Abstract
Evidence for the compartmentation of DA catabolism in rodents has been obtained by pharmacological experiments. Impairment of intraneuronal DA storage with reserpine increases DOPAC concentration before HVA, indicating intraneuronal formation of DOPAC (Guldberg & Broch, 1971). Westerink & Spaan (1982) determined the release of DA in push pull perfusates from rat striatum. From their results,it can be concluded that catabolism of DA to DOPAC and HVA reflects the synthesis rate of DA and that the metabolic route to 3-methoxytyramine and HVA reflects the release of the amine.
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References
GULDBERG, H.C. & BROCH, O.J. Jr. (1971). On the mode of action of reserpine on dopamine metabolism in the rat striatum. Eur. J. Pharmac, 13, 155–167.
WESTERINK, B.H.C. & SPAAN S.J. (1982). Estimation of the Turnover of 3-MT in the Rat Striatum by HPLC with Electrochemical Detection. J. Neurochem. 38, 342–347.
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Ebinger, G., Deleu, D., Michotte, Y. (1986). Distribution of DOPAC and HVA in Human Brain Using Capillary GC and GC-MS. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_76
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DOI: https://doi.org/10.1007/978-1-349-07431-0_76
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