Abstract
Haloperidol (HAL) blocks dopamine (CA) receptors. This activity at pituitary DA receptors elicits an elevation in prolactin (PRL) secretion and synthesis, while at striatal DA receptors after long-term administration it produces an increased density. These two actions had been assumed to be unrelated.
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References
Hruska, R.E. and Pitman, K.T. (1982). Hypophysectomy reduces the haloperidol-induced changes in striatal dopamine receptor density. Eur. J. Pharmacol., 85, 201–205.
Rupniak, N., Hong, M., Mansfield, S., Fleminger, S., Dyer, R., Jenner, P., and Marsden, C.D. (1983). Elevation of circulating prolactin concentrations may not cause striatal dopamine receptor supersensitivity. Eur. J. Pharmacol., 93, 195–200.
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Hruska, R.E. (1986). Modulatory Role of Prolactin in the Development of an Elevated Density of Striatal Dopamine Receptors after the Chronic Administration of Domperidone or Sulpiride. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_47
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DOI: https://doi.org/10.1007/978-1-349-07431-0_47
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