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Primidone in essential tremor

  • Chapter
Movement Disorders: Tremor

Abstract

Essential tremor, with its senile and familial varieties, is a common disorder (Marshall, 1968; Critchley, 1949; Rautakorpi et al., this volume, chapter 14) which, although usually prefixed with the adjective ‘benign’, frequently produces significant disability. As yet there is no satisfactory drug available that can predictably control essential tremor. Alcohol can be effective in reducing or abolishing the tremor in some patients (Growdon et al., 1975). However, this is an impracticable therapy and the effect is not specific to essential tremor. At present beta-adrenoceptor antagonists, in particular propranolol, have proven to have the most therapeutic benefit in attenuating the tremor (Morgan et al., 1973; Winkler and Young, 1974; Tolosa and Loewenson, 1975; McAllister et al., 1977; Calzetti et al., 1982).

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References

  • Baruzzi, A., Procaccianti, G., Martinelli, P., Riva, R., Denoth, E., Montanaro, N. and Lugaresi, E. (1983). Phenobarbital and propranolol in essential tremor: a double-blind controlled clinical trial. Neurology (Cleveland), 33, 296–300.

    Article  CAS  Google Scholar 

  • Baumel, I. P., Gallagher, B. B., DiMicco, H. and Goico, H. (1973). Metabolism and anticonvulsant properties of primidone in the rat. J. Pharmacol. Exp. Ther., 186, 305–14.

    CAS  PubMed  Google Scholar 

  • Calzetti, S., Findley, L. J., Gresty, M. A., Perucca, E. and Richens, A. (1981a). Metoprolol and propranolol in essential tremor: a double blind controlled study. J. Neurol. Neurosurg. Psychiatr., 44, 814–19.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Calzetti, S., Findley, L. J., Perucca, E. and Richens, A. (1982). Controlled study of metoprolol and propranolol during prolonged administration in patients with essential tremor. J. Neurol. Neurosurg. Psychiatr., 45, 893–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Calzetti, S., Findley, L. J., Pisani, F. and Richens, A. (1981b). Phenylethylmalonarnide in essential tremor. A double blind controlled study. J. Neurol. Neurosurg. Psychiatr., 44, 932–4.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Critchley, M. (1949). Observations on essential (heredofamilial) tremor. Brain, 72, 113–39.

    Article  CAS  PubMed  Google Scholar 

  • Feely, M. P. (1981). Benign familial tremor treated with primidone. Br. Med. J., 282, 740–1.

    Article  CAS  Google Scholar 

  • Findley, L. J. and Calzetti, S. (1982). Double-blind controlled study of primidone in essential tremor: preliminary results. Br. Med. J., 285, 608–9.

    Article  CAS  Google Scholar 

  • Growdon, J. H., Shahani, B. T. and Young, R. R. (1975). The effect of alcohol on essential tremor. Neurology (Minneap.), 25, 259–62.

    Article  CAS  Google Scholar 

  • Harvey, S. C. (1980). Hypnotics and sedatives. In Gilman, A. G., Goodman, L. S. and Gilman, A. (eds), The Pharmacological Basis of Therapeutics, Macmillan, New York, pp. 339–75.

    Google Scholar 

  • McAllister, R. J. Jr, Markesbery, W. R., Ware, R. W. and Howell, S. M. (1977). Suppression of essential tremor by propranolol: correlation of effect with drug plasma levels and intensity of beta blockade. Ann. Neurol., 1, 160–6.

    Article  PubMed  Google Scholar 

  • McClellan, D. L. and Hassan, N. (1980). A double blind comparison of single doses of DS 103–282, baclofen and placebo in the suppression of spasticity. J. Neurol. Neurosurg. Psychiatr., 43, 1132–6.

    Article  Google Scholar 

  • Marshall, J. (1968). Tremor. In Vinken, P. J. and Bruyn, G. W. (eds), Handbook of Clinical Neurology, vol. 6, North-Holland, Amsterdam, pp. 809–25.

    Google Scholar 

  • Morgan, M. H., Hewer, R. L. and Cooper, R. (1973). Effect of the beta adrenergic blocking agent, propranolol, on essential tremor. J. Neurol. Neurosurg. Psychiatr., 36, 618–24.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • O’Brien, M. D., Upton, A. R. and Toseland, P. A. (1981). Benign familial tremor treated with primidone. Br. Med. J., 282, 178–80.

    Article  Google Scholar 

  • Procaccianti, G., Agostino, B., Martinelli, P., Pazzaglia, P. and Lugaresi, E. (1981). Benign familial tremor treated with primidone. Br. Med. J., 283, 558.

    Article  CAS  Google Scholar 

  • Tolosa, E. S. and Loewenson, R. B. (1975). Essential tremor, treatment with propranolol. Neurology (Minneap.), 25, 1041–4.

    Article  CAS  Google Scholar 

  • Winkler, G. F. and Young, R. R. (1974). Efficacy of chronic propranolol therapy in action tremors of the familial senile or essential varieties. New Engl. J. Med., 290, 984–8.

    Article  CAS  PubMed  Google Scholar 

  • Woodbury, D. M. and Pippenger, C. E. (1982). Primidone. Mechanisms of action. In Woodbury, D. M., Kiffin Penry, J. and Pippenger, C. E. (eds), Antiepileptic Drugs, Raven Press, New York, pp. 449–52.

    Google Scholar 

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Authors
  1. L. J. Findley
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  2. S. Calzetti
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  3. L. Cleeves
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Editor information

Editors and Affiliations

  1. Regional Centre for Neurology and Neurosurgery, Oldchurch Hospital, Romford, UK

    Leslie J. Findley (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist) & Rudy Capildeo (Consultant Neurologist) (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist) &  (Consultant Neurologist)

  2. Harold Wood Hospital, Romford, Essex, UK

    Leslie J. Findley (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist) (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist)

  3. Queen Elizabeth Military Hospital, Woolwich, London, UK

    Leslie J. Findley (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist) (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist)

  4. MRC Neuro-Otology Unit, Institute of Neurology, The National Hospital, Queen Square, London, UK

    Leslie J. Findley (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist) (Consultant Neurologist, Visiting Consultant Neurologist, Research Neurologist)

  5. Basildon and Orsett Hospitals, Essex, UK

    Rudy Capildeo (Consultant Neurologist) (Consultant Neurologist)

Copyright information

© 1984 L. J. Findley, S. Calzetti and L. Cleeves

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Findley, L.J., Calzetti, S., Cleeves, L. (1984). Primidone in essential tremor. In: Findley, L.J., Capildeo, R. (eds) Movement Disorders: Tremor. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06757-2_19

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  • DOI: https://doi.org/10.1007/978-1-349-06757-2_19

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-06759-6

  • Online ISBN: 978-1-349-06757-2

  • eBook Packages: MedicineMedicine (R0)

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