Skip to main content
SpringerLink
Log in

Actions and Structure-Activity Relationships of Purines on Platelets

  • Chapter
Purines

  • 119 Accesses

Abstract

Adenosine and adenine nucleotides have pharmacological effects on platelets by interacting with two distinct types of purine receptor, one of which recognises adenosine and one of which recognises adenine nucleotides.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agarwal, K.C. and Parks, R.E. (1982). Biochem. Pharmacol., 31, 3713–3716.

    Article  PubMed  CAS  Google Scholar 

  2. Born, G.V.R. (1962). Nature, 194, 927–929.

    Article  PubMed  CAS  Google Scholar 

  3. Born, G.V.R. (1964). Nature, 202, 95–96.

    Article  PubMed  CAS  Google Scholar 

  4. Born, G.V.R., Haslam, R.J., Goldman, M. and Lowe, R.D. (1965). Nature, 205, 678–680.

    Article  PubMed  CAS  Google Scholar 

  5. Born, G.V.R. and Kratzer, M.A.A. (1984). J. Physiol., in press.

    Google Scholar 

  6. Brown, C., Burnstock, G., Cusack, N.J., Meghji, P. and Moody, C.J. (1982). Br. J. Pharmacol., 75, 101–107.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Bruns, R.F. (1980). Can. J. Physiol. Pharmacol., 58, 673–691.

    Article  PubMed  CAS  Google Scholar 

  8. Burnstock, G. and Brown, C.M. (1981). In Purinergic Receptors: Receptors and Recognition Series B Volume 12. (ed. G. Burnstock). Chapman and Hall, London.

    Book  Google Scholar 

  9. Burnstock, G., Cusack, N.J., Hills, J.M., MacKenzie, I. and Meghji, P. (1983). Br. J. Pharmacol., 79, 907–913.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  10. Burnstock, G., Cusack, N.J. and Meldrum, L.A. (1984). Br. J. Pharmacol., 82, 369–374.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. Colman, R.W. and Figures, W.R. (1984). Mol. Cell. Biochem., 59,

    Google Scholar 

  12. 101–111. Colman, R.W., Figures, W.R., Colman, R.F., Morinelli, T.A., Niewiarowski, S. and Mills, D.C.B. (1980). Trans. Assoc. Am. Phys., 93, 305–316.

    Google Scholar 

  13. Cusack, N.J. and Born, G.V.R. (1976). Proc. R. Soc. Lond. B, 193, 307–311.

    Google Scholar 

  14. Cusack, N.J. and Born, G.V.R. (1977). Proc. R. Soc. Lond. B, 197, 515–520.

    Google Scholar 

  15. Cusack, N.J., Hickman, M.E. and Born, G.V.R. (1979). Proc. R. Soc. Lond. B, 206, 139–144.

    Google Scholar 

  16. Cusack, N.J. and Hourani, S.M.O. (1981a). Br. J. Pharmacol., 72, 443–447.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Cusack, N.J. and Hourani, S.M.O. (1981b). Br. J. Pharmacol., 73, 405–408.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  18. Cusack, N.J. and Hourani, S.M.O. (1981c). Br. J. Pharmacol., 73, 409–412.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  19. Cusack, N.J. and Hourani, S.M.O. (1982a). Br. J. Pharmacol., 75, 257–259.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Cusack, N.J. and Hourani, S.M.O. (1982b). Br. J. Pharmacol., 75, 397–400.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  21. Cusack, N.J. and Hourani, S.M.O. (1982c). Br. J. Pharmacol., 76, 221–227.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  22. Cusack, N.J. and Hourani, S.M.O. (1982d). Br. J. Pharmacol., 77, 329–333.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  23. Cusack, N.J. and Hourani, S.M.O. (1984). Br. J. Pharmacol., 82, 155–159.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  24. Cusack, N.J. and Planker, M. (1979). Br. J. Pharmacol., 67, 153–158.

    PubMed  CAS  PubMed Central  Google Scholar 

  25. Fredholm, B.B. and Sandberg, G. (1983). Br. J. Pharmacol., 80, 639–644.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  26. Gough, G., Maguire, M.H. and Penglis, F. (1972). Mol. Pharmacol., 8, 170–177.

    PubMed  CAS  Google Scholar 

  27. Gough, G., Nobbs, D.M., Middleton, J.C., Penglis-Caredes, F. and Maguire, M.H. (1978). J. Med. Chem., 21, 520–525.

    Google Scholar 

  28. Harris, D.N., ksaad, M.M., Phillips, M.B., Goldenberg, H.J. and Antonaccio, M.J. (1979). J. Cyclic Nuc. Res., 5, 125–134.

    Google Scholar 

  29. Harrison, M.J. and Brossmer, R. (1976). Thrombos. Haemostas., 36, 388–391.

    CAS  Google Scholar 

  30. Haslam, R.J. and Cusack, N.J. (1981). In Purinergic Receptors: Receptors and Recognition Series B Volume 12. (ed. G. Burnstock). Chapman and Hall, London.

    Google Scholar 

  31. Haslam, R.J., Davidson, M.M.L. and Desjardins, J.V. (1978). Biochem. J., 176, 83–95.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  32. Haslam, R.J. and Rosson, G.M. (1975). Mol. Pharmacol., 11, 528–544.

    PubMed  CAS  Google Scholar 

  33. Haslam, R.J., Salama, S.E., Fox, J.E.B., Lynham, J.A. and Davidson, M.M.L. (1980). In Platelets: Cellular Response Mechanisms and their Biological Significance. (eds. A. Rotman, F.A. Meyer, C. Gitler, and A. Silberberg). Wiley, Chichester.

    Google Scholar 

  34. Haslam, R.J. and Taylor, A. (1971). In Platelet Aggregation. (ed. J. Caen). Masson, Paris.

    Google Scholar 

  35. Hourani, S.M.O. (1982). Ph. D. Thesis, London University.

    Google Scholar 

  36. Hourani, S.M.O. (1984). Br. J. Pharmacol., 82, 161–164.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  37. Hiitteman, E., Ukena, D., Lenschow, V. and Schwabe, U. (1984). Naunyn-Schmied. Arch. Pharmacol., 325, 226–233.

    Google Scholar 

  38. Jakobs, K.H., Saur, W. and Johnson, R.A. (1979). Biochim. Biophys. Acta. 583. 409–421.

    Google Scholar 

  39. Kikugawa, K., Iizuka, K., Higuchi, Y., Hirayama, H. and Ichino, M. (1972). J. Med. Chem., 15, 387–390.

    Google Scholar 

  40. Kikugawa, K., Iizuka, K. and Ichino, M. (1973). J. Med. Chem., 16, 358–364.

    Google Scholar 

  41. Londos, C., Cooper, D.M.F. and Wolff, J. (1980). Proc. Natl. Acad. Sci. USA, 77, 2551–2554.

    Google Scholar 

  42. Londos, C. and Wolff, J. (1977). Proc. Natl. Acad. Sci. USA, 74, 5482–5486.

    Google Scholar 

  43. Lukacsko, P. and Krell, R.D. (1982). Eur. J. Pharmacol., 80, 401–406.

    Article  PubMed  CAS  Google Scholar 

  44. Llischer, E.F., Massini, P. and KUser-Glanzmann, R. (1980). In Platelets: Cellular Response Mechanisms and their Biological Significance. (eds. A. Rotman, F.A. Meyer, C. Gitler and A. Silberberg). Wiley, Chichester.

    Google Scholar 

  45. Macfarlane, D.E. and Mills, D.C.B. (1975). Blood, 46, 309–320.

    PubMed  CAS  Google Scholar 

  46. Macfarlane, D.E., Mills, D.C.B. and Srivastava, P.C. (1982). Biochemistry, 21, 544–549.

    Article  PubMed  CAS  Google Scholar 

  47. Macfarlane, D.E., Srivastava, P.C. and Mills, D.C.B. (1983). J. Clin. Invest., 71, 420–428.

    Google Scholar 

  48. Maguire, M.H. (1981). Proc. West. Pharmacol. Soc., 24, 381–384.

    Google Scholar 

  49. Maguire, M.H. and Satchell, D.G. (1981). In Purinergic Receptors: Receptors and Recognition Series B Volume 12. (ed. G. Burnstock). Chapman and Hall, London.

    Google Scholar 

  50. Mills, D.C.B., Macfarlane, D.E., Lemmex, B.W.G. and Haslam, R.J. (1983). In Regulatory Function of Adenosine. (eds. R.M. Berne, T.W. Rall and R. Rubio). Martinus Nijhoff, The Hague.

    Google Scholar 

  51. Mills, D.C.B. and Smith, J.B. (1971). Biochem. J., 121, 185–196.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  52. Packham, M.A., Guccione, M.A., Perry, D.W., Kinlough-Rathbone, R.L. and Mustard, J.F. (1972). Am. J. Physiol., 223, 419–424.

    Article  PubMed  CAS  Google Scholar 

  53. Pearce, P.H., Wright, J.M., Egan, C.M. and Scrutton, M.C. (1978). Eur. J. Biochem., 88, 543–554.

    Article  PubMed  CAS  Google Scholar 

  54. Ragatz, B.H., Iatridis, P.G., Iatridis, S.G., Markidou, S.G., Asterita, M.F. and Gadarowski, J. (1977). Thrombos. Haemostas., 38, 209.

    Google Scholar 

  55. Robey, F.A., Jamieson, G.A. and Hunt, J.B. (1979). J. Biol. Chem., 254, 1114–1118.

    Google Scholar 

  56. Salzman, E.W. (1972). N. Eng. J. Med., 286, 358–363.

    Google Scholar 

  57. Salzman, E.W., Maclntyre, D.E., Steer, M.L. and Gordon, J.L. (1978). Thrombos. Res., 13, 1089–1101.

    Article  CAS  Google Scholar 

  58. Sixma, J.L., Lips, J.P.M., Trieschnigg, A.M.C.-and Holmsen, H. (1976). Biochim. Biophys. Acta, 443, 33–48.

    Google Scholar 

  59. Stein, H.H., Somani, P. and Prasad, R.N. (1975). Ann. N. Y. Acad. Sci., 255, 380–389.

    Google Scholar 

  60. Stone, J.V., Singh, R.K., HorAk, H. and Barton, P.G. (1976). Can. J. Biochem.. 54. 529–533.

    Article  PubMed  CAS  Google Scholar 

  61. Van Calker, D., Miiller, M. and Hamprecht, B. (1979). J. Neurochem., 33, 999–1005.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. S. M. O. Hourani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. J. Cusack
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, St George’s Hospital Medical School, SW17 0RE, London, UK

    T. W. Stone

Copyright information

© 1985 The Contributors

About this chapter

Cite this chapter

Hourani, S.M.O., Cusack, N.J. (1985). Actions and Structure-Activity Relationships of Purines on Platelets. In: Stone, T.W. (eds) Purines. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07564-5_17

Download citation

Publish with us

Policies and ethics

Search

Navigation