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A Comparison of the Mutagenicity of Benzidine and 4,4″-Diaminoterphenyl with Uninduced Mouse and Rat Liver S9

  • D. Paes
  • D. Gatehouse
  • D. Tweats

Abstract

A one year carcinogenicity study in Fischer F344 rats (Eldridge et al., this volume) has indicated that benzidine (BZD) induces primarily liver tumours whereas 4,4″-diaminoterphenyl (DAT) induces Zymbal’s gland tumours. Evidence from bacterial mutagenicity studies (Garner et al. 1975; Morton et al., 1979) and from DNA binding studies (Kennelly et al., 1984a) suggests that for BZD the ultimate carcinogenic moiety is not BZD itself but an activated form of the compound after metabolism.

Keywords

Aromatic Amine Liver Cytosol Bacterial Mutagen Carcinogenicity Study Mutagenic Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

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Copyright information

© United Kingdom Environmental Mutagen Society 1985

Authors and Affiliations

  • D. Paes
    • 1
  • D. Gatehouse
    • 1
  • D. Tweats
    • 1
  1. 1.Glaxo Group ResearchWareUK

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