An Evaluation of the Genotoxicity of BZD, DAT, DAB and CDA in the Sex-linked Recessive Lethal Test Using Drosophila melanogaster
BZD, DAT, DAB and two samples of CDA (A and B) were assayed for their abilities to induce sex-linked recessive lethal mutations in the fruit fly Drosophila melanogaster using the technique of adult feeding.
BZD at concentrations of up to 2000 µg/ml was negative in the assay whereas its structural analogue DAT gave a positive response at concentrations of 500 and 1000 µg/ml. DAB and Sample A of CDA gave positive results at 1000 and 2000 µg/ml and 200 and 1000 µg/ml respectively, whereas Sample B of CDA showed no genetic activity when tested at 1000 µg/ml.
KeywordsTest Compound Wild Type Male Adult Feeding Mutagenic Impurity Single Mutational Event
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- Mitchell, I. de G. and Combes, R.D. (1984). Mutation tests with the fruit fly Drosophila melanogaster. In Mutagenicity Testing — a Practical Approach by S. Venitt and J.M. Parry. IRL Press, OxfordGoogle Scholar
- Vogel, E. and Sobels, F.K. (1976). In Chemical Mutagens: Principals and Methods for their Detection, Vol.4, (ed. A. Hollaender). Plenum Press, New YorkGoogle Scholar