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The Generation of Lyso-PAF in Experimental Inflammation

  • L. Parente
  • R. J. Flower
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

During the last few years increasing experimental evidence has accumulated which indicates that PAF-acether (AGEPC, 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is a potential mediator of inflammation and anaphylaxis (1,2). In chapter 6 of this book Page and co-workers give evidence that PAF-acether fulfils most of the criteria appropriate for an inflammatory mediator. Among these criteria, however, there are two points that await further support by experimental data. Firstly, the generation of PAF-acether during inflammation has been only scantily documented. Secondly, there is no evidence that the inhibition of the release or the actions of PAF-acether leads to an anti-inflammatory effect.

Keywords

Platelet Activate Factor Leukocyte Migration Sham Animal Glyceryl Ether Experimental Inflammation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Vargaftig, B.B., Chignard, M., Benveniste, J., Le Fort, J. and Wal, F. (1981). Background and present status of research on platelet-activating factor (PAF-acether). Ann. N.Y. Acad. Sci., 370, 119–137.Google Scholar
  2. 2.
    Pinckard, R.N., McManus, L.M. and Hanahan, D.J. (1982). Chemistry and biology of acetyl glyceryl ether phosphorylcholine (platelet activating factor). In Advances in Inflammation Research, (ed. G. Weissman). Raven Press, New York, pp. 147–180.Google Scholar
  3. 3.
    Mencia-Huerta, J-M., Roubin, R., Morgat, J-L. and Benveniste, J. (1982). Biosynthesis of platelet-activating factor (PAF-acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages. J. Immunol., 129, 804–808.Google Scholar
  4. 4.
    Albert, D.H. and Snyder, F. (1983). Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) from 1-alkyl-2-acyl-sn-glycero-3 phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation. J. Biol. Chem., 258, 97–102.Google Scholar
  5. 5.
    Parente, L. and Flower, R.J. (1985). Hydrocortisone and “macrocortin” inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. Life Sci., 36, 1225–1231.CrossRefGoogle Scholar
  6. 6.
    Blank, M.L., Lee, T-C, Fitzgerald, V. and Snyder, F. (1981). A specific acetyl-hydrolase for l-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid). J. Biol. Chem., 256, 175–178.Google Scholar
  7. 7.
    Parente, L., Koh, M.S., Willoughby, D.A. and Kitchen, A. (1979). Studies on cell motility in inflammation. I. The chemotactic activity of experimental inflammatory exudates. Agents Actions, 9, 190–195.CrossRefGoogle Scholar
  8. 8.
    Parente, L. and Flower, R.J. (1985). Manuscript in preparation.Google Scholar
  9. 9.
    Blackwell, G.J., Carnuccio, R., Di Rosa, M., Flower, R.J., Langham, C.S.J., Parente, L., Persico, P., Russell-Smith, N.C. and Stone, D. (1982). Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat. Br. J. Pharmac, 76, 185–194.CrossRefGoogle Scholar

Copyright information

© The Contributors 1985

Authors and Affiliations

  • L. Parente
  • R. J. Flower

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