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Parkinsonism Induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Marmoset: Effects of Bromocriptine and L-Dopa

  • S. P. Close
  • A. S. Marriott
  • S. Pay
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) appears to have a specific neurotoxic effect upon nigro-striatal neurones in human and Rhesus monkey (Burns et al., 1983; Langston et al., 1983). This lesion gives rise to a parkinsonian syndrome that can be reversed by L-DOPA. We report that MPTP produces a similar but temporary syndrome in the marmoset that can be relieved by bromocriptine and L-DOPA.

Keywords

MPTP Treatment MPTP Injection Limb Tremor Dopa Decarboxylase Inhibitor Coarse Tremor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J. (1983). A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A., 80, 4546–4550. PubMedPubMedCentralCrossRefGoogle Scholar
  2. Langston, J.W., Ballard, P., Tetrud, J.W. and Irwin, I. (1983). Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis. Science, 219, 979–980.PubMedCrossRefGoogle Scholar

Copyright information

© The Contributors 1986

Authors and Affiliations

  • S. P. Close
    • 1
  • A. S. Marriott
    • 1
  • S. Pay
    • 1
  1. 1.Department of NeuropharmacologyGlaxo Group Research LtdWareUK

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