24-hour Secretory Pattern of ACTH and β-Endorphin in Episodic Cluster Headache
A dyschronical hypothesis of cluster headache (CH) has been recently proposed on the basis of either the cyclical course of clus ter periods and attacks or on the prophylactic effect exerted by Lithium and sleep deprivation known to affect biorhythms (Medina and Diamond, 1981; Nappi et al., 1981). This hypothesis implies a vulnerability of CNS oscillators with a time-structure alteration of the neurotransmitters and neuro-hormones involved in adaptive responses. Thus, headache occurs when these unbalanced systems are forced by environmental cyclic stimuli to phase shift or to cope with new performances. In previous works (Ferrari et al., 1983; Polleri et al., 1982) we observed a lack or an altered rhythmicity of several autonomic and neuroendocrine functions in CH subjects. A deeper involvement was found in subjects with chronic CH who presented a higher occurrence and a larger number of altered biorhythms when compared with episodic CH.
KeywordsCluster Headache Sleep Deprivation Plasma Cortisol ACTH Secretion Chronic Cluster Headache
Unable to display preview. Download preview PDF.
- — Ferrari, E., Canepari, C, Bossolo, P.A., Vailati, A., Martignoni, E., Micieli, G. and Nappi, G. (1983). Changes of biological rhythms in primary headache syndromes. In Chronobiological Correlates of Headache, (eds. G. Nappi and O. Sjaastad). Cephalalgia Suppl. 1, Universitetsforlaget, Oslo.Google Scholar
- — Medina, J.L. and Diamond, S. (1981). The concept of cyclical migraine. In Progress in Migraine Research 1 (eds. F. Clifford Rose and K.J. Zilka). Pitman, London.Google Scholar
- — Nappi, G., Ferrari, E., Polleri, A., Savoldi F. and Vailati, A. (1981). Chronobiological study in cluster headache. Chronobiol. 2, 140Google Scholar
- — Nappi, G., Facchinetti, F., Bono, G., Petraglia, F., Micieli, G., Volpe, A. and Genazzani, A.R. (1983). Lack of —Endorphin and — Lipotropin circadian rhythmicity in episodic cluster headache: a model for chronopathology. Proc. 1st Intern. Headache Congress, Munich, Sept. 1983 (in press).Google Scholar