Skip to main content
SpringerLink
Log in

Down-regulation of Dopamine Autoreceptors by Estrogens: Physiological Control

  • Chapter
Dopaminergic Systems and their Regulation

  • 187 Accesses

Abstract

Many studies have demonstrated an effect of estrogenic compounds on central dopaminergic activity. Some clinical observations have shown that both an increase of endogenous estrogens, as observed during pregnancy, and the oral administration of synthetic estrogenic compounds, as during oral contraceptive treatment, may induce extrapyramidal disorders. Choreatic movements have been described during oral contraception by several authors (3,16,19, 28, 32, 36) and in 1978 Donaldson (14) reviewed the cases of abnormal movements associated with pregnancy. Moreover, it has been reported that estrogen treatment improves L-DOPA induced dyskinesias in parkinsonian patients (6,7), worsens the neuroleptic-induced parkinsonian syndrome (22) and markedly ameliorates tardive dyskinesia (6, 7, 43, 44).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abraham G.E., Manlimos F.S., Garza R. (1977): Radioimmunoassay of steroids. In: Handbook of radioimmunoassay, eds. G.E.Abraham, M. Dekker Inc., New York, U.S.A., pp.590.

    Google Scholar 

  2. Ball P., Knuppen R., Haupt M. and Breur H. (1972): Interactions between estrogens and catecholamines: Studies on the methylation of catechol estrogens, catecholamines and other catechols by catechol-o-methyltransferase of human liver. J.Clin.Endocrinol. Metab. 34, 736 – 746.

    Article  PubMed  CAS  Google Scholar 

  3. Barber P.V., Arnold A.G. and Evans G. (1976): Recurrent hormone dependent chorea: effects of estrogens and progestogens. Clin. Endocrinol. 5, 291 – 293.

    Article  CAS  Google Scholar 

  4. Beatty W.W. and Holzer G.A. (1978): Sex differences in stereotyped behaviour in the rat. Pharmacol.Biochem.Behav. 9, 777 – 783.

    Article  PubMed  CAS  Google Scholar 

  5. Bedard P., Dankova J., Boucher R. and Langelier P. (1978): Effect of estrogens on apomorphine-induced circling behaviour in the rat. Can.J.Physiol.Pharmacol. 56, 538 – 541.

    Article  PubMed  CAS  Google Scholar 

  6. Bedard P., Langelier P., Dankova J., Villeneuve A., Di Paolo T., Barden N., Labrie F., Boissier J.R. and Euvrard C. (1979): Estrogens, progesterone and the extrapyramidal system. In: Extrapyramidal system and its disorders, eds: L.J.Poirier, T.L.Sourkes and P.Bedard, Raven Press, New York, pp.411 – 422.

    Google Scholar 

  7. Bedard P., Langelier P. and Villenenuve A. (1977): Estrogens and extrapyramidal system. Lancet 2, 1367 – 1368.

    Article  PubMed  CAS  Google Scholar 

  8. Carlsson A. (1975): Receptor-mediated control of dopamine metabolism. In: Pre-and Post-synaptic receptors, eds.E.Usdin and W.E. Bunney Jr., Marcel Dekker, New York, pp.49 – 65.

    Google Scholar 

  9. Chiodo L.A. and Antelman S.M. (1980b): Repeated tricyclics induce a progressive dopmaine autoreceptor subsensitivity independent of daily drug treatment. Nature 287, 451 – 454.

    Article  PubMed  CAS  Google Scholar 

  10. Chiodo L.A. and Caggiula A.R. (1980a): Alterations in basal firing rate and autoreceptor sensitivity of dopamine neurons in the substantia nigra following acute and extended exposure to estrogen. Eur.J.Pharmacol. 67, 165 – 166.

    Article  PubMed  CAS  Google Scholar 

  11. Chiodo L.A., Caggiula A.R. and Saller C.F. (1980c): Estrogen potentiates the stereotypy induced by dopamine agonists in the rat. Life Sci. 28, 82è – 835.

    Google Scholar 

  12. Conney A.H. (1971): Environmental factors influencing drug metabolism. In: Fundamentals of drug metabolism and drug dispersion, eds. B.M.La Der, H.G.Mandel and E.L.Way, Williams and Williams, Baltimore, pp.253 – 278.

    Google Scholar 

  13. Coppen A. and Kessel N. (1983): Menstruation and personality, Br. J.Psychiatry 109, 711 – 721.

    Article  Google Scholar 

  14. Donaldson J.O. (1978): In: Neurology of Pregnancy, W.B.Saunders Co., Philadelphia, pp.74 – 87.

    Google Scholar 

  15. Euvrard C., Oberlander C. and Boissier J.R. (1980): Antidopaminergic effect of estrogens at the striatal level. J.Pharmacol. Exp.Ther. 214, 179 – 185.

    PubMed  CAS  Google Scholar 

  16. Fernando S.J.M. (1966): An attack of chorea complicating oral contraceptive therapy. Practitioner 197, 210 – 211.

    PubMed  CAS  Google Scholar 

  17. Fields J.Z., Callahan M.F. and Gordon J.H. (1980): Effect of estrogens on the development and expression of dopamine receptor supersensitivity. Abs.Soc.NeuroSci. 6, 255.

    Google Scholar 

  18. Flemenbaum A. (1979): Rat dopaminergic hypersensitivity. II, Effects of sex. Neuropsychobiology 2, 222.

    Article  Google Scholar 

  19. Gamboa E.T., Isaacs G. and Harter D. (1971): Chorea associated with oral contraceptive therapy. Arch.Neurol. 25, 112 – 114.

    Article  PubMed  CAS  Google Scholar 

  20. Gordon J.H. (1980): Modulation of apomorphine-induced stereotypy by estrogen: time-course and dose-response. Brain Res.Bull. 5, 679 – 682.

    Article  PubMed  CAS  Google Scholar 

  21. Gordon J.H., Gorski R.A., Borison R.L. and Diamond B.I. (1980): Postsynaptic efficacy of dopamine: possible suppression by estrogen. Pharmacol.Biochem.Behav. 12, 515 – 518.

    Article  PubMed  CAS  Google Scholar 

  22. Gratton L. (1960): Neuroleptiques, parkinsonisme et schizophrénie. Union Med.Can. 89, 681 – 694.

    Google Scholar 

  23. Hruska R.E., Ludmer L.M. and Silbergeld E.K., 1980. Characterization of the striatal dopamine receptor supersensitivity produced by estrogen treatment of male rats. Neuropharmacology 19, 923 – 926.

    Article  PubMed  CAS  Google Scholar 

  24. Hruska R.E. and Silbergeld E.K. (1980): Estrogen treatment enhan dopamine receptor sensitivity in the rat striatum. Eur.J. Pharmacol. 61, 397 – 400.

    Article  PubMed  CAS  Google Scholar 

  25. Hruska R.E. and Silbergeld E.K. (1980): Increased dopamine recep tor sensitivity after estrogen treatment using the rat striatum rotation model. Science 208, 1466 – 1468.

    Article  PubMed  CAS  Google Scholar 

  26. Koller W.C., Weiner W.J., Klawans H.L. and Nausieda P.A. (1980): Influence of female sex hormones on neuroleptic induced behavioural supersensitivity. Neuropharmacology 19, 387.

    Article  PubMed  CAS  Google Scholar 

  27. Labrie F., Beaulieu H., Raymond D.V., Di Paolo T., Caron M., Veilleux R., Denizeau F., Euvrard C., Raynaud J.P. and Boissier J.R. (1979): Control of prolactin secretion at the pituitary level: a model for postsynaptic dopaminergic systems. In: Effect of hypothalamic hormones and other peptides, eds.R.Collu, Raven Press, New York, pp.207 – 234.

    Google Scholar 

  28. Labrie F., Di Paolo T., Raymond V., Ferland L. and Beaulieu M. (1980): The pituitary dopamine receptor. In: Ergot compounds and brain function: Neuroendocrine and neuropsychiatric aspects, eds. M.Goldstein, D.B.Calne, A.N.Lieberman and M.O.Thorner, Raven Press, New York, pp.217.

    Google Scholar 

  29. Lewis P.D. and Harrison M.J.G. (1969): Involuntary movements in patients taking oral contraceptives. Neurology 29, 1605 – 1609.

    Google Scholar 

  30. Masur J., Boerngen R. and Tufik S. (1980): Sex differences in the response to apomorphine in rats. Pharmacology 20, 160 – 165.

    Article  PubMed  CAS  Google Scholar 

  31. Meyer E. (1977): Age and sex related differences in amphetamine induced locomotor activity. Fed.Proc. 36, 1033.

    Google Scholar 

  32. Mislow J.F. and Friedhoff A.J. (1973): A comparison of chlorpromazine-induced extrapyramidal syndrome in male and female rats. In: Hormones and Brain Function, eds. K.Lissak, Plenum Press, New York, pp. 315 – 326.

    Google Scholar 

  33. Nausieda P.A., Koller W.C., Weiner W.J. and Klawans H.L. (1979): Chorea induced by oral contraceptives. Neurology 29, 1605 – 1609.

    Article  PubMed  CAS  Google Scholar 

  34. Piccardi M.P., Bernardi F., Rossetti Z. and Corsini G.U. (1983): Effect of estrogens on dopamine autoreceptors in male rats. Eur. J.Pharmac. 91, 1 – 9.

    Article  CAS  Google Scholar 

  35. Piccardi M.P., Bernardi F., Bocchetta A. and Corsini G.U. (1983): Estrogen modulation of dopaminomimetic actions: implications for autoreceptor regulation. In: Lisuride and other dopaminomimetics, eds. D.B.Calne et al, Raven Press, New York, pp.55 – 63.

    Google Scholar 

  36. Raymond V., Beaulieu H., Labrie F. and Boissier J.R. (1978): Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release. Science 200, 1173 – 1175.

    Article  PubMed  CAS  Google Scholar 

  37. Riddoch D., Jefferson M. and Bickerstaff E.R. (1971): Chorea and the oral contraceptives. Br.Med.J. 4, 217 – 218.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  38. Robinson T.E., Becker J.B. and Ramirez V.D. (1980): Sex differen ces in amphetamine-elicited rotational behaviour and the lateralization of striatal dopamine in rats. Brain Res.Bull. 5, 539 – 541.

    Article  PubMed  CAS  Google Scholar 

  39. Robinson T.E., Camp D.M. and Becker J.B. (1981): Gonadectomy attenuates turning behaviour produced by electrical stimulation of the nigrostriatal dopamine system in female but not in male rats. NeuroSci Lett. 23, 203 – 208.

    Article  PubMed  CAS  Google Scholar 

  40. Schneider B.F. and Norton S. (1979): Circadian and sex differences in hyperactivity produced by amphetamine in rats. Physiol. Behav. 22, 47 – 51.

    Article  PubMed  CAS  Google Scholar 

  41. Steiner M., Kats R.J. and Carroll B.J. (1980): Behavioural effects of dopamine agonists across the estrous cycle in rats. Psycho-pharmacology 71, 147 – 151.

    Article  CAS  Google Scholar 

  42. Strombom U. (1976): Catecholamine receptor agonists. Effect on motor activity and rate tyrosine hydroxylation in mouse brain. Arch.Pharmacol. 292, 167.

    Article  CAS  Google Scholar 

  43. Villeneuve A., Cazejust T. and Coté M. (1980): Estrogens in tardive dyskinesia in male psychiatric patients. Neuropsychobiology 6, 145 – 151.

    Article  PubMed  CAS  Google Scholar 

  44. Villeneuve A., Langelier P. and Bedard P. (1978): Estrogens, dopamine and dyskinesias. Can.Psychiat.Assoc. 23, 68 – 70.

    CAS  Google Scholar 

  45. Winer B. (1971): In: Statistical Principles in Experimental Design, McGraw Hill, New York.

    Google Scholar 

Download references

Authors
  1. M. P. Piccardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Martis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Mulas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. U. Corsini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK

    G. N. Woodruff (Director of Pharmacology) (Director of Pharmacology)

  2. Department of Physiology and Pharmacology, University of Southampton, UK

    J. A. Poat  & P. J. Roberts  & 

Copyright information

© 1986 The Contributors

About this chapter

Cite this chapter

Piccardi, M.P., Martis, G., Mulas, S., Corsini, G.U. (1986). Down-regulation of Dopamine Autoreceptors by Estrogens: Physiological Control. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-07431-0_26

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-07433-4

  • Online ISBN: 978-1-349-07431-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation