Abstract
Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) appears to have a specific neurotoxic effect upon nigro-striatal neurones in human and Rhesus monkey (Burns et al., 1983; Langston et al., 1983). This lesion gives rise to a parkinsonian syndrome that can be reversed by L-DOPA. We report that MPTP produces a similar but temporary syndrome in the marmoset that can be relieved by bromocriptine and L-DOPA.
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Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J. (1983). A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A., 80, 4546–4550.
Langston, J.W., Ballard, P., Tetrud, J.W. and Irwin, I. (1983). Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis. Science, 219, 979–980.
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Close, S.P., Marriott, A.S., Pay, S. (1986). Parkinsonism Induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Marmoset: Effects of Bromocriptine and L-Dopa. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_56
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DOI: https://doi.org/10.1007/978-1-349-07431-0_56
Publisher Name: Palgrave Macmillan, London
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