Resident Macrophages Control Initial Neutrophil Migration in the Acute Inflammatory Response

  • G. E. P. de Souza
  • F. Q. Cunha
  • S. H. Ferreira
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

The objective of this paper is to review some experimental evidence from our laboratory supporting the role of resident macrophages in the modulation of the initial neutrophil migration induced by a variety of stimuli.

Keywords

Migration Acetone Tuberculosis Staphylococcus Mast 

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References

  1. 1.
    Ferreira, S.H., De Souza, G.E.P. and Ribeiro dos Santos, R. (1980). In vivo inhibition of PMN migration by antimacrophage serum. In Inflammation, mechanisms and treatment. Proceedings of the fourth international meeting on future trends in inflammation, (ed. D.A. Willoughby and J.P. Giroud), pp. 789–793.CrossRefGoogle Scholar
  2. 2.
    Coons, A.H. and Kaplan, M.H. (1950). Localization of antigen in tissue cells. II. Improvements in a method for the detection of antigen by means of a fluorescent antibody. J. Exp. Med., 91, 1–13.Google Scholar
  3. 3.
    Ribeiro dos Santos, R. and Hudson, L. (1980). Trypanosoma cruzi: Binding of parasite antigens to mammalian cell membranes. Parasite Immunol., 2, 1.Google Scholar
  4. 4.
    Kazmierowski, J.A., Gallin, J.I. and Reynolds, H.Y. (1977). Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived factor with preferential activity for polymorphonuclear leukocytes. J. Clin. Invest., 59, 273–281.CrossRefGoogle Scholar
  5. 5.
    Russo, M. (1980). The role of macrophages in the chemotactic response of polymorphonuclear leukocytes to bacterial lipopolysaccharides. Proc. Soc. Exp. Biol. Med., 164, 326–330.Google Scholar
  6. 6.
    de Souza, G.E.P. and Ferreira, S.H. (1984). Blockade by antimacrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity (manuscript in preparation).Google Scholar
  7. 7.
    Cunha, F.Q., Cacini, A.T. and Ferreira, S.H. (1984). Endotoxin releases a polymorphonuclear neutrophil chemotactic factor from macrophages. Proc. 2nd Congress of the Brazilian Pharmacology and Exp. Therap. Soc., Braz. J. Med. Biol. Res., in press.Google Scholar
  8. 8.
    Hunninghake, G.W., Gallin, J.I. and Fauci, A.S. (1978). Immunologic reactivity of the lung. The in vivo and in vitro generation of a neutrophil chemotactic factor by alveolar macrophages. Am. Rev. Res. Dis., 117, 15–23.Google Scholar
  9. 9.
    Merrill, W., Naegel, G.P., Matthay, R.A. and Reynolds, H.Y. (1978). Production of chemotactic factor(s) by in vitro cultured human alveolar macrophages. Clin. Res., 26, 635a.Google Scholar
  10. 10.
    McCarthy, K. and Henson, P.M. (1979). Induction of lysosomal enzyme secretion by alveolar macrophages in response to the purified complement fragments C5a and C5a des-arg. J. Immunol., 123, 2511–2517.Google Scholar
  11. 11.
    Merrill, W.W., Naegel, G.P., Matthay, A. and Reynolds, H.Y. (1980). Alveolar macrophage-derived chemotactic factor. Kinetics of in vitro production and partial characterization. J. Clin. Invest., 65, 268–276.CrossRefGoogle Scholar
  12. 12.
    Dauber, J.H. and Daniele, R.P. (1980). Secretion of chemotaxins by guinea-pig lung macrophages. I. The spectrum of inflammatory cell responses. Exp. Lung Res., 1, 23–32.CrossRefGoogle Scholar
  13. 13.
    Valone, F.H., Franklin, M., Sun, F.F. and Goetzl, E.J. (1980). Alveolar macrophage lipoxygenase products of arachidonic acid. Isolation and recognition as the predominant constituents of the neutrophil chemotactic activity elaborated by alveolar macrophages. Cell Immunol., 54, 390–401.CrossRefGoogle Scholar
  14. 14.
    Gadek, J.E., Hunninghake, G.W., Zimmerman, R.L. and Crystal, R.G. (1980). Regulation of the release of alveolar macrophage-derived neutrophil chemotactic factor. Am. Rev. Resp. Dis., 121, 723–733.Google Scholar
  15. 15.
    Hunninghake, G.W., Gadek, J.E. and Lawley, T.J. (1981). Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Invest., 68, 259–269.CrossRefGoogle Scholar
  16. 16.
    Schoenberger, C.I., Hunninghake, G.W., Kawanami, O., Ferrans, V.J. and Crystal, R.G. (1982). Role of alveolar macrophages in asbestosis: modulation of neutrophil migration to the lung after acute asbestos exposure. Thorax, 37, 803–809.CrossRefGoogle Scholar
  17. 17.
    Lugano, E.M., Dauber, J.H. and Daniele, R.P. (1982). Acute experimental silicosis — Lung morphology, histology and macrophage chemotaxin secretion. Am. J. Pathol., 109, 27–36.Google Scholar
  18. 18.
    Kaelin, R.M., Center, D.M., Bernardo, J., Grant, M. and Snider, G.L. (1983). The role of macrophage-derived chemoattractant activities in the early inflammatory events of bleomycin-induced pulmonary injury. Am. Rev. Resp. Dis., 128, 132–137.Google Scholar
  19. 19.
    Adamson, I.Y.R. and Bowden, D.H. (1982). Chemotactic and mitogenic components of the alveolar macrophage response to particles and neutrophil chemoattractant. Am. J. Path., 109, 71–77.Google Scholar
  20. 20.
    Tono-Oka, T., Nakayama, M. and Matsumoto, S. (1980). Human monocyte-derived chemotactic factor for granulocytes. Immunol., 39, 607–613.Google Scholar
  21. 21.
    Boltz-Nitulescu, G. and Forster, O. (1979). Differences in the cytotoxic effect of rabbit anti-rat macrophage sera on rat alveolar and peritoneal macrophages. Immunobiol., 156, 331–341.CrossRefGoogle Scholar
  22. 22.
    Lavelle, K.J., Durland, B.D. and Yum, M.N. (1981). The effect of antimacrophage antiserum on immune complex glomerulonephritis. J. Lab. Clin. Med., 98, 195–205.Google Scholar
  23. 23.
    Ward, P.A., Unanue, E.R., Goralnick, S.J. and Schreiner, G.F. (1977). Chemotaxis of rat lymphocytes. J. Immunol., 119, 416–421.Google Scholar
  24. 24.
    Stevenson, R.D. (1974). Polymorph migration stimulator. A new factor produced by hydrocortisone-treated monocytes. Clin. Exp. Immunol., 17, 601–606.Google Scholar
  25. 25.
    Reynolds, H.Y. (1983). Lung inflammation: Role of endogenous chemotactic factors in attracting polymorphonuclear granulocytes. Am. Rev. Resp. Dis., 127, S16-S25.Google Scholar
  26. 26.
    Ferreira, S.H. (1980). Are macrophages the body’s alarm cells? Agents and Actions, 10, 229–230.CrossRefGoogle Scholar

Copyright information

© The Contributors 1985

Authors and Affiliations

  • G. E. P. de Souza
  • F. Q. Cunha
  • S. H. Ferreira

There are no affiliations available

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