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Behavioural Compensation after Dopamine Grafts in Brain

  • Chapter
Dopaminergic Systems and their Regulation

Abstract

For almost a century attempts have been made to transplant neuronal tissue to the central nervous system of mammals. The conditions for attaining reliable graft survival have now been characterised and the transplantation of CNS tissue to a number of different sites within the adult nervous system can be achieved with a high degree of reliability.

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References

  • Aanitia, E.C.; Perlow, M. J.; Brennan, M.J. and Larder, J. M. Fetal raphe and hippocampal transplants in adult and aged C57BL/6N mice: A preliminary inmunocytochemical study. Brain Res. Bull. 7, 703–710.

    Google Scholar 

  • Bartus, R.T; Deen, R. L.; Beer B. and Lippa, A. S. (1982) The cholinergic hypotheses of geriatric memory dysfunction. Science 217, 408–417.

    Article  PubMed  CAS  Google Scholar 

  • Bjorklund, A.; Dunnett, S.B.; Stenevi, U.; Lewis, M.E. and Iversen, S.D. (1980) Reinnervation of the denervated striatum by substantia nigra transplants — functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res. 199, 307–333.

    Article  PubMed  CAS  Google Scholar 

  • Bjorklund, A.; Stenevi, U.; Dunnett, S.B. and Gage, F. H. (1982) Cross species neuronal grafting in a rat model of Parkinson’s disease. Nature, 298, 652–654

    Article  PubMed  CAS  Google Scholar 

  • Bjorklund, A.; Stenevi, U.; Schmidt, R. H.; Dunnett, J. B. and Gage, F. H. (1983 a) Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation. Acta Physiologica Scandinavica, 1–7

    Google Scholar 

  • Bjorklund, A; Stenevi, U.; Schmidt, R.H., Dunnett, S.B. and Gage, F.H. (1983 b) Intracerebral grafting of neuronal cell suspensions II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiologica Scandinavica. Suppl 522, 9–18.

    Google Scholar 

  • Cubells, J.F. and Joseph, J.A. (1981) Neostriatal dopamine receptor loss and behavioural deficits in the senescent rat. Life Sci. 28, 1215–1218.

    Article  PubMed  CAS  Google Scholar 

  • Dunnett, S.B.; Bjorklund, A.; Stenevi, U. and Iversen, S.D. (1981) Grafts of embryonic substantia nigra reinnervating the ventrolateral striatian ameliorate sensorimotor impairments and akinesia in rats with 6-OHDA lesions of the nigrostriatal pathway. Brain Res. 229, 209–217.

    Article  PubMed  CAS  Google Scholar 

  • Dunnett, S.B.; Bjorklund, A.; Schmidt R.H.; Stenevi, V. and Iversen S.D. (1983) Intracerebal grafting of neuronal cell suspensions IV Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites. Acta Physiologica Scandinavica. Suppl. 522, 29–37.

    CAS  Google Scholar 

  • Dunnett, S.B.; Bunch, S.T.; Gage, F.H. and Bjorklund, A. (1984) Dopamine-rich transplants in rats with 6-OHDA lesions of the ventral tegmental area. I. Effects on spontaneous and drug-induced locomotor activity. Behav. Brain Res., 13, 71–82.

    Article  PubMed  CAS  Google Scholar 

  • Freund, T.F.; Bolam, J.P.; Bjorklund, A.; Stenevi, U.; Dunnett, S.B.; Powell, J.F. and Smith, A.D. (1984) Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum. Journal of Neuroscience (in press).

    Google Scholar 

  • Gage, F.H.; Bjorklund, A.; Stenevi, U. and Dunnett, S.B. (1983) Intracerebral grafting of neuronal cell suspensions VIII. Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged rats. Acta Physiologica Scandinavica 522, 67–75.

    CAS  Google Scholar 

  • Goldman-Rakic, P.S. and Brown, R.M. (1981) Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neuroscience, 6, 177–187.

    Article  PubMed  CAS  Google Scholar 

  • Iversen, S.D. (1984) Cortical Monoamines and Behavior In “Monoamine Innervation of Cerebral Cortex” Neurology and Neurobiology Vol 10 pp 321 – 351 Eds. Descarries, L.; Reader, R.R. and Jasper H.H. Alan R. Liss, Inc., New York.

    Google Scholar 

  • Kelly, P.H.; Seviour, P.W. and Iversen, S. D. (1975) amphetamine and apomorphine responses in the rat following 6-OHDA lesions to the nucleus accumbens septi and corpus striatum. Brain Res. 94, 507–522.

    Google Scholar 

  • Kubanis, P. and Zornetzer, S. F. (1981) Age-related behavioural and neurobiolocal changes: a review with an emphasis on memory. Behav. and Neural Biol., 31, 155–172.

    Article  Google Scholar 

  • Low, W.C.; Lewis, P.R. and Bunch, S.T. (1983) Embryonic neuronal transplants across a major histo coinpatibility barrier: survival and specificity of innervation. Brain Res. 262, 328–333.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.F. and Teitelbaum, P. (1974) Further analysis of sensory attention following lateral hypthalamic damage in rats. J. Comp. physiol. Psychol., 86, 375–395.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.F. and Berrios, N. (1979) Movement disorders of aged rats: reversal by dopamine receptor stimulation. Science, 206, 477–479.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.F. and Gotthelf, T. (1979) Sensory attention in rats with 6-hydroxy dopamine-induced lesions of ascending dopaminergic neurons: apomorphine-induced reversal of deficits. Exp. Neurol., 65, 389–411.

    Article  Google Scholar 

  • Schmidt, R.H.; Bjorklund, A. and Stenevi, U. (1981). Intracerebral grafting of dissociated CNS tissue suspensions: a new approach for neuronal transplantation to deep brain sites. Brain Res. 218, 347–356.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, R.H.; Ingvar, M.; Lindvall, O.; Stenevi, U. and Bjorklund, A. (1982) Functional activity of substantia nigra grafts innervating the striatum: Neurotransmitter metabolism and 14C 2-Deoxy-D-glucose autoradiography. J. Neurochem., 38, 737–748.

    Google Scholar 

  • Schmidt, R.H.; Bjorklund, A.; Stenevi, U.; Dunnett S.B.; and Gage, F.M. (1983) Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspensions as assessed by measurements of dopamine synthesis and metabolism. Acta. Physiol. Scand. Suppl. 522, 19–28.

    PubMed  CAS  Google Scholar 

  • Schultzberg, M.; Dunnett, S.B.; Bjorklund, A.; Stenevi, U.; Hokfelt, T.; Dockray, G.T. and Goldstein, M. (1984) Dopamine and cholecystokinin inmunoreactive neurones in mesencephalon grafts reinnervating the neostriatum: Evidence for selective growth regulation. Neuroscience, 12, 17–32.

    Article  PubMed  CAS  Google Scholar 

  • Wallace, J.E; Krauter, E. E. and Campbell, B.A. (1980) Animal models of declining memory in the aged: short-term and spatial memory in the aged rat. J. Gerontol., 35, 355–363.

    Article  PubMed  CAS  Google Scholar 

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Iversen, S.D., Dunnett, S.B., Stenevi, U., Bjorklund, A. (1986). Behavioural Compensation after Dopamine Grafts in Brain. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_17

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  • DOI: https://doi.org/10.1007/978-1-349-07431-0_17

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-07433-4

  • Online ISBN: 978-1-349-07431-0

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