Gene Mutation in Yeast Induced by DAB, CDA, BZD and DAT
DAB, CDA, BZD and DAT were tested for the induction of gene mutation in Saccharomyces cerevisiae strain XV185–14C 3. All these agents showed weak mutagenicity when tested in the presence of microsomes after the tester strain had been pretreated with nystatin to increase permeability. However, in the absence of microsomes or nystatin pretreatment, there was very little, or no, genetic activity at any of the loci under test.
KeywordsYeast Nitrogen Base Cytochrome P450 Activity Forward Mutation Microsomal Activation Microbial Assay
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