Abstract
The normal growth and differentiation of eukaryotic cells is dependent upon an adequate supply of purine nucleotides. Their role in cellular metabolism is multifaceted, since they serve as substrates for kinase reactions, act as precursors for RNA and DNA synthesis, modulate allosteric enzymes and function as second messengers for hormones, e.g., cyclic AMP and cyclic GMP. All cells, regardless of their state of activity, utilize nitrogenous bases with great economy so that biosynthetic and degradative processes are under precise regulation. Two major routes, designated as the de novo and salvage pathways for the synthesis of purines and pyrimidines have been defined. The de novo pathway utilizes low molecular weight precursors to synthesizepurine and pyrimidine bases required for formation of ribonucleotides. The salvage pathway scavenges free purine and pyrimidine bases produced by hydrolytic breakdown of ribonucleotides and recycles them via a complex series of metabolic reactions (Figure 1).
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Mirkin, B.L., Slomiany, D.J. (1985). Effects of Purines on Cell Growth and Differentiation. In: Stone, T.W. (eds) Purines. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07564-5_24
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DOI: https://doi.org/10.1007/978-1-349-07564-5_24
Publisher Name: Palgrave Macmillan, London
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