Abstract
In the past few years, pharmacokinetics has been establishing itself as an essential part of patient care. Its use by different members of the health care team has been variable, which in part may be due to the number of apparently complicated formulae and different symbols that are used. Nevertheless, when relating pharmacokinetics to the clinical situation, in which case it is more appropriately called clinical pharmacokinetics, a few simple guidelines enable pharmacokinetic data to be used in an uncomplicated fashion during patient care. This should lead to a more rational use of drug therapy and thus result in an improvement in patient care.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aaronson, J. K. (1980). Clin. Pharmacokin. 5, 137–49.
Aaronson, J. K., and Grahame-Smith, D. G. (1976). Brit. J. Clin. Pharmacol. 3, 1045–51.
Aaronson, J. K., Grahame-Smith, D. G., and Wigley, F. M. (1978). Quart. J. Med. 47, 111–22.
Bateman, D. N., Kahn, C., and Davies, D. S. (1980). Brit. J. Clin. Pharmacol. 9, 371–7.
Borga, O., Piafsky, K. M., and Nilsen, G. (1977). Clim. Pharmacol. Ther. 22, 539–44.
Boyd, J., Covington, T. R., and Stanaszek, W. F. (1974). Am. J. Hosp. Pharm. 31, 362–7.
Braithwaite, R., Montgomery, S., and Dawling, S. (1978). Clin. Pharmacol. Ther. 23, 303–8.
Brooker, G., and Jelliffe, R. W. (1972). Circulation 45, 20–36.
Burnett, G. H., and Conklin, R. L. (1968). J. Lab. Clin. Med. 71, 1040–50.
Chang, J. J., Crowl, C. P., and Schneider, R. S. (1975). Clin. Chem. 21, 967.
Cooper, T. B., Bergner, P.-E. E., and Simpson, G. M. (1973). Am. J. Psychiatr. 130, 601–3.
Cooper, T. B., and Simpson, G. M. (1978). Am. J. Psychiatr. 135, 333–5.
Curry, S. H. (1968). Analyt. Chem. 40, 1251–6.
Curry, S. H. (1980). Drug Disposition and Pharmacokinetics (3rd ed.), Blackwell Scientific Publications, Oxford, 131–44.
Curry, S. H., Mould, G. P., and D’Mello, A. (1971). Brit. J. Pharmacol. 42, 403–11.
Dawling, S., Crome, P., and Braithwaite, R. (1980). Clin. Pharmacokin. 5, 394–401.
Dhillon, S., Oxley, J., and Richens, A. (1982). Brit. J. Clin. Pharmacol. 13, 427–32.
Dobbs, S. M., Mawer, G. E., Rodgers, E. M., Woodcock, B. G., and Lucas, S. B. (1977). Brit. J. Clin. Pharmacol. 3, 231–7.
Dollery, C. T., Davies, D. S., and Conolly, M. E. (1971). N.Y. Ann. Acad. Sci. 179, 109–12.
Dougall, J. R., Cunningham, B., and Nimmo, W. S. (1983). Brit. J. Clin. Pharmacol. 15, 487–9.
Eadie, M. J., Lander, C. M., and Tyrer, J. H. (1977). Clin. Pharmacokin. 2, 427–36.
George, C. F. (1979). Clin. Pharmacokin. 4, 433–48.
Gibaldi, M. (1984). Biopharmaceutics and Pharmacokinetics (3rd ed.), Lea and Febiger, Philadelphia, 17–28.
Gibson, T. P., and Nelson, H. A. (1980). Clin. Pharmacol. Ther. 27, 219–23.
Gillis, A. M., and Kates, R. E. (1984). Clin. Pharmacokin. 9, 375–403.
Gram, L. (1977). Dan. Med. Bull. 24, 81–9.
Gram, L. F., and Overo, K. F. (1975). Clin. Pharmacol. Ther. 18, 305–14.
Gugler, R., Manion, C. V., and Azarnoff, D. L. (1976). Clin. Pharmacol. Ther. 19, 135–42.
Hendeles, L., Iafrate, R. P., and Weinberger, M. (1984). Clin. Pharmacokin. 9, 95–135.
Hendeles, L., Weinberger, M., and Brighley, L. (1977). Am. J. Hosp. Pharm. 34, 525–7.
Holt, D. W., Tucker, G. T., Jackson, P. R., and Storey, G. C. (1983). Amer. Heart J. 106, 840–6.
Hook, G. E. R., Bend, J. H. R., Hoel, D., Foutts, J. R., and Gram, T. E. (1972). J. Pharmacol. Exp. Ther. 182, 474–90.
Hunninghake, D. B., and King, S. (1978). Pharmacologist 20, 220.
lisalo, E. (1977). Clin. Pharmacokin. 2, 1–16.
Johnston, G. D., and McDevitt, D. G. (1978). Brit. J. Clin. Pharmacol. 6, 339–43.
Kelman, A. W., Whiting, B., and Bryson, S. M. (1982). Brit. J. Clin. Pharmacol. 14, 247–56.
Kennedy, M. C., and Wade, D. M. (1979). Brit. J. Clin. Pharmacol. 7, 515–18.
Klein, H. O., Lang, R., DeSegri, E., and Kaplinsky, E. (1980). New Engl. J. Med. 303, 160.
Koch-Weser, J. (1972). New Engl. J. Med. 287, 227–31.
Koup, J. R., Greenblatt, D. J., Jusko, W. J., Smith, T. W., and Koch-Weser, J. (1975). J. Pharmacokin. Biopharm. 3, 181–92.
Koup, J. R., Sack, C. M., Smith, A. L., and Gibaldi, M. (1979). Clin. Pharmacokin. 4, 460–9.
Lindenbaum, J., Mellow, M. H., Blackstone, M. O., and Butler Jr, V. P. (1970). New Engl. J. Med. 285, 1344–7.
Little, P. J., Jennings, G. L., Skews, H., and Bobik, A. (1982). Brit. J. Clin. Pharmacol. 13, 785–90.
Lott, R. S., and Hayton, W. L. (1978). Drug Intell. Clin. Pharm. 12, 140–8.
Lowenstein, J. W., and Corrill, E. M. (1966). J. Lab. Clin. Med. 68, 1048–52.
McNeil, J. J., and Louis, W. J. (1984). Clin. Pharmacokin. 9, 157–67.
Marks, V., Morris, B. A., and Teale, J. D. (1974). Brit. Med. Bull. 30, 80–6.
Melander, A., Danielson, K., Schersten, B., and Wahn, E. (1977). Clin. Pharm. Ther. 22, 108–12.
Metzler, C. M., Elfring, G. L., and McEwan, A. J. (1974). Biometrics 30, 562–3.
Moolenaar, F., Greving, W. J., and Huizanga, T. (1982). Int. J. Pharm. 5, 127–37.
Moore, A., Sear, J., Baldwin, D., Allen, M., Hunniset, A., Bullingham, R., and McQuay, M. (1984). Clin. Pharmacol. Ther. 35, 461–5.
Mould, G. P. (1977). An Intestinal Mixed-function Oxidase System of Potential Importance in Biopharmacy. PhD Thesis, University of London.
Mould, G. P. (1978). Brit. J. Pharmacol. Practice 3, 22–4.
Mould, G. P., Aherne, G. W., Morris, B. A., Teale, J. D., and Marks, V. (1977). Europ. J. Drug Metab. Pharmacokin. 4, 171–84.
Mould, G. P., Clough, J., Marks, V., Levinson, N. L., Townsend, H. A., and Cummings, S. W. (1982). J. Clin. Hosp. Pharm. 7, 281–6.
Mould, G. P., Clough, J., Stout, G., Morris, B. A., and Marks, V. (1981). Biopharmac. Drug Disposit. 2, 49–57.
Mould, G. P., and Marks, V. (1986). (In preparation).
Mould, G. P., Morris, B. A., Marks, V., Malan, P. G., and Ekins, R. (1979). Abstracts of Papers and Posters — Third European Congress of Clinical Chemistry, Brighton.
Nelson, K., and Bowers, L. D. (1983). Clin. Chem. 29, 1175.
Neuvonen, P. J. (1979). Clin. Pharmacokin. 4, 91–103.
Nimmo, W. S., Heading, R. C., Wilson, J., Tothill, P., and Prestcott, L. F. (1975). Brit. J. Clin. Pharmacol. 2, 509–13.
Ogilvie, R. I. (1978). Clin. Pharmacokin. 3, 267–93.
Oliver Jr, G. C., Parker, B. M., Brasfield, D. L., and Parker, C. W. (1968). J. Clin. Invest. 47, 1035–42.
Pederson, K. E., Dorph-Pederson, A., Hvidt, S., Klitgaard, N. A., and Neilsen-Kuds, K. F. (1981). Clin. Pharmacol. Ther. 30, 311–16.
Perucca, E., Richens, A., and Ruprah, M. (1981). Brit. J. Clin. Pharmacol. 11, 409P–10P.
Piafsky, K. M., and Borga, O. (1977). Clin. Pharmacol. Ther. 22, 545–9.
Piafsky, M., Borga, O., Odar-Cederlof, I., Johanssen, C., and Sjoqvist, F. (1979). New Engl. J. Med. 299, 1435–9.
Pudek, M. R., Seccombe, D. W., Jacobson, B. E., and Whitfield, M. F. (1983). Clin. Chem. 29, 1972–4.
Ramsbottom, N., and Hunt, J. N. (1974). Digestion 10, 1–8.
Reitberg, D. P., Bernhard, H., and Schentag, J. J. (1981). Ann. Int. Med. 95, 582–5.
Richens, A. (1978). Brit. J. Clin. Pharmacol. 5, 285–8.
Richens, A., Marks, V. (eds.), (1981) Therapeutic Drug Monitoring, Churchill Livingstone, London.
Rivera-Calimlin, L., Morgan, J. P., Dujovne, C. A., Bianchine, J. R., and Lasagna, L. (1971). Biochem. Pharmacol. 20, 3051–7.
Ross-Lee, L., Eadie, M. J., Hooper, W. D., and Bochner, F. (1981). Europ. J. Clin. Pharmacol. 20, 465–71.
Rowland, M., and Tozer, T. N. (1980). Clinical Pharmacokinetics: Concepts and Applications, Lea and Febiger, Philadelphia.
Schapira, A. (1984). Clin. Pharmacokin. 9, 360–70.
Scheline, R. R. (1968). Pharmac. Rev. 25, 451–523.
Shand, D. G., Hammill, S. C., Aanonsen, L., and Pritchett, E. L. C. (1981). Clin. Pharmacol. Ther. 30, 701–3.
Sheiner, L. B., and Beal, L. S. (1979). J. Pharm. Sci. 71, 1344–8.
Sheiner, L. B., Beal, S. L., Rosenberg, B., and Marathe, V. V. (1979). Clin. Pharmacol. Ther. 26, 294–305.
Shoeman, D. W., and Azarnoff, D. L. (1972). Pharmacology 7, 169–77.
Sjöqvist, F. (1984). Therapeutic drug monitoring — twenty years’ experience. In: Lemberger, L., and Reidenberg, M. M. (eds.), Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics. American Society for Pharmacology and Experimental Therapeutics, Washington, 38–63.
Slattery, J. T., Gibaldi, M., and Koup, J. R. (1980). Clin. Pharmacokin. 5, 377–85.
Smith, T. W., Butler Jr, V. P., and Haber, E. (1969). New Engl. J. Med. 281, 1212–16.
Somogyi, A., Thielscher, S., and Gugler, R. (1981). Europ. J. Clin. Pharmacol. 19, 343–7.
Starkey, B. J., and Mould, G. P. (1984). Ther. Drug. Monit. 6, 322–7.
Steiness, E., Svendsen, O., and Rasmussen, F. (1974). Clin. Pharmacol. Ther. 16, 430–4.
Stevenson, D., Briggs, R., and Mould, G. P. (1986). J. Pharm. Biomed. Analysis (in press).
Thomson, P. D. (1973). Ann. Int. Med. 78, 499–504.
Toothaker, R. D., and Welling, P. G. (1980). Ann. Rev. Pharmacol. Toxicol. 20, 173–99.
Tsanaclis, L. M., Allewn, J., Perucca, E., Routledge, P. A., and Richens, A. (1984). Brit. J. Clin. Pharmacol. 18, 17–20.
Tyrer, J. H., Eadie, M. J., Sutherland, J. M., and Hooper, W. D. (1971). Brit. Med. J. 4, 271–3.
Vozeh, S., Muir, K. T., Follath, F., and Sheiner, L. B. (1981). J. Pharmacokin. Biopharm. 9, 131–44.
Walker, C. A., and Kopp, B. (1978). Antimicrob. Agents Chemother. 13, 30–3.
Watson, E., and Kalman, S. M. (1971). J. Chromatogr. 56, 209–18.
Welling, P. G. (1980). Pharm. Internat. 1, 14–18.
Wilkinson, G. R., and Shand, D. G. (1975). Clin. Pharmacol. Ther. 18, 377–90.
Williams, R. T. (1959). In: The Metabolism and Detoxification of Drugs, Toxic Substances and Other Organic Compounds. Wiley, New York.
Editor information
Copyright information
© 1986 The contributors
About this chapter
Cite this chapter
Mould, G.P. (1986). Pharmacokinetics and Patient Care. In: Curry, A.S. (eds) Analytical Methods in Human Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07244-6_5
Download citation
DOI: https://doi.org/10.1007/978-1-349-07244-6_5
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-07246-0
Online ISBN: 978-1-349-07244-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)