Abstract
Following the discovery of dopamine autoreceptors in the early 1970’s, a concerted effort has been made by many groups to learn more about the pharmacology, physiology, distribution and function of this interesting class of dopamine receptors. The major focus of these studies, until recently, has been on autoreceptors present on the nigrostriatal and mesolimbic dopamine neurons. Dopamine autoreceptors on nerve terminals and soma/dendrites of these neuronal systems are thought to constitute an important autoregulatory mechanism influencing both the physiological activity and the pharmacological responsiveness of dopamine-containing neurons. The properties of dopamine autoreceptors, determined using both in vivo and in vitro biochemical and in vivo electro-physiological methods, are summarized in Table I. Perhaps the most provocative of these findings were the observations that dopamine autoreceptors differ from typical postsynaptic dopamine receptors in their pharmacological profile (Carlsson and Nilsson, 1983; Andén et al., 1984).
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Roth, R.H., Galloway, M.P., Tam, S.Y., Ono, N., Wolf, M.E. (1986). Dopamine Autoreceptors: Studies on their Distribution and Mode of Action. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_4
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