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The Synthesis and Inhibition of Eicosanoids in Inflammation

  • Chapter
Inflammatory Mediators

Abstract

The interest of pharmacologists and physiologists in biologically active lipids has led to the discovery of two important families of mediators, the prostaglandins and the leukotrienes. Both these groups of compounds have a twenty carbon backbone and they have, therefore, become known collectively as the eicosanoids. Prostaglandins and leukotrienes are products of lipid peroxidation following the liberation of polyunsaturated fatty acids from tissue phospholipids. These oxidative processes appear to accompany tissue damage and injury caused by a wide variety of stimuli and as a consequence, eicosanoid synthesis is an integral part of the inflammatory response. In this chapter, we shall review the evidence for eicosanoid production in experimental inflammation and inflammatory diseases and indicate how the potent biological properties of prostaglandins and leukotrienes contribute to the inflammatory response. We shall also discuss the mechanism of action of anti-inflammatory drugs which interfere with the synthesis of eicosanoids.

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Authors
  1. G. A. Higgs
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  2. B. Henderson
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  3. S. Moncada
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  4. J. A. Salmon
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Editors and Affiliations

  1. Department of Mediator Pharmacology, The Wellcome Research Laboratories, Beckenham, Kent, UK

    G. A. Higgs

  2. Section of Vascular Biology, Medical Research Council, Clinical Research Centre, Northwick Park, Harrow, Middlesex, UK

    T. J. Williams

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Higgs, G.A., Henderson, B., Moncada, S., Salmon, J.A. (1985). The Synthesis and Inhibition of Eicosanoids in Inflammation. In: Higgs, G.A., Williams, T.J. (eds) Inflammatory Mediators. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07834-9_3

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