24-hour Secretory Pattern of ACTH and β-Endorphin in Episodic Cluster Headache
A dyschronical hypothesis of cluster headache (CH) has been recently proposed on the basis of either the cyclical course of clus ter periods and attacks or on the prophylactic effect exerted by Lithium and sleep deprivation known to affect biorhythms (Medina and Diamond, 1981; Nappi et al., 1981). This hypothesis implies a vulnerability of CNS oscillators with a time-structure alteration of the neurotransmitters and neuro-hormones involved in adaptive responses. Thus, headache occurs when these unbalanced systems are forced by environmental cyclic stimuli to phase shift or to cope with new performances. In previous works (Ferrari et al., 1983; Polleri et al., 1982) we observed a lack or an altered rhythmicity of several autonomic and neuroendocrine functions in CH subjects. A deeper involvement was found in subjects with chronic CH who presented a higher occurrence and a larger number of altered biorhythms when compared with episodic CH.
KeywordsCatheter Lithium Migraine Cortisol Prolactin
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