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Comparative Genetic Toxicology pp 307–310Cite as

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The Mutagenic Effects of DAB and CDA in a Thymidine Kinase-deficient Clone of Friend Mouse Leukaemia Cells

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Abstract

Clone 707 of the Friend mouse leukaemia cell line (Scher et al., 1971) has been shown to have a high spontaneous mutation rate at the thymidine kinase locus (McKenna and Hickey, 1981a). Deficiency of thymidine kinase in subclones of 707 has been observed to result in increased sensitivity to killing and mutagenesis by UV irradiation (McKenna and Hickey, 1981b) and by chemical mutagens (McKenna and Yasseen, 1982). The present communication describes the mutagenic effects of 4-dimethylaminoazobenzene (DAB) and Sample B of 4-cyano-dimethylaniline (CDA) in the thymidine kinase-deficient Friend cell clone, 7O7BUF. The marker used for measurements of mutant induction was 6-thioguanine (6-TG) resistance.

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Notes

  • Scher, W., Holland, J.G. and Friend, C. (1971). Hemoglobin synthesis in murine virus-induced leukemic cells in vitro. Blood 37: 428–437

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  • McKenna, P.G. and Hickey, I. (1981a). The thymidine kinase locus of Friend erythroleukaemic cells. 1. Mutation rates and properties of mutants. Mutation Res. 80: 187–199

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  • McKenna, P.G. and Hickey, I. (1981b). UV-sensitivity in thymidine kinase deficient mouse erythroleukaemia cells. Cell Biol. Int. Reps. 5: 555–561

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  • McKenna, P.G. and Yasseen, A.A. (1982). Increased sensitivity to cell killing and mutagenesis by chemical mutagens in thymidine-kinase-deficient subclones of a Friend murine leukaemia cell line. Genet. Res. 40: 207–212

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Author information

Authors and Affiliations

  1. Department of Biology, The University of Ulster, Coleraine, Northern Ireland, BT52 1SA

    P. G. McKenna

Authors
  1. P. G. McKenna
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Editor information

Editors and Affiliations

  1. Department of Genetics, University College Swansea, UK

    J. M. Parry

  2. MRC Cell Mutation Unit, University of Sussex, UK

    C. F. Arlett

Copyright information

© 1985 United Kingdom Environmental Mutagen Society

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McKenna, P.G. (1985). The Mutagenic Effects of DAB and CDA in a Thymidine Kinase-deficient Clone of Friend Mouse Leukaemia Cells. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_36

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