An Evaluation of the Genotoxicity of BZD, DAT, DAB and CDA in the Sex-linked Recessive Lethal Test Using Drosophila melanogaster

  • James M. Parry
  • P. B. Sinclair

Abstract

BZD, DAT, DAB and two samples of CDA (A and B) were assayed for their abilities to induce sex-linked recessive lethal mutations in the fruit fly Drosophila melanogaster using the technique of adult feeding.

BZD at concentrations of up to 2000 µg/ml was negative in the assay whereas its structural analogue DAT gave a positive response at concentrations of 500 and 1000 µg/ml. DAB and Sample A of CDA gave positive results at 1000 and 2000 µg/ml and 200 and 1000 µg/ml respectively, whereas Sample B of CDA showed no genetic activity when tested at 1000 µg/ml.

Keywords

Toxicity Foam DMSO Benzidine 

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Notes

  1. Kastenbaum, M.A. and Bowman, K.D. (1970). Tables for determining the statistical significance of mutation frequencies. Mutation Res. 9: 527–549PubMedCrossRefGoogle Scholar
  2. Mitchell, I. de G. and Combes, R.D. (1984). Mutation tests with the fruit fly Drosophila melanogaster. In Mutagenicity Testing — a Practical Approach by S. Venitt and J.M. Parry. IRL Press, OxfordGoogle Scholar
  3. Vogel, E. and Sobels, F.K. (1976). In Chemical Mutagens: Principals and Methods for their Detection, Vol.4, (ed. A. Hollaender). Plenum Press, New YorkGoogle Scholar

Copyright information

© United Kingdom Environmental Mutagen Society 1985

Authors and Affiliations

  • James M. Parry
    • 1
  • P. B. Sinclair
    • 2
  1. 1.Department of GeneticsUniversity College of SwanseaSwanseaUK
  2. 2.Microtest Research LtdUniversity RoadHeslingtonUK

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