Abstract
In experiments with normal rats, we have designed a series of motor tasks in an attempt to produce specific, movement related changes in neurotransmitter turnover in brain. The goal was to study normal brain function without the need for drugs or lesions. We have trained rats to run in circles for a water reward and have also studied animals running at different speeds on straight and circular treadmills. The purpose of these assigned motor tasks was to provoke changes in dopamine turnover in different brain nuclei believed responsible for the expression of motor behavior. The trained circling rat led us to discover that dopamine was released from the caudate nucleus contralateral to the circling direction. The enhanced release was associated with increased tyrosine hydroxylase activity on that side in addition to increased dopamine and DOPAC concentrations. To demonstrate that the changes in dopamine metabolism were related to asymmetric body movement and not to passive movement of the head in space, we studied animals running on a circular treadmill. In this paradigm we found that animals running in a circular path without the head rotating in space had contralateral increases in caudate dopamine turnover.
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Freed, C.R., Yamamoto, B.K. (1986). Dynamic Changes in Brain Dopamine Metabolism During Movement. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_14
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DOI: https://doi.org/10.1007/978-1-349-07431-0_14
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