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Dopaminergic Systems and their Regulation pp 45–61Cite as

Palgrave Macmillan

Dopamine Autoreceptors: Studies on their Distribution and Mode of Action

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Abstract

Following the discovery of dopamine autoreceptors in the early 1970’s, a concerted effort has been made by many groups to learn more about the pharmacology, physiology, distribution and function of this interesting class of dopamine receptors. The major focus of these studies, until recently, has been on autoreceptors present on the nigrostriatal and mesolimbic dopamine neurons. Dopamine autoreceptors on nerve terminals and soma/dendrites of these neuronal systems are thought to constitute an important autoregulatory mechanism influencing both the physiological activity and the pharmacological responsiveness of dopamine-containing neurons. The properties of dopamine autoreceptors, determined using both in vivo and in vitro biochemical and in vivo electro-physiological methods, are summarized in Table I. Perhaps the most provocative of these findings were the observations that dopamine autoreceptors differ from typical postsynaptic dopamine receptors in their pharmacological profile (Carlsson and Nilsson, 1983; Andén et al., 1984).

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References

  • Aghajanian, G. K. and Bunney, B. S. (1973). Central dopaminergic neurons: Neurophysiological identification and responses to drugs. In Frontiers of Catecholamine Research. (eds. S. Snyder and E. Usdin). Pergamon Press, New York.

    Google Scholar 

  • Aghajanian, G. K. and Bunney, B. S. (1977). Dopamine “autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedebergs Arch. Pharmacol. 297, 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Andén, N. -E., Alander, T., Grabowska-Andén, M., Liljenberg, B., Lindgren, S. and Thornstrom, U. (1984). The pharmacology of pre- and postsynaptic dopamine receptors: Differential effects of dopamine receptor agonists and antagonists. In Catecholamines: Neuropharmacology and central nervous system. Theroretical Aspects Liss, New York.

    Google Scholar 

  • Bannon, M. J., Bunney, E. B. and Roth, R. H. (1981). Mesocortical dopamine neurons: Rapid transmitter turnover compared to other brain catecholamine systems. Brain Res. 218, 376–382.

    PubMed  CAS  Google Scholar 

  • Bannon, M. J., Michaud, R. L. and Roth, R. H. (1981). Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis. Molec. Pharmacol. 19, 270–275.

    CAS  Google Scholar 

  • Bannon, M. J. and Roth, R. H. (1983). Pharmacology of mesocortical dopamine neurons. Pharmacol. Rev. 35, 53–68.

    PubMed  CAS  Google Scholar 

  • Bannon, M. J., Wolf, M. E. and Roth, R. H. (1983). Pharmacology of dopamine neurons innervating the prefrontal, cingulate and piriform cortices. Eur. J. Pharmacol. 92, 119–125.

    Article  PubMed  CAS  Google Scholar 

  • Bannon, M. J., Reinhard, J. F., Jr., Bunney, E. B. and Roth, R. H. (1982). Unique response to antipsychotic drugs explained by the absence of terminal autoreceptors. Nature 296, 444–446.

    Article  PubMed  CAS  Google Scholar 

  • Billingsley, M. L. and Roth, R. H. (1982). Dopamine autoreceptor agonists stimulate protein carboxylmethylation in striatal synaptosomes. J. Pharmacol. Exp. Ther. 223, 681–688.

    PubMed  CAS  Google Scholar 

  • Billingsley, M. L., Velletri, P. A., Kuhn, D. M., Levine, R. A. and Lovenberg, W. (1983a). Effects of protein carboxylmethylation on (P)-8-azido-ATP binding in rat brain. Soc. Neurosci. Abstr. 9, 596.

    Google Scholar 

  • Billingsley, M. L., Velletri, P. A., Roth, R. H. and DeLorenzo, R. J. (1983b). Carboxylmethylation of calmodulin inhibits calmodulin-dependent phosphorylation in rat brain membranes and cytosol. J. Biol. Chem. 258, 5352–5357.

    PubMed  CAS  Google Scholar 

  • Billingsley, M. L., Kuhn, D., Velletri, P. A., Kincaid, R. and Lovenberg, W. (1984a). Carboxylmethylation of phosphodiesterase attenuates its activation of Ca++-calmodulin. J. Biol. them., in press.

    Google Scholar 

  • Billingsley, M. L., Galloway, M. P. and Roth, R. H. (1984b). Possible role of protein carboxylmethylation in the autoreceptor mediated regulation of dopamine neurons. In Catecholamines: Neuropharmacology and Centrol Nervous System. Theoretical Aspects, Liss, New York.

    Google Scholar 

  • Carlsson, A. and Nilsson, J. L. G. (1983). Dopamine receptor agonists 1. In Proceedings of the Swedish Academy of Pharaceutical Sciences Symposium, Swedish Pharmaceutical Press, Stockholm.

    Google Scholar 

  • Chiodo, L. A., Bannon, M. J., Grace, A. A., Roth, R. H. and Bunney, B. S. (1984). Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neurosci. 12, 1–16.

    Article  CAS  Google Scholar 

  • Chiodo, L. A. and Bunney, B. S. (1983a). Typical and atypical neuroleptics: Differential effects of chronic administration on the activity of A9 and A10 midbrain dopaninergic neurons. J. Neurosci. 3, 1607–1619.

    PubMed  CAS  Google Scholar 

  • Chiodo, L. A. and Bunney, B. S. (1983b). Electrophysiological studies on EMD 23 448: A putative selective dopamine autoreceptor agonist. Neuropharmacol. 22, 1087–1093.

    Article  CAS  Google Scholar 

  • Cubeddu, L. X., Hoffmann, I. S. and James, M. K. (1983). Frequency-dependent effects of neuronal uptake inhibitors on the autoreceptor-mediated modulation of dopamine and acetylcholine release fran the rabbit striatum. J. Pharmacol. 226, 88–94.

    CAS  Google Scholar 

  • Fadda, F., Gessa, G. L., Marcou, M., Mosca, E. and Rossetti, Z. (1984). Evidence for dopamine autoreceptors in mesocortical dopamine neurons. Brain Res. 293, 67–72.

    Article  PubMed  CAS  Google Scholar 

  • Farnebo, L. O. and Hamberger, B. (1971). Drug-induced changes in the release of H3-monoamines from field-stimulated rat brain slices. Acta Physiol. Scand. (Suppl.) 371, 35–44.

    Article  CAS  Google Scholar 

  • Gagnon, C. (1983). Enzymatic carboxyl methylation of calcium-binding proteins. Can. J. Biochem. Cell Biol. 61, 921–926.

    Article  PubMed  CAS  Google Scholar 

  • Gagnon, C., Kelly, S., Manganiello, V., Vaughn, M., Odya, C., Strittmatter, W., Hoffman, A. and Hirata, F. (1981). Modification of calmodulin fuction by enzymatic carboxyl methylation. Nature (London) 291, 515–516.

    Article  CAS  Google Scholar 

  • Galloway, M. P. and Roth, R. H. (1983). Biochemical response of dopamine neurons to atypical neuroleptics is not dependent on autoreceptors. Proc. Soc. Neurosci. 9, 1003 #291.18.

    Google Scholar 

  • Galloway, M. P. and Roth, R. H. (1984). Mesocortical dopamine neuorns: Do agonists inhibit synthesis via a feedback loop or release modulating autoreceptors. Proc. Soc. Neurosci., in press.

    Google Scholar 

  • Herman, J. P., Chillionneau, D., Dantzer, R., Scatton, B., Semerdjian-Rouquier, L. and Lemoal, M. (1982). Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat. Life Sci. 30, 2207–2214.

    Article  PubMed  CAS  Google Scholar 

  • H8kfelt, T., Fuxe, K., Johansson, O. and Lyngahl, A. (1974). Pharmaco-histochemical evidence of the existence of dopamine nerve terminals in the limbic cortex. Eur. J. Pharmacol. 25, 108–112.

    Article  PubMed  Google Scholar 

  • Lindvall, O., Bjorklund, A. and Divac, I. (1978). Organization of catecholamine neurons projecting to the frontal cortex in the rat. Brain Res. 142, 1–24.

    Article  PubMed  CAS  Google Scholar 

  • Nowycky, M. D. and Roth, R. H. (1978). Dopaminergic neurons: Role of presynaptic receptors in the regulation of transmitter biosynthesis. Prog. Neuro-Psychopharmac. 2, 139–158.

    Article  CAS  Google Scholar 

  • Roth, R. H. (1984). Dopamine autoreceptors: Distribution, pharmacology and function. Ann. New York Acad. Sci. 430, 27–53.

    Article  CAS  Google Scholar 

  • Roth, R. H. (1979). Dopamine autoreceptors: Pharmacology, function and comparison with postsynaptic dopamine receptors. Commun. Psychopharmac. 3, 429–445.

    CAS  Google Scholar 

  • Roth, R. H., Walters, J. R., Murrin, L. C. and Morgenroth, V. H., III. (1975). Dopaminergic neurons: Role of impulse flow and pre-synaptic receptors in the regulation of tyrosine hydroxylase. In Pre- and Postsynaptic Receptors. (eds. E. Usdin and W. E. Bunney). Dekker, New York.

    Google Scholar 

  • Scatton, B. (1977). Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration. Eur. J. Pharmacol. 46, 363–369.

    Article  PubMed  CAS  Google Scholar 

  • Scatton, B., Glowinski, J. and Julou, L. (1976). Dopamine metabolism in the mesolimbic and mesocortical dopaminergic systems after single or repeated administration of neuroleptics. Brain Res. 109, 184–189.

    Article  PubMed  CAS  Google Scholar 

  • Skirboll, L. R., Grace, A. A. and Bunney, B. S. (1979). Dopamine auto- and postsynaptic receptors. Electrophysiological evidence for differential sensitivity to dopamine agonists. Science, N.Y. 206, 80–82.

    Article  CAS  Google Scholar 

  • Starke, K., Reimann, W., Zumstein, A. and Herting, G. (1978). Effect of dopamine receptor agonists and antagonists on release of dopamine in the rat caudate nucleus in vitro. Nauyn-Schmiedebegs Arch. Pharmacol. 305, 27–36.

    Article  CAS  Google Scholar 

  • Swanson, L. W. (1982). The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde and immunofluorescence study in the rat. Brain Res. Bull. 9, 321–353.

    Article  PubMed  CAS  Google Scholar 

  • Tam, S. Y., Bannon, M. J. and Roth, R. H. (1983). Apomorphine selectively reverses the impulse induced increase in dopamine synthesis in mesocortical dopamine neurons with autoreceptors. Proc. Soc. Neurosci. 9, 291.19.

    Google Scholar 

  • Tam, S.-Y. and Roth, R. H. (1984). Tyrosine preferentially increases dopamine synthesis in mesocortical dopamine neurons with high firing frequency. Proc. Soc. Neurosci., in press.

    Google Scholar 

  • Thierry, A. M., Blanc, G., Sobel, A., Stinus, L. and Glowinski, J. (1973). Dopaminergic terminals in the rat cortex. Science, N.Y. 182, 499–501.

    Article  CAS  Google Scholar 

  • Thierry, A. M., Tassin, J. P., Blanc, G. and Glowinski, J. (1976). Selective activation of the mesocortical DA system by stress. Nature 263, 242–243.

    Article  PubMed  CAS  Google Scholar 

  • Thierry, A. M., Tassin, J. P., Blanc, G. and Glowinski, J. (1978). Studies on mesocortical dopamine systems. In Advances in Biochemical Psychopharmacology. (eds. P. J. Roberts, G. N. Woodruff and L. L. Iversen). Raven Press, New York.

    Google Scholar 

  • Walters, J. R. and Roth, R. H. (1976). Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors. Naunyn-Schmiedebergs Arch. Pharmacol. 296, 5–14.

    Article  PubMed  CAS  Google Scholar 

  • White, F. J. and Wang, R. Y. (1983). A10 dopamine neurons: Role of autoreceptors in determining firing rate and sensitivity to dopamine agonists. Life Sci. 34, 1161–1170.

    Article  Google Scholar 

  • Wolf, M. E. and Roth, R. H. (1984a). Inhibition of protein carboxyl methylation blocks modulation by DA agonists of 3H-DA release from brain slices. Proc. Soc. Neurosci., in press.

    Google Scholar 

  • Wolf, M. E. and Roth, R. H. (1984b). Dopamine autoreceptor stimulation increases protein carboxyl methylation in striatal slices. J. Neurochem., in press.

    Google Scholar 

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Authors
  1. R. H. Roth
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  2. M. P. Galloway
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  3. S. -Y. Tam
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  4. N. Ono
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  5. M. E. Wolf
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Editor information

Editors and Affiliations

  1. Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK

    G. N. Woodruff (Director of Pharmacology) (Director of Pharmacology)

  2. Department of Physiology and Pharmacology, University of Southampton, UK

    J. A. Poat  & P. J. Roberts  & 

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© 1986 The Contributors

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Roth, R.H., Galloway, M.P., Tam, S.Y., Ono, N., Wolf, M.E. (1986). Dopamine Autoreceptors: Studies on their Distribution and Mode of Action. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_4

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  • DOI: https://doi.org/10.1007/978-1-349-07431-0_4

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-07433-4

  • Online ISBN: 978-1-349-07431-0

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