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Adverse Reactions In Humans Thought To Be Related To Ingestion Of Elevated Levels Of Free Monosodium Glutamate (Msg) (Chinese Restaurant Syndrome And Other Reactions)

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Excitotoxins

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

Monosodium glutamate is widely used as a flavor enhancer. A number of adverse effects in humans have been attributed to ingestion of this substance. The most well known of these is the so-called Chinese Restaurant Syndrome. Various studies have been done to attempt to substantiate that glutamate is indeed the etiologic factor responsible for the reported symptoms. No measurable signs appear to be associated with the syndrome. Symptoms can be quite frightening but appear to be transient and rely on subjective reports of reactors. Other adverse reactions, presumably associated with ingestion of glutamate, are also discussed.

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References

  • Albert, E.N. (1979). J. Microwave Power, 14, 281–285.

    CAS  Google Scholar 

  • Albert, K., P. Hoch and H. Waelsch (1946). J. Nerv. Ment. Dis., 104, 263–274.

    Google Scholar 

  • Allen, D.H., and G.J. Baker (1981). N. Engl. J. Med., 305, 1154–1155.

    Google Scholar 

  • Alston, R.M. (1976). N. Engl. J. Med., 294, 225.

    Google Scholar 

  • Ambos, M., N.R. Leavitt, L. Marmorek and S.B. Wolschina (1968). N. Engl. J. Med., 279, 105.

    Google Scholar 

  • Andermann, F., M. Vanosse and L.S. Wolfe (1976). N. Engl. J. Med., 295, 174.

    Google Scholar 

  • Asnes, R.S. (1980). Clin. Pediatr. (Philadelphia), 19, 705–706.

    Google Scholar 

  • Bakay, L. (1972). In: Handbook of Neurochemistry, Laitha, A., ea. Plenum Press, New York, 417–427.

    Google Scholar 

  • Bazzano, G., J.A. D’Elia and R.E. Olson (1970). Science, 18, 1208–1209.

    Article  Google Scholar 

  • Bellhorn, R.W., D.A. Lipman, J. Confino and M.S. Burns (1981). Invest. Ophthalmol. Vis. Sci., 21, 237–247.

    Google Scholar 

  • Berry, H.K., R.E. Butcher, L.A. Elliot and R.L. Brunner (1974). Dev. Psychobiol., 7, 165–173.

    Article  CAS  PubMed  Google Scholar 

  • Bodnar, R.J., G.M. Abrams, E.A. Zimmerman, D.T. Krieger, G. Nicholson and J.S. Kizer (1980). Neuroendocrinology, 30, 280–284.

    Article  CAS  PubMed  Google Scholar 

  • Carter, L.T., and L. Levesque (1979). Neurobehav. Toxicol., 1, 247–251.

    CAS  PubMed  Google Scholar 

  • Colman, A.D. (1978a). N. Engl. J. Med., 299, 902.

    Google Scholar 

  • Colman, A.D. (1978b). N. Engl. J. Med., 300, 503.

    Google Scholar 

  • Conacher, H.B., J.R. Iyengar, W.F. Miles and H.G. Botting (1979). J. Assoc. Off. Anal. Chem., 62, 604–609. Consumer Reports (1978). 615–619.

    Google Scholar 

  • Cooper, P. (1977). Fd. Cosmet. Toxicol., 15, 347–356.

    Google Scholar 

  • Creasey, W.A., and S.E. Malawista (1971). Biochem. Pharmacol. 20, 2917–2920.

    Article  CAS  PubMed  Google Scholar 

  • Cunha-Vaz, J., F. De Abreu, A.J. Campos and G.M. Figo (1975). Br. J. Ophthalmol. 59, 649–656.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dawson, R., Jr., J.J. Valdes and Z. Annau (1982). Neuroendocrinology, 34, 292–296. Department of Health, Education and Welfare (1974). FDA publication #74–2043. Washington, D.C.

    Google Scholar 

  • Dhindsa, K.S., R.G. Omran and R. Bhup (1981). Acta Anat., 109, 97–102.

    Article  CAS  PubMed  Google Scholar 

  • Folkers, K., S. Shizukuishi, S.L. Scudder, R. Willis, K. Takemura and J.B. Longenecker (1981). Biochem. Biophys. Res. Comm., 100, 972–977.

    Google Scholar 

  • Gann, D. (1977). South. Med. J., 70, 879–881.

    Google Scholar 

  • Ghadimi, H. (1973). Am. J. Clin. Nutr., 26, 686–687.

    Google Scholar 

  • Ghadimi, H., C.L. Bhalla and D.M. Kirchenbaum (1970). Acta Paediatr. Scand. 59, 233–240.

    Article  CAS  PubMed  Google Scholar 

  • Ghadimi, H., and S. Kumar (1972). Am. J. Clin. Nutr., 25, 643–646.

    Google Scholar 

  • Ghadimi, H., S. Kumar and F. Abaci (1971). Biochem. Med., 5, 447–456.

    Article  CAS  Google Scholar 

  • Ghezzi, P., M. Salmone, M. Recchia, G. Dagnino and S. Garattini (1980). Toxicol. Lett., 5, 417–421.

    Article  CAS  PubMed  Google Scholar 

  • Goodman, L.S., E.A. Swinyard and J.E.P. Toman (1946). Arch. Neurol. Psychiat., 56, 20.

    Google Scholar 

  • Gore, M.E., and P.R. Salmon (1980). Lancet, 1, 251–252.

    Article  CAS  PubMed  Google Scholar 

  • Hammerschmidt, D.E. (1980). N. Engl. J. Med., 302, 1191–1193.

    Google Scholar 

  • Himms-Hagen, J. (1970). Nature, 228, 97.

    Article  CAS  PubMed  Google Scholar 

  • Himwich, H.E., K. Wolff, A.L. Hunsicker and W.A. Himwich (1955). J. Nerv. Ment. Dis., 121, 40.

    Google Scholar 

  • Johnston, G.A.R. (1973). Biochem. Pharm. 22:137–140.

    Article  CAS  PubMed  Google Scholar 

  • Justesen, D.R. (1980). Proc. IEEE, 68, 60–67.

    Article  CAS  Google Scholar 

  • Kandall, S.R. (1968). N. Engl. J. Med., 278, 1123.

    Google Scholar 

  • Kenney, R.A. (1978). N. Engl. J. Med., 300, 503.

    Google Scholar 

  • Kenney, R.A. (1979). In: Glutamic Acid: Advances in Biochemistry and Physiology. Filer, L.J. Jr. et al, eds. Raven Press, New York, 363–373.

    Google Scholar 

  • Kenney, R.A., and C.S. Tidball (1972). Am. J. Clin. Nutr., 25, 140–146.

    Google Scholar 

  • Kerr, G.R., M. Wu-Lee, M. El-lozy, R. McGandy and F.J. Stare (1979). J. Am. Diet Assoc., 75, 29–33.

    Google Scholar 

  • Kirkendol, P.L., J.E. Pearson and N.W. Robie (1980). Clin. Exp. Pharmacol. Physiol., 7, 617–625.

    Google Scholar 

  • Komeda, K., M. Yokote and Y. Oki (1980). Experientia, 36, 232–234.

    Article  CAS  PubMed  Google Scholar 

  • Krieger, D.T., A.S. Liotta, G. Nicholsen and J.S. Kizer (1979). Nature, 278, 562–563.

    Article  CAS  PubMed  Google Scholar 

  • Kwok, R.H.M. (1968). N. Engl. J. Med., 278, 796.

    Google Scholar 

  • Levey, S., J.E. Harroun and S.J. Smyth (1949). J. Lab. Clin. Med., 34, 1238–1248.

    Google Scholar 

  • Lott, I.T., T. Coulombe, R.V. DiPaolo, E.P. Richardson Jr. and H.L. Levy (1978). Neurology, 28, 47–54.

    Article  CAS  PubMed  Google Scholar 

  • McCall, A., B.S. Glaeser, W. Millington and R.J. Wurtman (1980). Neurobehav. Toxicol., 1, 279–283.

    Google Scholar 

  • Marrs, T.C., M. Salmone, S. Garattini, D. Burston and D.M. Mathews (1978). Toxicology, 11, 101–107.

    Article  CAS  PubMed  Google Scholar 

  • Marshall, A.E. (1948). Monosodium Glutamate, A Symposium. Quartermaster Food and Container Institute for the Armed Forces, and Associates. Chicago, Ill. 4.

    Google Scholar 

  • Mayer-Gross, W., and J.W. Walker (1949). Biochem. J., 44, 92–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Merritt, J.H., A.F. Chamness and S.J. Allen (1978). Radiat. Environ. Biophys., 15, 367–377.

    Google Scholar 

  • Moneysworth (Feb. 1975), 23. Morselli, P.L., and S. Gara Hini (1970). Nature, 227, 611.

    Article  Google Scholar 

  • Nemeroff C.B., and F.D. Crisley (1975). Environ. Physiol. Biochem., 5, 389–395.

    Google Scholar 

  • Neumann, H.H. (1976). Am. Heart J., 92, 266.

    Article  CAS  PubMed  Google Scholar 

  • New York International Glutamate Technical Committee (1974). The Remarkable Story of Monosodium Glutamate, Food and Drug Administration, Washington, D.C.

    Google Scholar 

  • Nitch, C. (1976). Acta Neurochir. (Wien) 23:Suppl, 101.

    Google Scholar 

  • Olney, J.W. (1975). In: Sweetners: Issues and Uncertainties. National Academy of Science Forum, G.P.O., Washington, D.C.

    Google Scholar 

  • Olney, J.W. (1976). In: Transport Phenomena in the Nervous System: Physiological and Pathological Aspects (Advances in Experimental Medicine and Biology 69) Levi G. et al, eds. Plenum Press, New York, 497–506.

    Google Scholar 

  • Olney, J.W. (1980). Neurotoxicology, 2, 163–192.

    Google Scholar 

  • Pardridge, W.M., J.D. Connor and I.L. Crawford (1975). CRC Crit. Rev. Toxicol., 3, 159–199. Peter, R.E., O. Kah, C.R. Paulencu, H. Cook and A.L. Kyle (1980). Cell Tissue Res., 212, 429–442. Plaitakis, A., S. Berl, and M.D. Yahr (1982). Science, 216, 193–196.

    Google Scholar 

  • Rath, J. (1968). N. Engl. J. Med., 278, 1123.

    Google Scholar 

  • Reif-Lehrer, L. (1976a). Fed. Proc. 35, 2205–2212.

    CAS  PubMed  Google Scholar 

  • Reif-Lehrer, L. (1976b). Pediatrics, 58, 771.

    CAS  PubMed  Google Scholar 

  • Reif-Lehrer, L. (1977a). Yearbook of Pediatrics, 309–310.

    Google Scholar 

  • Reif-Lehrer, L. (1977b). Fed. Proc., 36, 1617–1623.

    CAS  PubMed  Google Scholar 

  • Reif-Lehrer, L. (1977c). Testimony, Federation of American Societies for Experimental Biology, Bethesda, Md.

    Google Scholar 

  • Reif-Lehrer, L. (1982, in press). Chapter in: Current Topics in Eye Research. Academic Press, New York.

    Google Scholar 

  • Reif-Lehrer, L., and M.G. Stemmermann (1975). N. Engl. J. Med., 293, 1204–1205.

    Google Scholar 

  • Reinken, L. (1975). Acta Vitaminol. Enzymol. (Milano), 29, 252–

    Google Scholar 

  • Reynolds, W.A., V. Butler and N. Lemkey-Johnston (1976). J. Toxicol. Environ. Health, 2, 471–480.

    Google Scholar 

  • Rippere, V. (1981). Med. Hypotheses, 7, 819–823.

    Article  CAS  PubMed  Google Scholar 

  • Roberts, P.J., J. Storm-Mathisen and G.A.R. Johnston, eds. (1981). Glutamate: Transmitter in the Central Nervous System. John Wiley & Sons, New York.

    Google Scholar 

  • Rodriguez-Sierra, J.F., R. Sridaran and C.A. Blake (1980). Neuroendocrinology, 31, 228–235.

    Article  CAS  PubMed  Google Scholar 

  • Rosenblum, I., J.D. Bradley and F. Coulston (1971). Toxicol. Appl. Pharmacol., 18, 367–373.

    Google Scholar 

  • Rubini, M.E. (1971). Am. J. Clin. Nutr. 24, 169–171.

    Google Scholar 

  • Saphier, D.J., and R.G. Dyer (1981). J. Endocrinol., 89, 379–387.

    Article  CAS  PubMed  Google Scholar 

  • Schaumburg, H.H. (1968). N. Engl. J. Med., 278, 1122.

    Google Scholar 

  • Schaumburg, H.H., and R. Byck (1968). N. Engl. J. Med., 279, 105.

    Google Scholar 

  • Schaumburg, H.H., R. Byck, R. Gerstl and J.H. Mashman (1969). Science, 163, 826.

    Article  CAS  PubMed  Google Scholar 

  • Schubert, F., J.M. George and M. Bhaskar Rao (1980). Life Sciences, 26, 651–656.

    Article  CAS  PubMed  Google Scholar 

  • Scriver, C.R., and D.T. Whelan (1969). Ann. N.Y. Acad. Sci., 166, 83–86.

    Google Scholar 

  • Sjöström, L.B. (1955). Monosodium Glutamate: A Second Symposium. Research and Development Associates, Food and Container Inst., Inc. 31.

    Google Scholar 

  • Smith, R.J. (1981). Science, 213, 986–987.

    Article  CAS  PubMed  Google Scholar 

  • Stegink, L.D., L.J. Filer, Jr., G.L. Baker, S.M. Mueller and MY-C Wu-Ridout (1979). In: Glutamic Acid: Advances in Biochemistry and Physiology, Filer L.J., Jr. et al, eds. Raven Press, New York, 333–351.

    Google Scholar 

  • Stegink, L.D., L.J. Filer, Jr. and G.L. Baker (1981). Am. J. Clin. Nutr., 34, 1899–1905.

    Google Scholar 

  • Sworczak, K., M. Siekjerska and R. Komarnicka (1980). Pol. Tyg. Lek., 35, 991–992.

    Google Scholar 

  • Terry, L.C., J. Epelbaum and J.B. Martin (1981). Brain Res., 217, 129–142.

    Article  CAS  PubMed  Google Scholar 

  • Tracor-Jitco, Inc. (1974). Scientific literature reviews on generally recognized as safe (GRAS) food ingredients — glutamates. Food and Drug Administration, Washington, D.C.

    Google Scholar 

  • Trauberman, L. (1960). Food Engineering.

    Google Scholar 

  • Tursky, T., M. Lassanova, M. Sramka and P. Nadvorink (1976). Acta Neurochir. (Wien) 23:Suppl., 111.

    Google Scholar 

  • Unna, D., and E.E. Howe (1945). Fed. Proc., 4, 138.

    Google Scholar 

  • Utsumi, M., Y. Hirose, K. Ishihara, H. Makimura and S. Baba (1980) Biomed. Res. 1, Suppl., 154–158.

    Google Scholar 

  • Weil-Malherbe, H. (1949). J. Ment. Sc., 95, 930–944.

    Google Scholar 

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Reif-Lehrer, L. (1983). Adverse Reactions In Humans Thought To Be Related To Ingestion Of Elevated Levels Of Free Monosodium Glutamate (Msg) (Chinese Restaurant Syndrome And Other Reactions). In: Fuxe, K., Roberts, P., Schwarcz, R. (eds) Excitotoxins. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06963-7_24

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