The Generation of Lyso-PAF in Experimental Inflammation
During the last few years increasing experimental evidence has accumulated which indicates that PAF-acether (AGEPC, 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is a potential mediator of inflammation and anaphylaxis (1,2). In chapter 6 of this book Page and co-workers give evidence that PAF-acether fulfils most of the criteria appropriate for an inflammatory mediator. Among these criteria, however, there are two points that await further support by experimental data. Firstly, the generation of PAF-acether during inflammation has been only scantily documented. Secondly, there is no evidence that the inhibition of the release or the actions of PAF-acether leads to an anti-inflammatory effect.
KeywordsMigration Acetone Corticosteroid Chloroform Hydrocortisone
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