Abstract
The benzazepine derivative SCH 23390[(R)−(+)−8−chloro−2,3,4,5-tetrahydro− 3−methyl−5−phenyl−1H−3−benzazepine] has recently been shown to antagonise dopamine-stimulated adenylate cyclase activity in homogenates of rat striatum at concentrations (IC50 = 0.01μM) approximately 2000 times lower than those required to displace 3H-spiperone binding (Iorio et al, 1983). These data have led to the suggestion that SCH 23390 is a selective D1 receptor antagonist. To examine further the pharmacological specificity of this compound, we have investigated the effects of SCH 23390 on other central neurotransmitter- stimulated adenylate cyclase systems.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References:
Dowling, J.E. and Watling, K.J.(1981). Dopaminergic mechanisms in the teleost retina. II. Factors affecting the accumulation of cyclic AMP in pieces of intact carp retina. J. Neurochem, 36, 569–579.
Iorio, L.C., Barnett, A., Leitz, F.H., Houser, V.P. and Korduba, C.A (1983). SCH 23390, A potential benzazepine antipsychotic with unique interactions on dopaminergic systems. J. Pharmacol. Exp. Therap. 226, 462–468.
Watling, K.J. and Dowling, J.E. (1981). Dopaminergic mechanisms in the teleost retina. I. Dopamine-sensitive adenylate cyclase in homogenates of carp retina; effects of agonists, antagonists and ergots. J. Neurochem 36, 559–568.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1986 The Contributors
About this chapter
Cite this chapter
Watling, K.J., Williams, L.C., Bristow, D.R. (1986). Effects of SCH 23390 on Neurotransmitter-stimulated Cyclic AMP Accumulation in Mammalian Brain and Teleost Retina. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_33
Download citation
DOI: https://doi.org/10.1007/978-1-349-07431-0_33
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-07433-4
Online ISBN: 978-1-349-07431-0
eBook Packages: MedicineMedicine (R0)