Effects of Two Carcinogens and Two Structural Analogues on the Frequencies of Chromosome Aberrations, Polyploidy and Sister Chromatid Exchanges in vitro
The four compounds were tested in cultures of rat liver (RL4) cells for their ability to induce structural chromosome aberrations, polyploidy and sister chromatid exchanges (SCE). DAT, DAB and Sample B of CDA did not induce an increase in the frequency of chromosome aberrations or SCE. None of the compounds increased the level of polyploidy. Benzidine induced an unequivocal dose-related increase in chromosome aberrations and a statistically significant increase in SCE. From these results benzidine would be classified as geno-toxic.
KeywordsChromosome Aberration Sister Chromatid Exchange Cloning Efficiency Structural Aberration Sister Chromatid Exchange Frequency
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