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Distribution of DOPAC and HVA in Human Brain Using Capillary GC and GC-MS

  • G. Ebinger
  • D. Deleu
  • Y. Michotte
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

Evidence for the compartmentation of DA catabolism in rodents has been obtained by pharmacological experiments. Impairment of intraneuronal DA storage with reserpine increases DOPAC concentration before HVA, indicating intraneuronal formation of DOPAC (Guldberg & Broch, 1971). Westerink & Spaan (1982) determined the release of DA in push pull perfusates from rat striatum. From their results,it can be concluded that catabolism of DA to DOPAC and HVA reflects the synthesis rate of DA and that the metabolic route to 3-methoxytyramine and HVA reflects the release of the amine.

Keywords

Synthesis Rate Pharmacological Experiment Dopaminergic Neurotransmission Metabolic Route Sample Brain Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. GULDBERG, H.C. & BROCH, O.J. Jr. (1971). On the mode of action of reserpine on dopamine metabolism in the rat striatum. Eur. J. Pharmac, 13, 155–167.CrossRefGoogle Scholar
  2. WESTERINK, B.H.C. & SPAAN S.J. (1982). Estimation of the Turnover of 3-MT in the Rat Striatum by HPLC with Electrochemical Detection. J. Neurochem. 38, 342–347.PubMedCrossRefGoogle Scholar

Copyright information

© The Contributors 1986

Authors and Affiliations

  • G. Ebinger
    • 1
  • D. Deleu
    • 1
  • Y. Michotte
    • 1
  1. 1.Department of Neurology, Academic Hospital Laboratory for Analytical Chemistry, Pharmaceutical InstituteVrije Universiteit Brussel-Laarbeeklaan 101BrusselsBelgium

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