. de Serres, F.J. and Ashby, J. (eds.) (1981). Evaluation of Short-term Tests for Carcinogens (Progress in Mutation Research Ser. Vol.1). Elsevier/ North HollandGoogle Scholar
  3. Lefevre, P.A. and Ashby, J. (1981). The effects of preincubation period and norharman on the mutagenic potency of 4-dimethylaminoazobenzene and 3-methyl-4-dimethylaminoazobenzene in S. typhimurium. Carcinogenesis 2: 927–931PubMedCrossRefGoogle Scholar

Copyright information

© United Kingdom Environmental Mutagen Society 1985

Authors and Affiliations

  • R. Forster
    • 1
  • R. D. Gwilliam
    • 2
  1. 1.LSR Roma Toxicology CentrePomeziaItaly
  2. 2.Water Research CentreMedmenham LaboratoryMedmenham, MarlowUK

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