Down-regulation of Dopamine Autoreceptors by Estrogens: Physiological Control

  • M. P. Piccardi
  • G. Martis
  • S. Mulas
  • G. U. Corsini
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)


Many studies have demonstrated an effect of estrogenic compounds on central dopaminergic activity. Some clinical observations have shown that both an increase of endogenous estrogens, as observed during pregnancy, and the oral administration of synthetic estrogenic compounds, as during oral contraceptive treatment, may induce extrapyramidal disorders. Choreatic movements have been described during oral contraception by several authors (3,16,19, 28, 32, 36) and in 1978 Donaldson (14) reviewed the cases of abnormal movements associated with pregnancy. Moreover, it has been reported that estrogen treatment improves L-DOPA induced dyskinesias in parkinsonian patients (6,7), worsens the neuroleptic-induced parkinsonian syndrome (22) and markedly ameliorates tardive dyskinesia (6, 7, 43, 44).


High Performance Liquid Chromatography Estrous Cycle Tardive Dyskinesia Estrogen Treatment Endogenous Estrogen 
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© The Contributors 1986

Authors and Affiliations

  • M. P. Piccardi
  • G. Martis
  • S. Mulas
  • G. U. Corsini

There are no affiliations available

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