The Investigation Of Biomaterials By Sequential Plasmaperfusion
Significant neutropenia regularly accompanies the early phase of haemodialysis using dialysers with cellulose membranes (Craddock et al., 1977). This neutropenia is associated with a complement activation, which occurs when blood comes into contact with the cellulose membrane of the dialyser. The disappearance of neutrophils seems to reflect an increased aggregability of the granulocytes, producing leuco-embolisation with tissue damage in such diverse clinical situations as pulmonary dysfunction in haemodialysis patients, sudden blindness with retinal infarction, acute pancreatitis, myocardial infarction and adult respiratory distress syndrome (Jacob et al., 1980a). The phenomenon is also correlated with an impairment of the chemotactic activity and migration index of the granulocytes, leading to a possible increased susceptibility of dialysis patients to bacterial infection (Wierusz-Wysocka et al., 1983). It has been reported (Wysocki et al., 1981) that granular proteins caused by neutrophil degranulation are responsible for the complement activation during haemodialysis with Cuprophan regenerated cellulose membranes and there is evidence to support the assumption that an activation of the complement system is responsible for most of the described deviations of granulocytes (Craddock et al., 1977; McGillen and Phair, 1979; Hammerschmidt et al., 1980; Ivanovich et al., 1983). The factor C5a, having a molecular weight of 7000–20 000, has been regarded as the factor of the complement system mainly responsible (Hammerschmidt et al., 1980).
KeywordsWhite Blood Cell Complement Activation Complement System Adult Respiratory Distress Syndrome Cellulose Membrane
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