Distribution of DOPAC and HVA in Human Brain Using Capillary GC and GC-MS
Evidence for the compartmentation of DA catabolism in rodents has been obtained by pharmacological experiments. Impairment of intraneuronal DA storage with reserpine increases DOPAC concentration before HVA, indicating intraneuronal formation of DOPAC (Guldberg & Broch, 1971). Westerink & Spaan (1982) determined the release of DA in push pull perfusates from rat striatum. From their results,it can be concluded that catabolism of DA to DOPAC and HVA reflects the synthesis rate of DA and that the metabolic route to 3-methoxytyramine and HVA reflects the release of the amine.