Regulation of the Synaptosomal Tyrosine Hydroxylase Activity via Presynaptic Receptors in the Nucleus Accumbens of Rats

  • L. Hetey
  • V. S. Kudrin
  • K. S. Rayevsky
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

There is increasing evidence for the existence of presynaptic dopamine (DA)-autoreceptors as well as serotonin (5HT)-heteroreceptors modulating the DA release in the striatum (Ennis et al., 1981) and the nc. accumbens of rats (Hetey et al., 1982). On the other hand, there exist contradictory experimental data about the control of tyrosine hydroxylase (TH) activity via autoreceptors. Especially the role of DA is questionable because of its direct inhibition of the enzyme. Furthermore, a direct comparison of receptors modulating TH as well as DA release is not possible, since the methodic approaches are too different. Therefore we investigated the modulation of the synaptosomal TH activity under the same conditions as we used for DA release studies in the nc. accumbens (in 30 mM K+-buffer, at inhibition of the amine uptake; see Hetey et al., 1983).

Keywords

Dopamine Tyrosine Serotonin Haloperidol Clozapine 

References

  1. Ennis, C., Kemp, J.D. and Cox, B. (1981). Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J. Neurochem., 36, 1515–1520.PubMedCrossRefGoogle Scholar
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  3. Hetey, L., Schwitzkowsky, R. and Oelssner, W. (1983). Influence of psychotomimetics and lisuride on synaptosomal dopamine release in the nucleus accumbens of rats. European J. Pharmacol. 93, 213–220.CrossRefGoogle Scholar

Copyright information

© The Contributors 1986

Authors and Affiliations

  • L. Hetey
    • 1
  • V. S. Kudrin
    • 1
  • K. S. Rayevsky
    • 2
  1. 1.Institute of Pharmacology and Toxicology of CharitéHumboldt UniversityGermany
  2. 2.Institute of PharmacologyUSSR Academy of Medical SciencesMoscowUSA

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