Abstract
Adenosine is a well known dilator of resistance vessels and probably plays an important role in the local regulation of blood flow. In the heart, administered adenosine increases coronary blood flow, and a reduction in oxygen supply or an increase in oxygen demand results in the release of adenosine and a decrease in coronary vascular resistance (Berne, 1980; Berne and Rubio, 1979). Similar observations have been made to different degrees in brain (Berne et al., 1981; Berne et al., 1983), skeletal muscle (Berne et al., 1983; Steffen et al., 1983), adipose tissue (Sollevi and Fredholm, 1981), and intestine (Granger and Norris, 1980). In the kidney adenosine produces vasoconstriction which is probably mediated via the renin-angiotensin system (Oswald, 1983), but isolated renal artery strips relax when exposed to adenosine. Finally, closure of the ductus arteriosus at birth is associated with a significant reduction in the circulating blood levels of adenosine (Mentzer et al., 1983).
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Berne, R.M. (1985). Adenosine and the Cardiovascular System: Some of the Problems and Controversies. In: Stone, T.W. (eds) Purines. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07564-5_13
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DOI: https://doi.org/10.1007/978-1-349-07564-5_13
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