Abstract
CNS stimulants and some antidepressants are known to activate central DA-ergic transmission, by inhibition of the uptake of DA or by its release from nerve terminals. These effects are well-documented. Surprisingly, they is only sparse information on the effect of these classes of drugs on DA receptors. Recently, we have shown that bupropion (BUP), an antidepressant, can modify the affinity of DA receptors after its acute injection to rats (Bischoff et al., 1984) To further characterize the mode of action of CNS stimulants and DA-activating antidepressants, we studied their effects on in vitro and in vivo (3H)spiperone (SPI) binding.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Bischoff S., Bittiger H. and Krauss J. (1980). In vivo (3H)spiperone binding to the rat hippocampal formation: involvement of dopamine receptors. Eur. J. Pharmacol., 68, 305–315.
Bischoff S., Bittiger H., Krauss J.. Vassout A. and Waldmeier P. (1984). Affinity changes of rat striatal dopamine receptors in vivo after acute bupropion treatment. Eur. J. Pharmacol. (in press).
Waldmeier P., Buchle A.-M., Stoecklin K., Fehr B. and Feldtrauer J.-J. (1983). The effects of amfonelic acid on 5-HT metabolism in rat brain. J. Neural Transm., 51, 149–165.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1986 The Contributors
About this chapter
Cite this chapter
Bischoff, S., Vassout, A., Waldmeier, P., Bittiger, H. (1986). In vivo Regulation of Brain Dopamine (DA) Receptors by Antidepressants and CNS Stimulants. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_37
Download citation
DOI: https://doi.org/10.1007/978-1-349-07431-0_37
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-07433-4
Online ISBN: 978-1-349-07431-0
eBook Packages: MedicineMedicine (R0)