Behavioural Compensation after Dopamine Grafts in Brain
For almost a century attempts have been made to transplant neuronal tissue to the central nervous system of mammals. The conditions for attaining reliable graft survival have now been characterised and the transplantation of CNS tissue to a number of different sites within the adult nervous system can be achieved with a high degree of reliability.
KeywordsFoam Dopamine Tyrosine Morphine Serotonin
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- Aanitia, E.C.; Perlow, M. J.; Brennan, M.J. and Larder, J. M. Fetal raphe and hippocampal transplants in adult and aged C57BL/6N mice: A preliminary inmunocytochemical study. Brain Res. Bull. 7, 703–710.Google Scholar
- Bjorklund, A.; Stenevi, U.; Schmidt, R. H.; Dunnett, J. B. and Gage, F. H. (1983 a) Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation. Acta Physiologica Scandinavica, 1–7Google Scholar
- Bjorklund, A; Stenevi, U.; Schmidt, R.H., Dunnett, S.B. and Gage, F.H. (1983 b) Intracerebral grafting of neuronal cell suspensions II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiologica Scandinavica. Suppl 522, 9–18.Google Scholar
- Dunnett, S.B.; Bjorklund, A.; Stenevi, U. and Iversen, S.D. (1981) Grafts of embryonic substantia nigra reinnervating the ventrolateral striatian ameliorate sensorimotor impairments and akinesia in rats with 6-OHDA lesions of the nigrostriatal pathway. Brain Res. 229, 209–217.PubMedCrossRefGoogle Scholar
- Dunnett, S.B.; Bjorklund, A.; Schmidt R.H.; Stenevi, V. and Iversen S.D. (1983) Intracerebal grafting of neuronal cell suspensions IV Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites. Acta Physiologica Scandinavica. Suppl. 522, 29–37.Google Scholar
- Freund, T.F.; Bolam, J.P.; Bjorklund, A.; Stenevi, U.; Dunnett, S.B.; Powell, J.F. and Smith, A.D. (1984) Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum. Journal of Neuroscience (in press).Google Scholar
- Gage, F.H.; Bjorklund, A.; Stenevi, U. and Dunnett, S.B. (1983) Intracerebral grafting of neuronal cell suspensions VIII. Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged rats. Acta Physiologica Scandinavica 522, 67–75.Google Scholar
- Iversen, S.D. (1984) Cortical Monoamines and Behavior In “Monoamine Innervation of Cerebral Cortex” Neurology and Neurobiology Vol 10 pp 321 – 351 Eds. Descarries, L.; Reader, R.R. and Jasper H.H. Alan R. Liss, Inc., New York.Google Scholar
- Kelly, P.H.; Seviour, P.W. and Iversen, S. D. (1975) amphetamine and apomorphine responses in the rat following 6-OHDA lesions to the nucleus accumbens septi and corpus striatum. Brain Res. 94, 507–522.Google Scholar
- Schmidt, R.H.; Ingvar, M.; Lindvall, O.; Stenevi, U. and Bjorklund, A. (1982) Functional activity of substantia nigra grafts innervating the striatum: Neurotransmitter metabolism and 14C 2-Deoxy-D-glucose autoradiography. J. Neurochem., 38, 737–748.Google Scholar
- Schmidt, R.H.; Bjorklund, A.; Stenevi, U.; Dunnett S.B.; and Gage, F.M. (1983) Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspensions as assessed by measurements of dopamine synthesis and metabolism. Acta. Physiol. Scand. Suppl. 522, 19–28.PubMedGoogle Scholar
- Schultzberg, M.; Dunnett, S.B.; Bjorklund, A.; Stenevi, U.; Hokfelt, T.; Dockray, G.T. and Goldstein, M. (1984) Dopamine and cholecystokinin inmunoreactive neurones in mesencephalon grafts reinnervating the neostriatum: Evidence for selective growth regulation. Neuroscience, 12, 17–32.PubMedCrossRefGoogle Scholar