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Identification of Excitatory Amino Acid Pathways in the Mammalian Nervous System

  • Chapter
Excitotoxins

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

Although the short-lasting excitatory action of glutamate on neurons was demonstrated more than 20 years ago (Curtis and Watkins, 1960), it has proved difficult to confirm its role as a neurotransmitter in the mammalian CNS. Unlike other putative neurotransmitters, glutamate fullfills a multitude of tasks in the brain. It is involved in energy metabolism and fatty acid synthesis, incorporated into proteins and peptides and is even a precursor for the inhibitory neurotransmitter GABA. In addition its action as a neuroexcitant has been regarded as universal and non-specific.

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Author information

Authors and Affiliations

  1. Division of Toxicology, Norwegian Defence Research Establishment, P. O. Box 25, N-2007 Kjeller, Norway

    F. Fonnum, V. M. Fosse & C. N. Allen

Authors
  1. F. Fonnum
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  2. V. M. Fosse
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  3. C. N. Allen
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Editor information

Editors and Affiliations

  1. Department of Histology, Karolinska Institutet, Stockholm, Sweden

    Kjell Fuxe

  2. Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, England

    Peter Roberts

  3. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Robert Schwarcz

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© 1983 The Wenner-Gren Center

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Fonnum, F., Fosse, V.M., Allen, C.N. (1983). Identification of Excitatory Amino Acid Pathways in the Mammalian Nervous System. In: Fuxe, K., Roberts, P., Schwarcz, R. (eds) Excitotoxins. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06963-7_1

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