An Evaluation of the Genotoxicity of BZD, DAT, DAB and CDA in the Sex-linked Recessive Lethal Test Using Drosophila melanogaster
BZD, DAT, DAB and two samples of CDA (A and B) were assayed for their abilities to induce sex-linked recessive lethal mutations in the fruit fly Drosophila melanogaster using the technique of adult feeding.
BZD at concentrations of up to 2000 µg/ml was negative in the assay whereas its structural analogue DAT gave a positive response at concentrations of 500 and 1000 µg/ml. DAB and Sample A of CDA gave positive results at 1000 and 2000 µg/ml and 200 and 1000 µg/ml respectively, whereas Sample B of CDA showed no genetic activity when tested at 1000 µg/ml.
KeywordsToxicity Foam DMSO Benzidine
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