A Comparison of the Mutagenicity of Benzidine and 4,4″-Diaminoterphenyl with Uninduced Mouse and Rat Liver S9
A one year carcinogenicity study in Fischer F344 rats (Eldridge et al., this volume) has indicated that benzidine (BZD) induces primarily liver tumours whereas 4,4″-diaminoterphenyl (DAT) induces Zymbal’s gland tumours. Evidence from bacterial mutagenicity studies (Garner et al. 1975; Morton et al., 1979) and from DNA binding studies (Kennelly et al., 1984a) suggests that for BZD the ultimate carcinogenic moiety is not BZD itself but an activated form of the compound after metabolism.
KeywordsCytosol Acetyl Diacetyl Carcinogenicity Benzidine
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- Kennelly, J.C., Stanton, C.A. and Martin, C. (1984b). The effect of acetyl CoA supplementation on the mutagenicity of benzidines in the Ames assay. Mutation Res. Resolution: Global In pressGoogle Scholar