Abstract
The double labelling test which evaluates the [3H]- dopa mine (DA) uptake and the [14C]DA release by striatal synaptosomes (Bonnet et al., 1984), revealed that numerous antidepressant drugs inhibit [3H]DA uptake at the same high concentrations that produce [14C]DA release (Lemasson et al., 1984). Therefore, we suggested that the inhibition of DA uptake was artefactual and could represent the releasing effect of antidepressants, which induced the release of [3H]DA as fast as its uptake by synaptosomes.
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Bonnet, J.-J., Lemasson, M.-H., and J. Costentin (1984). Biochem. Pharmac. 33, 2129–2135.
Lemasson, M.-H., Bonnet, J.-J., and J. Costentin (1984). Biochen. Pharmac. 33, 2137–2141.
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Bonnet, J.J., Dubuc, I., Costentin, J. (1986). Effects of Antidepressant Drugs on [3H]Dopamine Uptake and Storage by Rat Striatal Vesicles. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_39
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DOI: https://doi.org/10.1007/978-1-349-07431-0_39
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