Skip to main content
SpringerLink
Log in

Interleukin-1 in Arthritis

  • Chapter
Inflammatory Mediators

  • 105 Accesses

Abstract

The hypothesis is reviewed that interleukin-1 (IL-1) may contribute to the pathology of rheumatoid arthritis. IL-1 is a protein mediator secreted by cells of the macrophage lineage among others. Although the activity of IL-1 is shared by a variety of proteins with different molecular weights and isoelectric points, it is likely that the various biochemical species are all products of a single gene. IL-1 is predominantly recognised for the role it plays in the body’s defence against infection as a stimulant of immune response, neutrophil activation, acute phase changes, and fever. Recently, however, it has become clear that in vitro IL-1 can also modulate the activity of many of the mesenchymal cells which contribute to the architecture of the articular joint. If these activities were expressed in vivo, they could be responsible for several of the characteristic pathological features of rheumatoid arthritis including the synovial hypertrophy, the high hyaluronate and protease content of the synovial fluid, cartilage destruction, and bone resorption. In fact, it has been possible to recover and identify IL-1 in the synovial fluids of arthritic patients. Although a portion of this IL-1 may be derived from the infiltrating leukocytes, the synovium itself is also capable of releasing large amounts of IL-1. From these results, a model of arthritic disease can be constructed in which IL-1 is hypothesised to play a major role in the maintenance of the chronicity and in the eventual joint destruction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aarden, L.A. et al. (1979). Revised nomenclature for antigen nonspecific T cell proliferation and helper factors. J. Immunol., 123, 2928-2929.

    Google Scholar 

  2. Gery, I. and Waksman, B.H. (1972). Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). J. Exp. Med., 136, 143-155.

    Google Scholar 

  3. Wood, D.D. (1984). Antigen non-specific factors elaborated by macrophages which stimulate lymphocytes: Interleukin 1. In The Reticuloendothelial System, Vol. 6, (eds. J.A. Bellanti and H.B. Herscowitz), Plenum Press, New York, pp. 201-264.

    Google Scholar 

  4. Wood, D.D., Bayne, E.K., Goldring, M.D., Gowen, M., Hamerman, D., Humes, J.L., Lipsky, P.E. and Staruch, M.J. (1985). Molecular heterogeneity of human interleukin-1. II. Biological activities. Submitted to J. Immunol.

    Google Scholar 

  5. Mizel, S.B. (1981). Physic ochemical characterization of lymphocyte-activating factor (LAF). J. Immunol., 122, 2167-2172.

    Google Scholar 

  6. Saklatvala, J. (1981). Characterization of catabolin, the major product of pig synovial tissue that induces resorption of cartilage proteoglycan in vitro. Biochem. J., 199, 705-714.

    Google Scholar 

  7. Lachman, L.B., Hacker, M.P., Blyden, G.T. and Handschumacher, R.E. (1977). Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines. Cell Immunol., 34, 416-419.

    Article  Google Scholar 

  8. Simon, P.L. and Willoughby, W.F. (1981). The role of subcellular factors in pulmonary immune function: Physicochemical characterization of two distinct species of lymphocyte activating factor produced by rabbit alveolar macrophages. J. Immunol., 126, 1534-1541.

    Google Scholar 

  9. Taniyama, T. and Onoue, K. (1983). Physic ochemical properties of T cell-activating monokines in guinea pigs. Cell Immunol., 811, 118-125.

    Article  Google Scholar 

  10. Dinarello, C.A. (1984). Interleukin-1. Reviews Inf. Dis., 6, 51-95.

    Google Scholar 

  11. Mannel, D.N., Farrar, J.J. and Mergenhagen, S.E. (1980). Separation of a serum-derived tumoricidal factor from a helper factor for plaque-forming cells. J. Immunol., 124, 1106-1110.

    Google Scholar 

  12. Bendtzen, K., Baek, L., Berild, D., Hasselbach, H., Dinarello, CA. and Wolff, S.M. (1984). Demonstration of circulating leukocytic pyrogen/interleukin-1 during fever. New Eng. J. Med., 310, 596.

    Google Scholar 

  13. Dayer, J.M., Krane, S.M., Russell, R.G.G. and Robinson, D.R. (1976). Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc.Natl. Acad. Sci. USA, 73, 945-949.

    Article  Google Scholar 

  14. Dayer, J.M., Burne, M.H. and Krane, S.M. (1980). Effects of a mononuclear cell factor (MCF), indomethacin and prostaglandin E2 (PGE2) on collagen and fibronectin synthesis by cultured rheumatoid synovial cells. Clin. Res., 28, 343A.

    Google Scholar 

  15. Mizel, S.B., Dayer, J.M., Krane, S.M. and Mergenhagen, S.E. (1981). Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte activating factor (interleukin-1). Proc. Natl. Acad. Sci. USA, 78, 2474-2477.

    Article  Google Scholar 

  16. McGuire-Goldring, M.B., Meats, J.E., Wood, D.D., Ihrie, E.J., Ebsworth, N.M. and Russell, R.G.G. (1984). In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor. Arth. Rheum., 27, 654-662.

    Article  Google Scholar 

  17. Dayer, J.M., Goldring, S.R., Robinson, D.R. and Krane, S.M. (1979). Effects of human mononuclear cell factor on cultured rheumatoid synovial cell. Biochim. Biophys. Acta., 586, 87-105.

    Google Scholar 

  18. Hamerman, D. and Wood, D.D. (1985). Interleukin-1 enhances synovial cell hyaluronate synthesis. Proc. Soc. Exp. Biol. Med., in press.

    Google Scholar 

  19. Daireaux, M., Penfornis, H., Langris, M., Bocquet, J., Pujol, J.P., Beliard, R. and Loyau, G. (1981). Effect of a mononuclear cell culture medium on collagen and glycosaminoglycan production by synovial cells in culture. FEBS Letters, 132, 93-97.

    Article  Google Scholar 

  20. Wood, D.D. and Cameron, P.M. (1978). Relationship between bacterial endotoxin and human B cell activating factor. J. Immunol., 121., 53-58.

    Google Scholar 

  21. Amento, E.P., Bhan, A.K. and Krane, S.M. (1984). Effects of interferon-gamma and mononuclear cell factor on adherent rheumatoid synovial cells: alterations of Ia expression and collagen synthesis. Arth. Rheum., 27, S23.

    Google Scholar 

  22. Hamilton, J.A., Zabriskie, J.B., Lachman, L.B. and Chen, Y-S. (1982). Streptococcal cell walls and synovial cell activation. J. Exp. Med., 155, 1702-1718.

    Article  Google Scholar 

  23. Deshmukh-Phadke, K., Lawrence, M. and Nanda, S. (1978). Synthesis of collagenase and neutral proteases by articular chondrocytes: Stimulation by a macrophage-derived factor. Biochem. Biophys. Res. Comm., 85, 490-496.

    Google Scholar 

  24. Ridge, S.C., Oronsky, A.L. and Kerwar, S.S. (1980). Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages. Arth. Rheum., 23, 448-454.

    Article  Google Scholar 

  25. Deshmukh-Phadke, K., Nanda, S. and Lee, K. (1980). Macrophage factor that induces neutral protease secretion by normal rabbit chondrocytes. Eur. J. Biochem., 104, 175-180.

    Article  Google Scholar 

  26. Gowen, M., Wood, D.D., Ihrie, E.J., Meats, J.E. and Russell, R.G.G. (1984). Stimulation by human interleukin-1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochim. Biophys. Acta., 797, 186-193.

    Google Scholar 

  27. Gowen, M. (1984). The role of monocyte products in connective tissue turnover. Ph.D. thesis, Univ. Sheffield, U.K.

    Google Scholar 

  28. Kobayashi, I. and Ziff, M. (1975). Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arth. Rheum., 18, 475-483.

    Google Scholar 

  29. Trechsel, V., Dew, G., Murphy, G. and Reynolds, J.J. (1982). Effects of products from macrophages, blood mononuclear cells and of retinol on collagenase secretion and collagen synthesis in chondrocyte culture. Biochim. Biophys. Acta., 720, 364-370.

    Google Scholar 

  30. Pujol, J.P., Brisset, M., Jourdan, C, Borquet, J., Touis, V., Beliard, R. and Loyau, G. (1984). Effect of a monocyte cell factor (MCF) on collagen production in cultured articular chondrocytes: Role of prostaglandin E2. Biochem. Biophys. Res. Comm., 119, 499-508.

    Google Scholar 

  31. Phadke, K., Nanda, S., Marder, P. and Carlson, D.G. (1981). Release of chondrocyte-stimulating factor by rabbit peritoneal macrophages. Clin. Exp. Immunol., 43, 408-416.

    Google Scholar 

  32. Saklatvala, J. and Sarsfield, S.J. (1982). Lymphocytes induce resorption of cartilage by producing catabolin. Biochem. J., 202, 275-278.

    Google Scholar 

  33. Saklatvala, J., Curry, V.A. and Sarsfield, S.J. (1983). Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro. Biochem. J., 215, 385-392.

    Google Scholar 

  34. Moore, R.N., Oppenheim, J.J., Farrar, J.J., Carter, C.S., Jr., Waheed, A. and Shadduck, R.K. (1980). Production of lymphocyte-activating factor (interleukin-1) by macrophages activated with colony-stimulating factors. J. Immunol., 125, 1302-1309.

    Google Scholar 

  35. Wood, D.D. and Gaul, S.L. (1974). Enhancement of the humoral response of T cell derived murine spleens by a factor derived from human monocytes in vitro. J. Immunol., 113, 925-932.

    Google Scholar 

  36. Gowen, M., Meikle, M.C. and Reynolds, J.J. (1983). Stimulation of bone resorption in vitro by a non-prostanoid factor released by human monocytes in culture. Biochim. Biophys. Acta., 762, 471-474.

    Google Scholar 

  37. Gowen, M., Wood, D.D., Ihrie, E.J., McGuire, M.K.B. and Russell, R.G.G. (1983). An interleukin-1-like factor stimulates bone resorption in vitro. Nature, 306, 378-379.

    Article  Google Scholar 

  38. McGuire, M.K.B., Meats, J.E., Ebsworth, N.M., Murphy, G., Reynolds, J.J. and Russell, R.G.G. (1982). Messenger function of prostaglandins in cell to cell interactions and control of proteinase activity in the rheumatoid joint. Int. J. Immunopharmac, 4, 91-102.

    Article  Google Scholar 

  39. Gowen, M., Wood, D.D. and Russell, R.G.G. (1985). Stimulation of the proliferation of human bone cells in vitro by a human monocyte product. Submitted.

    Google Scholar 

  40. Beresford, J.N., Gallagher, J.A., Gowen, M., Couch, M., Poser, J., Wood, D.D. and Russell, R.G.G. (1985). The effect of monocyte conditioned medium and interleukin-1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro. Biochim. Biophys. Acta., in press.

    Google Scholar 

  41. Skjodt, H., Gallagher, J.A., Beresford, J.M., Gowen, M., MacDonald, B.R., Poser, J.W., Wood, D.D. and Russell, R.G.G. (1985). Human bone cell culture: Interaction of 1,25-dihydroxy vitamin D3 and interleukin-1. Proc. Internatl. Symp. Osteoporosis, in press.

    Google Scholar 

  42. Mizel, S.B. and Ben-Zvi, A. (1980). Studies on the role of lymphocyte-activating factor (interleukin-1) in antigen-induced lymph node lymphocyte proliferation. Cell Immunol., 54, 382-389.

    Article  Google Scholar 

  43. Staruch, M.J. and Wood, D.D. (1983). The adjuvanticity of interleukin-1 in vivo. J. Immunol., .130, 2191-2194.

    Google Scholar 

  44. Tominaga, A., Lefort, S., Mizel, S.B., Dambrauskas, J.T., Granstein, R., Lowy, A., Benacerraf, B. and Green, M.I. (1983). Molecular signals in antigen presentation. I. Effects of interleukin-1 and 2 on radiation-treated antigen-presenting cells in vivo and in vitro. Clin. Immunol. Immunpath., 29, 282-293.

    Article  Google Scholar 

  45. Smiley, J.D., Sacks, C. and Ziff, M. (1968). In vitro synthesis of immunoglobulin by rheumatoid synovial membrane. J. Clin. Invest., 47, 624-634.

    Article  Google Scholar 

  46. Stastny, P., Rosenthal, M., Andreis, M. and Ziff, M. (1975). Lymphokines in the rheumatoid joint. Arth. Rheum., 18, 237-243.

    Article  Google Scholar 

  47. Wilkins, J.A., Warrington, R.J., Sigurdson, S.L. and Rutherford, W.J. (1983). The demonstration of an interleukin-2 like activity in the synovial fluids of rheumatoid arthritic patients. J. Rheumat., 10, 190-113.

    Google Scholar 

  48. Sztein, M.B., Vogel, S.N., Sipe, J.D., Murphy, R.A., Mizel, S.B., Oppenheim, J.J. and Rosenstreich, D.L. (1981). The role of macrophages in the acute phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen. Cell Immunol., 64, 164-176.

    Article  Google Scholar 

  49. Luger, T.A., Charon, J.A., Colot, M., Micksche, M. and Oppenheim, J.J. (1983). Chemotactic properties of partially purified human epidermal cell-derived thymocyte-activating factor (ETAF) for polymorphonuclear and mononuclear cells. J. Immunol., 131, 816-820.

    Google Scholar 

  50. Klempner, M.S., Dinarello, CA., Henderson, W.R. and Gallin, J.I. (1979). Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen. J. Clin. Invest., 64, 996-1002.

    Article  Google Scholar 

  51. Bodel, P.T. and Hollingworth, J.W. (1968). Pyrogen release from human synovial exudate cells. Br. J. Exp. Path., 49, 11-19.

    Google Scholar 

  52. Ise, K., Nakamura, S., Ohkawara, S. and Yoshinaga, M. (1982). DNA synthesis-potentiating activity on mouse thymocytes of synovial fluid of rheumatoid arthritis patients. Acta. Pathol., Jpn., 32, 491-503.

    Google Scholar 

  53. Fontana, A., Hengartner, H., Weber, E., Fehr, K., Grob, P.J. and Cohen, G. (1982). Interleukin-1 activity in the synovial fluid of patients with rheumatoid arthritis. Rheumatol. Int., 2, 49-53.

    Google Scholar 

  54. Wood, D.D., Ihrie, E.J., Dinarello, C.A. and Cohen, P.L. (1983). Isolation of an interleukin-1-like factor from human joint effusions. Arth. Rheum., 26, 975-983.

    Article  Google Scholar 

  55. Nouri, A.M., Panayi, G.S. and Goodman, S.M. (1984). Cytokines and the chronic inflammation of rheumatic diseases. I. The presence of interleukin-1 in synovial fluids. Clin. Exp. Immunol., 55, 295-302.

    Google Scholar 

  56. Kampschmidt, R.F. and Upchurch, H.F. (1980). Rate of clearance of circulating leukocytic endogenous mediator in the rat. Proc. Soc. Exp. Biol. Med., 164, 537-539.

    Google Scholar 

  57. Meats, J.E., McGuire, M.B. and Russell, R.G.G. (1980). Human synovium releases a factor which stimulates chondrocyte production of PGE2 and plasminogen activator. Nature, 286, 891-892.

    Article  Google Scholar 

  58. Wood, D.D., Ihrie, E.J. and Hamerman, D. (1985). Production of interleukin-1 by human synovial tissue in vitro. Submitted.

    Google Scholar 

  59. Stuart, J.M., Postlethwaite, A.E., Townes, A.S. and Kang, A.H. (1980). Cell-mediated immunity to collagen and collagen a chains in rheumatoid arthritis and other rheumatic diseases. Am. J. Med., 69, 13-18.

    Google Scholar 

  60. Hamerman, D., Smith, C, Keiser, H.D. and Craig, R. (1982). Glycosaminoglycans produced by human synovial cell cultures. Collagen Rel. Res., 2, 313-329.

    Google Scholar 

Download references

Authors
  1. D. D. Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Mediator Pharmacology, The Wellcome Research Laboratories, Beckenham, Kent, UK

    G. A. Higgs

  2. Section of Vascular Biology, Medical Research Council, Clinical Research Centre, Northwick Park, Harrow, Middlesex, UK

    T. J. Williams

Copyright information

© 1985 The Contributors

About this chapter

Cite this chapter

Wood, D.D. (1985). Interleukin-1 in Arthritis. In: Higgs, G.A., Williams, T.J. (eds) Inflammatory Mediators. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07834-9_15

Download citation

Publish with us

Policies and ethics

Search

Navigation