Parkinsonism Induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Marmoset: Effects of Bromocriptine and L-Dopa
Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) appears to have a specific neurotoxic effect upon nigro-striatal neurones in human and Rhesus monkey (Burns et al., 1983; Langston et al., 1983). This lesion gives rise to a parkinsonian syndrome that can be reversed by L-DOPA. We report that MPTP produces a similar but temporary syndrome in the marmoset that can be relieved by bromocriptine and L-DOPA.
KeywordsMPTP Dopa Bromocriptine Mesylate Meperidine
- Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J. (1983). A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A., 80, 4546–4550. PubMedPubMedCentralCrossRefGoogle Scholar