Gene Mutation in Yeast Induced by DAB, CDA, BZD and DAT

  • I. G. de Mitchell
  • P. J. Gilbert


DAB, CDA, BZD and DAT were tested for the induction of gene mutation in Saccharomyces cerevisiae strain XV185–14C 3. All these agents showed weak mutagenicity when tested in the presence of microsomes after the tester strain had been pretreated with nystatin to increase permeability. However, in the absence of microsomes or nystatin pretreatment, there was very little, or no, genetic activity at any of the loci under test.


Yeast Nitrogen Base Cytochrome P450 Activity Forward Mutation Microsomal Activation Microbial Assay 
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Copyright information

© United Kingdom Environmental Mutagen Society 1985

Authors and Affiliations

  • I. G. de Mitchell
    • 1
  • P. J. Gilbert
    • 1
  1. 1.Beecham Pharmaceuticals Research DivisionStockUK

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