Summary
BZD and DAT were tested for their ability to induce mitotic gene conversion in yeast strain D7 using a variety of experimental protocols utilising exogenous Aroclor-induced rat liver S9 mix and the endogenous activity of the treated cells. Both BZD and DAT were shown to be capable of inducing cell lethality and mitotic gene conversion at maximal levels in metabolically active yeast cells grown in high glucose conditions. However, in stationary phase cells the two test chemicals showed differences in responses, with BZD showing activity only in the presence of exogenous S9 mix, whereas DAT showed maximum activity in the absence of the exogenous S9 mix.
The results presented here indicate that in spite of the structural similarity between BZD and DAT they have different metabolic requirements in yeast for the production of genetic activity.
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Notes
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© 1985 United Kingdom Environmental Mutagen Society
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Parry, J.M. (1985). The Genotoxicity of BZD and DAT in Yeast Strain D7. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_28
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DOI: https://doi.org/10.1007/978-1-349-07901-8_28
Publisher Name: Palgrave Macmillan, London
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Online ISBN: 978-1-349-07901-8
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