Abstract
The yeast-inflamed rat paw model (1) has been used extensively to evaluate analgesic agents and a role for prostaglandins as mediators of hyperalgesia in this model is well accepted. In 1965 Winter and Flataker (2) showed that non-steroidal anti-inflammatory drugs inhibited the yeast-induced hyperalgesia without affecting oedema and later, Tyers and Haywood (3) proposed that prostaglandins, in particular PGE2, acted by sensitising primary afferent neurones to stimulation by other nociceptive agents. More recently, attention has focused on the possible role of lipoxygenase metabolites as mediators of hyperalgesia and oedema in this model. Rackham and Ford-Hutchinson (4) showed that LTB4 reversed the initial hypoalgesia and shortened the onset of hyperalgesia when injected concomitantly with yeast, in a similar manner to PGE1. However, rather than having a pro-inflammatory effect, LTB4 reduced the yeast-induced oedema. In similar experiments, line peptidyl leukotriene, LTD4, had no effect on yeast-induced hyperalgesia or oedema.
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Haworth, D., Carey, F. (1985). Identification of Immunoreactive LTB4 in the Yeast-inflamed Rat Paw. In: Higgs, G.A., Williams, T.J. (eds) Inflammatory Mediators. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07834-9_4
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DOI: https://doi.org/10.1007/978-1-349-07834-9_4
Publisher Name: Palgrave Macmillan, London
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