Abstract
It is now well established that the common targets for antipsychotic drugs are constituted by dopamine (DA) receptors in CNS, among which several pharmacological classes can be distinguished. The D-1 and D-2 receptors were initially defined using more or less discriminant agonists and antagonists on two different DA responses e.g. the stimulation of adenylate cyclase namely in the striatum and the inhibition of prolactin release by mammotrophs of the anterior pituitary, respectively (Kebabian and Calne, 1979; Kebabian and Cote, 1981).
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Protais, P. et al. (1986). Dopaminergic Behavioral Responses and Classes of Binding Sites Distinguished by Discriminant Benzamide Derivatives. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_9
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