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The Genotoxicity of Benzidine and 4-Dimethylaminoazobenzene: A Survey of the Literature

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Comparative Genetic Toxicology

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Abstract

A survey of the available mutagenicity literature on the two previously defined, activation-dependent carcinogens used in the Second UKEMS Collaborative Genotoxicity Study was performed using the Environmental Mutagen Information Centre (EMIC) files. Both benzidine and 4-dimethylaminoazobenzene each has in excess of 200 listings. A summary to illustrate the range of assay systems which have been used to investigate the genotoxicity of these compounds was compiled and has been used to generate tables 1 and 2. The classification of the genetic system was basically that used by EMIC for its assay system/biological endpoint category.

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  1. Agrelo, C. and Arnos, H. (1981). Nuclear enlargement in HeLa cells. Progr. Mutat. Res. 1: 245–248

    CAS  Google Scholar 

  2. Agrelo, C. and Arnos, H. (1981). DNA repair in human fibroblasts. Progr. Mutat. Res. 1: 528–532

    CAS  Google Scholar 

  3. Agrelo, CE. and Severn, B.J. (1981). A simplified method for measuring scheduled and unscheduled DNA synthesis in human fibroblasts. Toxicology 21: 151–158

    Article  PubMed  CAS  Google Scholar 

  4. Altenburg, L.S. and Altenburg, E. (1957). The mutagenicity of 4-dimethylaminoazobenzene (Butter Yellow) in Drosophila. Genetics 42: 358–359

    Google Scholar 

  5. Althaus, F.R., Lawrence, S.D., Sattler, G.L., Longfellow, D.G. and Pitot, H.C. (1982). Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens. Cancer Res. 42: 3010–3015

    PubMed  CAS  Google Scholar 

  6. Amlacher, E. and Rudolph, Ch. (1978). Nuclear DNA synthesis rate and labelling index: effects of carcinogenic and non-carcinogenic chemicals on its behaviour in the organism of growing CBA mice. The thymidine incorporation screening system (TTS). Exp. Pathol. 16: 69–82

    CAS  Google Scholar 

  7. Amlacher, E. and Ziebarth, D. (1979). Effectiveness in the carcinogenicity prescreening. Partial comparison of the bacterial mutagenicity test (Ames), the thymidine incorporation inhibiting screening system (Amlacher) and the promoting activity test (Danz). Arch Geschwulstforsch. 49: 490–494

    PubMed  CAS  Google Scholar 

  8. Anderson, R.S. and Doos, J.E. (1983). Activation of mammalian carcinogens to bacterial mutagens by microsomal enzymes from a pelecypod mollusk, Mercenaria mercenaria. Mutation Res. 116: 247–256

    Article  PubMed  CAS  Google Scholar 

  9. Ashby, J., Styles, J.A., Anderson, D. and Paton, D. (1978). Thiophene analogues of the carcinogens benzidine and 4-aminobiphenyl: evaluation in vitro. Brit. J. Cancer38: 521–529

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  10. Ashby, J., Lefevre, P.A., Styles, J.A., Charlesworth, J. and Paton, D. (1982). Comparisons between carcinogenic potency and mutagenic potency to Salmonella in a series of derivatives of 4-dimethylaminoazobenzene (DAB). Mutation Res. 93: 67–81

    Article  PubMed  CAS  Google Scholar 

  11. Baker, R.S.V., Mitchell, G.A., Meher-Homji, K.M. and Podobna, E. (1983). Sensitivity of two Chinese hamster cell lines in SCE induction by a variety of chemical mutagens. Mutation Res. 118: 103–116

    Article  PubMed  CAS  Google Scholar 

  12. Bolognesi, C, Cesarone, C.F. and Santi, L. (1980). DNA damage and repair induced in vivo by benzidine treatment. Boll. Soc. Ital. Biol. Sper. 56: 1673–1679

    PubMed  CAS  Google Scholar 

  13. Bolognesi, C, Cesarone, C.F. and Santi, L. (1981). Evaluation of DNA damage by alkaline elution technique after in vivo treatment with aromatic amines. Carcinogenesis 2: 265–268

    Article  PubMed  CAS  Google Scholar 

  14. Bos, R.P., Neis, J.M., Van Gemert, P.J.L. and Henderson, P.Th. (1983). Mutagenicity testing with the Salmonella/ hepatocyte and the Salmonella/microsome assays, a comparative study with some known genotoxic compounds. Mutation Res. 124: 103–112

    Article  PubMed  CAS  Google Scholar 

  15. Bos, R.P., Brouns, R.M.E., Van Doorn, R., Theuws, J.L.G. and Henderson, P.Th. (1980). The appearance of mutagens in urine of rats after the administration of benzidine and some other aromatic amines. Toxicology 16: 113–122

    Article  PubMed  CAS  Google Scholar 

  16. Bos, R.P., Van Doom, R., Yih-van de Hurk, E., Van Gemert, P.J.L. and Henderson, P.Th. (1982). Comparison of the mutagenicities of 4-aminobiphenyl and benzidine in the Salmonella/microsome, Salmonella/hepatocyte and host-mediated assays. Mutation Res. 93: 317–325

    Article  CAS  Google Scholar 

  17. Brooks, T.M. and Dean, B.J. (1981). Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay with preincubation. Progr. Mutat. Res. 1: 261–270

    CAS  Google Scholar 

  18. Brouns, R.E., Poot, M., De Vrind, R., Hoek-kon, Th.V. and Henderson, P.Th. (1979). Measurement of DNA-excision repair in suspensions of freshly isolated rat hepatocytes after exposure to some carcinogenic compounds. Its possible use in carcinogenicity screening. Mutation Res. 64: 425–432

    Article  PubMed  CAS  Google Scholar 

  19. Burrell A.D., Howard, M.A. and Andersen, J.J. (1978). Metabolic activation of UV-mimetic carcinogens in a differential toxicity test using cultured human cells. Program and Abstracts, 9th Annu. Mtg. EMS 38

    Google Scholar 

  20. Carver, J.H., Salazar, E.P., Knize, M.G. and Wandres, D.L. (1981). Mutation induction at multiple loci in Chinese hamster ovary cells: the genetic activity of 15 coded carcinogens and noncarcinogens. Progr. Mutat. Res. 1: 594–601

    CAS  Google Scholar 

  21. Chauveau, J., Decloitre, F., Benoit, A. and Martin, M. (1977). Relationship between azodye carcinogenicity and induction of repairable damage of DNA in rat liver. Colloq. Int. CNRS 256: 417–430

    Google Scholar 

  22. Cihak, R. (1979). Evaluation of benzidine by the micronucleus test. Mutation Res. 67: 383–384

    Article  PubMed  CAS  Google Scholar 

  23. Cotruvo, J.A., Simmon, V.F. and Spanggord, R.J. (1977). Investigation of mutagenic effects of products of ozonation reactions in water. Ann. N.Y. Acad. Sci. 298: 124–140

    Article  CAS  Google Scholar 

  24. Dambly, C, Toman, Z. and Radman, M. (1981). Zorotest. Progr. Mutat. Res. 1: 219–223

    CAS  Google Scholar 

  25. Daniel, M.R. and Dehnel, J.M. (1981). Cell transformation test with baby hamster kidney cells. Progr. Mutat. Res. 1: 626–637

    CAS  Google Scholar 

  26. Danz, M. and Urban, H. (1979). Carcinogens, promotors and suspicious drugs: their identical short-term effect in a promoting activity test (PAT). Exp. Pathol. 17: 181–184

    CAS  Google Scholar 

  27. Danz. M., Urban, H., Schmidt, A. and Ziebarth, D. (1978). A possible short-term prediction of potential carcinogenicity of compounds in vivo by means of a promoting activity test (PAT). Exp. Pathol. 16: 109–120 28.

    CAS  Google Scholar 

  28. Dean, B.J. (1981). Activity of 27 coded compounds in the RL1 chromosome assay. Progr. Mutat. Res. 1: 570–579

    CAS  Google Scholar 

  29. Decloitre, F., Martin, M. and Chauveau, J. (1975). Comparative effect of phenobarbital and 3-methyl-cholanthrene on azo dye metabolism in rat liver. 2. In vivo binding of metabolites to cellular macromolecules. Chem. Biol. Interact. 10: 301–307

    Article  PubMed  CAS  Google Scholar 

  30. Dehnel, J.M., Daniel, M.R. and Richold, M. (1982). Comparison of the response of BHK21 C13 cells to 4-chloromethyl-biphenyl, 4-hydroxymethylbiphenyl and benzyl chloride in a cell transformation test. Mutation Res. 100: 223–226

    Article  PubMed  CAS  Google Scholar 

  31. Demerec, M., Witkin, E.M., Newcombe, H.B. and Beale, G.H. (1947). The gene. Carnegie Inst. Washington Yearbook46: 127–135

    Google Scholar 

  32. Demerec, M., Wallace, B., Witkin, E.M. and Bertani, G. (1949). The gene. Carnegie Inst. Washington Yearbook48: 154–166

    Google Scholar 

  33. Dunkel, V.C. (1979). Collaborative studies on the Salmonella/ microsome mutagenicity assay. J. Assoc. Off. Anal. Chem. 62: 874–882

    PubMed  CAS  Google Scholar 

  34. Egilsson, V., Evans, I.H. and Wilkie, D. (1979). Toxic and mutagenic effects of carcinogens on the mitochondria of Saccharomyces cerevisiae. Mol. Gen. Genet. 174: 39–46

    Article  PubMed  CAS  Google Scholar 

  35. Elis, J. and Raskova, H. (1964). Indirect indication to the potential carcinogenicity of drugs. Proc. Eur. Soc. Study Drug Toxic. 3: 41–50

    CAS  Google Scholar 

  36. Epstein, S.S. and Shafner, H. (1968). Chemical mutagens in the human environment. Nature 219: 385–387

    Article  PubMed  CAS  Google Scholar 

  37. Epstein, S.S., Arnold, E., Andrea, J., Bass, W. and Bishop. Y. (1972). Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol. Appl. Pharmacol. 23: 288–325

    Article  PubMed  CAS  Google Scholar 

  38. Evans, E.L. and Mitchell, A.D. (1981). Effects of 20 coded chemicals on sister chromatid exchange frequencies in cultured Chinese hamster cells. Progr. Mutat. Res. 1: 538–550

    CAS  Google Scholar 

  39. Fahmy, M.J., and Fahmy, O.G. (1977). Mutagenicity of hair dye components relative to the carcinogen benzidine in Drosophila melanogaster. Mutation Res. 56: 31–38

    Article  PubMed  CAS  Google Scholar 

  40. Fahmy, O.G. and Fahmy, M.J. (1972). Genetic properties of substituted derivatives of N-methyl-4-aminoazobenzene in relation to azo-dye carcinogenesis. Int. J. Cancer 10: 194–206

    Article  PubMed  CAS  Google Scholar 

  41. Fey, E.G., White, H.,A. and Rabin, B.R. (1981). Development of the degranulation test system. Progr. Mutat. Res. 1: 236–244

    CAS  Google Scholar 

  42. Fonshtein, L.M., Abilev, S.K. and Akin’shina, L.P. (1978). Study of metabolic activation of chemicals using microorganisms. 1. Effect of the inducers of microsomal systems. Genetika 14: 1564–1570

    PubMed  CAS  Google Scholar 

  43. Fonshtein, L.M., Revazova, Yu.A., Zolotareva, G.N., Abilev, S.K., Akin’shina, L.N., Bratslavskii, V.A., Iskhakova, E.N., Meskin, V.A., Radchenko, L.U. and Shapiro, A.A. (1978). Studies of mutagenic activity of dioxydine. Soviet Genetics 14: 640–647

    Google Scholar 

  44. Friedrich, U. and Nass, G. (1983). Evaluation of a mutation test using S49 mouse lymphoma cells and monitoring simultaneously the induction of dexamethasone resistance, 6-thioguanine resistance and ouabain resistance. Mutation Res. 110: 147–162

    Article  PubMed  CAS  Google Scholar 

  45. Fritz-Niggli, H. (1954). The production of mutations with carcinogenic substances. ACTA 10: 143–147

    CAS  Google Scholar 

  46. Gershun, V.A., Podgayetskaya, D.Ya. and Fel, V.Ya. (1981). Some antigenic similarity between nonhistone protein-DNA complexes from chromatin of the cells of Zajdela hepatoma and liver of rats subjected to a single 4-dimethylamino-azobenzene injection. Neoplasma 28: 27–34

    PubMed  CAS  Google Scholar 

  47. Green, M.H.L. (1981). A differential killing test using an improved repair-deficient strain of Escherichia coli. Progr. Mutat. Res. 1: 183–194

    CAS  Google Scholar 

  48. Gupta, R.S. and Goldstein, S. (1981). Mutagen testing in the human fibroblast diphtheria toxin resistance (HF Dipr) system. Progr. Mutat. Res. 1: 614–625

    CAS  Google Scholar 

  49. Gupta, R.S. and Singh, B. (1982). Mutagenic responses of five independent genetic loci in CHO cells to a variety of mutagens. Development and characteristics of a mutagen screening system based on selection for multiple drug resistant markers. Mutation Res. 94: 449–466

    Article  PubMed  CAS  Google Scholar 

  50. Huang, S.L. and Waters, M.D. (1983). Induction of 6-thioguanine resistance in human fibroblasts treated with mutagens in the presence of rat liver microsomes. Environ. Mutagen. 5: 414

    Google Scholar 

  51. Ichinotsubo, D., Mower, H. and Mandel, M. (1981). Testing of a series of varied compounds (carcinogen and non-carcinogenic structural analog) by DNA repair-deficient E. coli strains. Progr. Mutat. Res. 1: 195–198

    CAS  Google Scholar 

  52. Jackson, J.F. and Liskens. H.F. (1980). DNA repair in pollen: range of mutagens inducing repair, effect of replication inhibitors and changes in thymidine nucleotide metabolism during repair. Mol. Gen. Genet. 180: 517–522

    Article  CAS  Google Scholar 

  53. Jagannath, D.R., Vultaggio, D.M. and Brusick, D.J. (1981). Genetic activity of 42 coded compounds in the mitotic gene conversion assay using Saccharomyces cerevisiae, strain D4. Progr. Mutat. Res. 1: 456–467

    CAS  Google Scholar 

  54. Jenssen, D. and Ramel, C. (1980). The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 43 agents tested. Mutation Res. 75: 191–202

    Article  PubMed  CAS  Google Scholar 

  55. Jotz, M.M. and Mitchell, A.D. (1981). Effects of 20 coded chemicals on the forward mutation frequency at the thymidine kinase locus in L5178Y mouse lymphoma cells. Progr. Mutat. Res. 1: 580–593

    CAS  Google Scholar 

  56. Kada, T. (1981). The DNA-damaging activity of 42 coded compounds in the rec-assay. Progr. Mutat. Res. 1: 175–182

    CAS  Google Scholar 

  57. Kada, T., Tutikawa, K., and Sadaie, Y. (1972). In vitro and host-mediated ‘rec-assay’ procedures for screening chemical mutagens: and phloxine a mutagenic red dye detected. Mutation Res. 16: 165–174

    Article  PubMed  CAS  Google Scholar 

  58. Kassinova, G.V., Kovaltsova, S.V. Marfin, S.V. and Zakharov, I.A. (1981). Activity of 40 coded compounds in differential inhibition and mitotic crossing-over assays. Progr. Mutat. Res. 1: 434–455

    CAS  Google Scholar 

  59. Kirkhart, B. (1981). Micronucleus test on 21 compounds. Progr. Mutat. Res. 1: 698–704

    CAS  Google Scholar 

  60. Knapp, A.G.A.C., Goze, C. and Simons, J.W.I.M. (1981). Mutagenic activity of 7 coded samples in V79 Chinese hamster cells. Progr. Mutat. Res. 1: 608–613

    Google Scholar 

  61. Kosako, M. and Nishioka, H. (1982). New forward mutation assay using low-concentration streptomycin resistance mutation in E. coli strains with plasmid pKM101. Sci. Eng. Rev. Doshisha Univ. 22: 239–249

    Google Scholar 

  62. Loprieno, N. (1981). Screening of coded carcinogenic-noncarcinogenic chemicals by a forward mutation system with yeast Schizosaccharomyces pombe. Progr. Mutat. Res. 1: 424–433

    CAS  Google Scholar 

  63. Mamber, S.W., Bryson, V. and Katz, S.E. (1984). Evaluation of the Escherichia coli K12 inductest for detection of potential chemical carcinogens. Mutation Res. 130: 141–151

    Article  PubMed  CAS  Google Scholar 

  64. Martin, C.N. and Ekers, S.F. (1980). Studies on the macromolecular binding of benzidine. Carcinogenesis 1: 101–109

    Article  PubMed  CAS  Google Scholar 

  65. Martin, C.N. and McDermid, A.C. (1981). Testing of 42 coded compounds for their ability to induce unscheduled DNA repair synthesis in HeLa cells. Progr. Mutat. Res. 1: 533–537

    CAS  Google Scholar 

  66. Martin, C.N., Beland, F.A., Roth, R.W. and Kadlubar, F.F. (1982). Covalent binding of benzidine and N-acetyl-benzidine to DNA at the C-8 atom of deoxyguanosine in vivo and in vitro. Cancer Res. 42: 2678–2686

    PubMed  CAS  Google Scholar 

  67. Masahito, P. Takayama, S. and Yamada, K. (1976). Early cytological changes induced in rat liver cells by chemicals. Fundam. Cancer Prev. 6th Symp. Princess Takamatsu Cancer Res. Fund (1975): 103–111 Resolution: Global

    Google Scholar 

  68. McQueen, C.A. and Williams, G.M. (1983). Susceptibility of hepatocytes from rapid and slow acetylator rabbits to the genotoxicity of aromatic amines. Environ. Health. Perspect. 49: 240

    Google Scholar 

  69. McQueen, CA., Kreiser, D.M. and Williams, G.M. (1983). The hepatocyte primary culture/DNA repair assay using mouse or hamster hepatocytes. Environ. Mutagen. 5: 1–8

    Article  PubMed  CAS  Google Scholar 

  70. Mehta, R.D. and von Borstal, R.C. (1981). Mutagenic activity of 42 encoded compounds in the haploid yeast reversion assay strain XV185–14C. Progr. Mutat. Res. 1: 414–423

    CAS  Google Scholar 

  71. Mikol, Y.B., Roux, F., Decloitre, F. and Fournier, E.P. (1980). Liver-enzyme induction in lindane-and captan-treated rats. Food Cosmet. Toxicol. 18: 377–382

    Article  PubMed  CAS  Google Scholar 

  72. Mirsalis, J.C., Tyson, C.K. and Butterworth, B.E. (1982). Detection of genotoxic carcinogens in the in vivo — in vitro hepatocyte DNA repair assay. Environ. Mutagen. 4: 553–562

    Article  PubMed  CAS  Google Scholar 

  73. Mohn, G.R., Vogels-Bouter. S. and van der Horst-van der Zon, J. (1981). Studies on the mutagenic activity of 20 coded compounds in liquid tests using the multipurpose strain Escherichia coli K-12/343/113 and derivatives. Progr. Mutat. Res. 1: 396–413

    CAS  Google Scholar 

  74. Müller, D. (1980). Validity of test systems used in the detection of mutagenic and carcinogenic properties of chemical substances. Short-term Tests Chem. Carcinog. 1981: 141–159

    Google Scholar 

  75. Natarajan, A.T. and van Kesteren-van Leeuwen, A.C. (1981). Mutagenic activity of 20 coded compounds in chromosome aberrations/sister chromatid exchanges assay using Chinese hamster ovary (CHO) cells. Progr. Mutat. Res. 1: 551–559

    CAS  Google Scholar 

  76. Natarajan, A.T. and Obe, G. (1982). Mutagenicity testing with cultured mammalian cells: cytogenetic assays. Mutagen. New Horiz. Genet. Toxicol. 1982: 171–213

    Google Scholar 

  77. Paika, I.J., Beauchesne, M.T., Randall, M., Schreck, R.R. and Latt, S.A. (1981). In vivo SCE analysis of 20 coded compounds. Progr. Mutat. Res. 1: 673–681

    CAS  Google Scholar 

  78. Painter, R.B. (1978). DNA synthesis inhibition in HeLa cells as a simple test for agents that damage human DNA. J. Environ. Pathol. Toxicol. 2: 65–78

    CAS  Google Scholar 

  79. Painter, R.B. (1981). DNA synthesis inhibition in mammalian cells as a test for mutagenic carcinogens. Short-term Tests Chem. Carcinog. 1981: 59–64

    Article  Google Scholar 

  80. Painter, R.B. and Howard, R. (1982). The HeLa DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens. Mutation Res. 92: 427–437

    Article  PubMed  CAS  Google Scholar 

  81. Parodi, S., Zunino, A., Ottaggio, L., de Farrari, M. and Santi, L. (1983). Lack of correlation between the capability of inducing sister-chromatid exhanges in vivo and carcinogenic potency for 16 aromatic amines and azo derivatives. Mutation Res. 108: 225–238

    Article  PubMed  CAS  Google Scholar 

  82. Parodi, S., Taningher, M., Russo, P., Pala, M., Tamaro, M. and Monti-Bragadin, C. (1981). DNA-damaging activity in vivo and bacterial mutagenicity of 16 aromatic amines and azo-derivatives, as related quantitatively to their carcinogenicity. Carcinogenesis 2: 1317–1326

    Article  PubMed  CAS  Google Scholar 

  83. Parry, J.M. and Sharp, D. (1981). Induction of mitotic aneuploidy in the yeast strain D6 by 42 coded compounds. Progr. Mutat. Res. 1: 468–480

    CAS  Google Scholar 

  84. Pienta, R.J. (1980). Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities. Chem. Mutagens: Prin. Methods Their Detection 6: 175–202

    Article  CAS  Google Scholar 

  85. Price, P.J. and Mishra, N.K. (1980). The use of Fischer rat embryo cells as a screen for chemical carcinogens and the role of the nontransforming type “C” RNA tumor viruses in the assay. Adv. Mod. Environ. Toxicol. 1: 213–239

    Google Scholar 

  86. Probst, G.S. and Hill, L.E. (1980). Chemically-induced DNA repair synthesis in primary rat hepatocytes: a correlation with bacterial mutagenicity. Ann. N.Y. Acad. Sci. 349: 405–406

    Article  PubMed  CAS  Google Scholar 

  87. Probst, G.S., McMahon, R.E., Hill, L.E., Thompson, C.Z., Epp, J.K. and Neal, S.B. (1981). Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 218 compounds. Environ. Mutagen. 3: 11–32

    Article  PubMed  CAS  Google Scholar 

  88. Rees, K.R., Rowland, G.F., Varcoe, J.S. and Rodwell, J.I. (1963). Studies in nuclear changes during carcinogenesis. Cancer Res. Campaign, Annu. Rep. 41 (pt.2): 340–341

    Google Scholar 

  89. Rickart, R., Appel, K.E., Schwarz, M., Stoeckle, G. and Kunz, W. (1980). Correlations between primary effects of xenobiotics on liver cells in vitro and their mutagenicity and carcinogenicity in vivo. Short-term Test Syst. Detect Carcinog. Proc. Symp. (1978): 179–189

    Article  Google Scholar 

  90. Robinson, D.E. and Mitchell, A.D. (1981). Unscheduled DNA synthesis response of human fibroblasts, WI-38 cells, to 20 coded chemicals. Progr. Mutat. Res. 1: 517–527

    CAS  Google Scholar 

  91. Rosenkranz, H.S., Hyman, J. and Leifer, Z, (1981). DNA polymerase deficient assay. Progr. Mutat. Res. 1: 210–218

    CAS  Google Scholar 

  92. Salamone, M.F., Heddle, J.A. and Katz, M. (1981). Mutagenic activity of 41 compounds in the in vivo micronucleus assay. Progr. Mutat. Res. 1: 686–697

    CAS  Google Scholar 

  93. Schwarz, M., Hummel, J., Appel, K.E., Rickart, R. and Kunz, W. (1979). DNA damage induced in vivo evaluated with a non-radioactive alkaline elution technique. Cancer Letters6: 221–226

    Article  PubMed  CAS  Google Scholar 

  94. Seiler, J.P. (1981). The testicular DNA-synthesis inhibition test (DSI test). Short-term Tests Chem. Carcinog. 1981: 94–107 Resolution: Global

    Chapter  Google Scholar 

  95. Sharp, D.C. and Parry, J.M. (1981). Induction of mitotic gene conversion by 41 coded compounds using the yeast culture JD1. Progr. Mutat. Res. 1: 491–501

    CAS  Google Scholar 

  96. Sharp, D.C. and Parry, J.M. (1981). Use of repair-deficient strains of yeast to assay the activity of 40 coded compounds. Progr. Mutat. Res. 1: 502–516

    CAS  Google Scholar 

  97. Shooter, K.V. and Venitt, S. (1979). Phosphotriesters in DNA: non-repairable lesions as markers for the early detection of chemical carcinogens in intact animals. Mutation Res. 64: 106

    Article  Google Scholar 

  98. Simmon, V.F. (1979). In vitro assays for recombinogenic activity of chemical carcinogens and related compounds with Saccharomyces cerevisiae D3. J. Natl. Cancer Inst. 62: 901–909

    PubMed  CAS  Google Scholar 

  99. Sina, J.F., Bean, C L, Dysart, G.R., Taylor, V.I. and Bradley, M.O. (1983). Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential. Mutation Res. 113: 357–391

    Article  PubMed  CAS  Google Scholar 

  100. Skopek, T.R., Andon, B.M., Kaden, D.A. and Thilly, W.G. (1981). Mutagenic activity of 42 coded compounds using 8-azoguanine resistance as a genetic marker in Salmonella typhimurium. Progr. Mutat. Res. 1: 371–375

    CAS  Google Scholar 

  101. Slamenova, D., Gabelova, A. (1981). Cell-mediated DNA inhibition and 6-TG mutagenicity of V79 cells with chemical carcinogens. Mutation Res. 85: 280–281

    Article  Google Scholar 

  102. Sonnenbichler, J. (1983). Binding of carcinogenic azo compounds to chromosomal proteins. Naunyn-Schmiedeberg’s Arch. Pharmacol. 324: R2

    Google Scholar 

  103. Sonnenbichler, J. and Reichhart, F. (1978). Interaction of p-dimethylaminoazobenzene with rat liver chromatin and nonhistones. Z. Krebforsch Klin. Onkol. 91: 55–61

    Article  CAS  Google Scholar 

  104. Styles, J.A. (1981). Activity of 42 coded compounds in the BHK-21 cell transformation test. Progr. Mutat. Res. 1: 638–646

    CAS  Google Scholar 

  105. Sugimura, T. and Takayama, S. (1983). Biological actions of nitroarenes in short-term tests on Salmonella, cultured mammalian cells and cultured human tracheal tissues: possible basis for regulatory control. Environ. Health Perspect. 47: 171–176

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  106. Sugimura, T., Nagao, M., Kawachi, T. Honda, M., Yahagi, T., Seino, Y., Sato, S., Matsukura, N., Matsushima, T., Shirai, A., Sawamura, M. and Matsumoto, H. (1977). Mutagen-carcinogens in food with special reference to highly mutagenic pyrolytic products in broiled foods. Cold Spring Harbor Conf. Cell Proliferation 4C: 1561–1577

    Google Scholar 

  107. Swenberg, J.A. (1981). Utilization of the alkaline elution assay as a short-term test for chemical carcinogens. Short-term Tests Chem. Carcinog. 1981. 48–58

    Article  Google Scholar 

  108. Takanaka, K., O’Brien, P.J., Tsuruta, Y. and Rahimtula, A.D. (1982). Tumor promoter stimulated irreversible binding of N-methylaminoazobenzene to polymorphonuclear leukocyte DNA. Cancer Letters 15: 311–315

    Article  PubMed  CAS  Google Scholar 

  109. Tarpley, W.G. (1982). The nucleic acid adducts of the hepatocarcinogenic aromatic amines and amides related to N-methyl-4-aminoazobenzene and N-hydroxy-2-acetylamino-fluorene. Dissertation Abst. Int. B. 43: 1345

    Google Scholar 

  110. Tarpley, W.G., Miller, J.A. and Miller E.C. (1980). Adducts from the reaction of N-benzoyloxy-N-methyl-4-aminoazo-benzene with deoxyguanosine or DNA in vitro and from hepatic DNA of mice treated with N-methyl-or N,N-dimethyl-4-amino-azobenzene. Cancer Res. 40: 2493–2499

    PubMed  CAS  Google Scholar 

  111. Tarpley, W.G., Miller, J.A. and Miller, E.C. (1981). DNA adducts fromed from N-benzoyloxy-N-methyl-4-aminoazoben-zene in vitro and from N,N-dimethyl-4-aminoazobenzene in mouse liver. Natl. Cancer Inst. Monograph. 58: 163–164

    CAS  Google Scholar 

  112. Thompson, J.A. (1981). Mutagenic activity of 42 coded compounds in the lambda induction assay. Progr. Mutat. Res. 1: 224–235

    Google Scholar 

  113. Tohda, H., Horaguchi, K., Takahashi, K., Oikawa, A. and Matsushima, T. (1980). Epstein-Barr virus-transformed human lymphoblastoid cells for study of sister chromatid exchange and their evaluation as a test system. Cancer Res. 40: 4775–4780

    PubMed  CAS  Google Scholar 

  114. Tokiwa, T. and Sato, J. (1976). Effect of long-term administration of 4-dimethylaminoazobenzene on liver cell line derived from rats fed this chemical. Gann 67: 879–883

    PubMed  CAS  Google Scholar 

  115. Tong, C. and Williams, G.M. (1979). Variation in response in the adult rat liver epithelial cell/hypoxanthine-guanine phosphoribosyl transferase (ARL/HGPRTase) mutation assay with different metabolic activation-dependent carcinogens. Environ. Mutagen. 1: 148

    Google Scholar 

  116. Topham, J.C. (1981). Evaluation of some chemicals by the sperm morphology assay. Progr. Mutat. Res. 1: 718–722

    CAS  Google Scholar 

  117. Trzos, R.J., Petzold, G.L., Brunden, M.N. and Swenberg, J.A. (1978). Evaluation of 16 carcinogens in the rat using the micronucleus test. Mutation Res. 58: 79–86

    Article  PubMed  CAS  Google Scholar 

  118. Tsuchimoto, T. and Matter, B.E. (1981). Activity of coded compounds in the micronucleus test. Progr. Mutat. Res. 1: 705–711

    CAS  Google Scholar 

  119. Tweats, D.J. (1981). Activity of 42 coded compounds in a differential killing test using Escherichia coli strains WP2, WP67 (uvrA po1A), and CM871 (uvrA lexA recA). Progr. Mutat. Res. 1: 199–209

    CAS  Google Scholar 

  120. Urwin, C, Richardson, J.C. and Palmer, A.K. (1976). An evaluation of the mutagenicity of the cutting oil preservative Grotan BK. Mutation Res. 40: 43–46

    Article  PubMed  CAS  Google Scholar 

  121. Valencia, R. and Houtchens, K. (1981). Mutagenic activity of 10 coded compounds in the Drosophila sex-linked recessive lethal test. Progr. Mutat. Res. 1: 651–659

    CAS  Google Scholar 

  122. Venitt, S., Crofton-Sleigh, C. (1981). Mutagenicity of 42 coded compounds in a bacterial assay using Escherichia coli and Salmonella typhimurium. Progr. Mutat. Res. 1:351–360

    CAS  Google Scholar 

  123. Vogel, E., Blijleven, W.G.H., Kortselius, M.J.H, and Zijlstra, J.A. (1981). Mutagenic activity of 17 coded compounds in the sex-linked recessive lethal test in Drosophila melanogaster. Progr. Mutat. Res. 1: 660–665

    CAS  Google Scholar 

  124. Von Brandt, J. and Hoehne, G. (1952). On the mutagenic activity of some carcinogenic, cytostatic and antibiotic agents. Naturwissenschaften 39: 283–284

    Article  CAS  Google Scholar 

  125. Watanabe, H.K. and Hashimoto, Y. (1981). Unscheduled DNA synthesis induced by 4-aminoazobenzene, N-hydroxy-4-aminoazobenzene, and their derivatives in primary cultures of rat and mouse hepatocytes. Gann 72: 930–936

    PubMed  CAS  Google Scholar 

  126. Williams, G.M. (1978). Further improvements in the hepatocyte primary culture DNA repair test for carcinogens: detection of carcinogenic biphenyl derivatives. Cancer Letters 4: 69–75

    Article  PubMed  CAS  Google Scholar 

  127. Williams, G.M. (1980). DNA repair and mutagenesis in liver cultures as indicators in chemical carcinogen screening. In: Mammalian cell transformation by chemical carcinogens. Adv. Mod. Envir. Toxicol. 1: 273–296

    CAS  Google Scholar 

  128. Würgler, F.E. and Graf, U. (1981). Mutagenic activity of 10 coded compounds in the Drosophila sex-linked recessive lethal assay. Progr. Mutat. Res. 1: 666–672

    Google Scholar 

  129. Wyrobek, A., Gordon, L. and Watchmaker, G. (1981). Effect of 17 chemical agents including 6 carcinogen/noncarcinogen pairs on sperm shape abnormalities in mice. Progr. Mutat. Res. 1: 712–717

    CAS  Google Scholar 

  130. Yoshikura, H. and Matsushima, T. (1981). MLV test (Integration Enhancement Test) of 42 coded compounds in mouse kidney cells. Progr. Mutat. Res. 1: 647–650

    CAS  Google Scholar 

  131. Zimmermann, F.K. and Scheel, I. (1981). Induction of mitotic gene conversion in strain D7 of Saccharomyces cerevisiae by 42 coded compounds. Progr. Mutat. Res. 1: 481–490

    CAS  Google Scholar 

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Authors and Affiliations

  1. EMIC-UK Office, Genetic Toxicology Research Group, Department of Genetics, University College of Swansea, Singleton Park, Swansea, SA2 8PP, UK

    Eileen Waters

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  1. Eileen Waters
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Editors and Affiliations

  1. Department of Genetics, University College Swansea, UK

    J. M. Parry

  2. MRC Cell Mutation Unit, University of Sussex, UK

    C. F. Arlett

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© 1985 United Kingdom Environmental Mutagen Society

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Waters, E. (1985). The Genotoxicity of Benzidine and 4-Dimethylaminoazobenzene: A Survey of the Literature. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_2

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