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Analytical Methods in Human Toxicology

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References

  • Ambre, J. J., and Fischer, J. L. (1974). Identification and activity of the hydroxy metabolite that accumulates in the plasma of humans intoxicated with glutethimide. Drug Metab. Dispos. 2, 151–8.

    CAS  PubMed  Google Scholar 

  • Anderson, H. R., Dick, B., Palmer, J. C., and Ramsey, J. D. (1982). Deaths associated with the abuse of volatile substances: an investigation of 140 deaths in the United Kingdom 1971–81. Human Toxicol. 1, 207–21.

    Article  CAS  Google Scholar 

  • Ardrey, R. E., and Moffat, A. C. (1981). Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase. J. Chromatogr. 220, 195–252.

    Article  CAS  PubMed  Google Scholar 

  • Baselt, R. C. (1982). Disposition of Toxic Drugs and Chemicals in Man, 2nd edn. Biomedical Publications, Davis, California.

    Google Scholar 

  • Berry, D. J., and Grove, J. (1973). Emergency toxicological screening for drugs commonly taken in overdose. J. Chromatogr. 80, 205–19.

    Article  CAS  PubMed  Google Scholar 

  • Blacklock, E. C., and Sadler, P. A. (1981). A rapid screening method for heavy metals in biological fluids by emission spectroscopy. Clin. Chim. Acta 113, 89–94.

    Article  Google Scholar 

  • Blackmore, D. J. (1970). The determination of carbon monoxide in blood and tissue. Analyst 95, 439–58.

    Article  CAS  PubMed  Google Scholar 

  • Brown, S. S., Campbell, R. S., Price, C. P., Rambohul, E., Widdøp, B., Barbour, H. M., Roberts, J. G., Burnett, D., Atkinson, T., Scawen, M. D., and Hammond, P. M. (1983). Collaborative trial of an enzyme-based assay for the determination of paracetamol in plasma. Ann. Clin. Biochem. 20, 353–9.

    Article  CAS  PubMed  Google Scholar 

  • Buhl, S. N., Kowalski, P., and Vanderlinde, R. E. (1978). Quantitative toxicology. Interlaboratory and Intermethod Evaluation in New York State. Clin Chem. 24, 442–7.

    CAS  PubMed  Google Scholar 

  • Canalese, J., Gimson, A. E. S., Davis, M., and Williams, R. (1981). Factors contributing to mortality in paracetamol-induced hepatic failure. Br. Med. J. 282, 199–201.

    Article  CAS  Google Scholar 

  • Conard, P. P., Parker, N. C., Cross, R. E., and Wojcieszyn, O. A. (1981). Adaptation of drug enzyme immunoassays to a micro centrifugal analyser. Clin. Chem. 27, 1090.

    Google Scholar 

  • Conference of Medical Royal Colleges (1976). Diagnosis of brain death. Br. Med. J. 2, 1187–8.

    Article  Google Scholar 

  • De Wolff, F. A., Edelbroek, P. M., de Haas, E. J. M., and Vermeij, P. (1983). Experience with a screening method for laxative abuse. Human Toxicol. 2, 385–9.

    Article  Google Scholar 

  • Dijkhuis, I. C. (1979). Quality Control of Drug Assays in Therapy and Toxicology. PhD thesis, University of Leiden, The Netherlands.

    Google Scholar 

  • Epton, J. (1979). Paracetamol: a report of a regional quality control scheme. Ann. Clin. Biochem. 16, 265–70.

    Article  CAS  PubMed  Google Scholar 

  • Flanagan, R. J. (1983). Development and Application of Simple Micro-analytical Techniques in Clinical Toxicology, PhD thesis, University of London.

    Google Scholar 

  • Flanagan, R. J., Huggett, A., Saynor, D. A., Raper, S. M., and Volans, G. N. (1981). Value of toxicological investigations in the diagnosis of acute drug poisoning in children. Lancet ii, 682–5.

    Article  Google Scholar 

  • Flanagan, R. J., Storey, G. C. A., Bhamra, R. K., and Jane, I. (1982). High performance liquid chromatographic analysis of basic drugs on silica columns using non-aqueous ionic eluents. J. Chromatogr. 247, 15–37.

    Article  CAS  Google Scholar 

  • Franke, J. P., Schepers, P., Bosman, J., and de Zeeuw, R. A. (1982). Optimization of thin-layer chromatography for toxicological screening: Applicability of shorter development distances. J. Analyt. Toxicol. 6, 131–4 (see also correction in 7 (1983), 62).

    Article  CAS  Google Scholar 

  • Fry, D. (1981). Lithium-analytical techniques. In Richens, A., and Marks, V. (eds). Therapeutic Drug Monitoring. Churchill Livingstone, Edinburgh, pp. 217.

    Google Scholar 

  • Fysh, R. R., and Jones, L. V. (1980). The screening of pesticides in forensic toxicology. In Oliver, J. S. (ed.), Forensic Toxicology. Croom Helm, London. pp. 189–203.

    Chapter  Google Scholar 

  • Glynn, J. P., and Kendal, S. E. (1975). Paracetamol measurement. Lancet i, 1147–8.

    Article  Google Scholar 

  • Guerrant, G. O., and Hall, C. T. (1977). Drug Abuse Proficiency Testing. Clin. Toxicol. 10, 209–219.

    Article  CAS  PubMed  Google Scholar 

  • Hamlyn, A. N., Brown, A. J., Sherlock, S., and Baron, D. N. (1975). Casual blood-ethanol estimations in patients with chronic liver disease. Lancet ii, 345–7.

    Article  Google Scholar 

  • Helliwell, M., and Berry, D. (1979). Theophylline poisoning in adults. Br. Med. J. 2, 1114.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Helliwell, M., Hampel, G., Sinclair, E., Huggett, A., and Flanagan, R. J. (1979). Value of emergency toxicological investigations in differential diagnosis of coma. Br. Med. J. 2, 819–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huggett, A., Andrews, P., and Flanagan, R. J. (1981). Rapid micro-method for the measurement of paracetamol in blood plasma or serum using gas-liquid chromatography with flame-ionisation detection. J. Chromatogr. 209, 67–76. Idowu, O. R., and Caddy, B. (1982). A review of the use of saliva in the forensic detection of drugs and other chemicals. J. Forens. Sci. Soc. 22, 123–35.

    Google Scholar 

  • Ingelfinger, J. A., Isakson, G., Shine, D., Costello, C. E. and Goldman, P. (1981). Reliability of the toxic screen in drug overdose. Clin. Pharmacol. Ther. 29, 570–75.

    Article  CAS  PubMed  Google Scholar 

  • Jarvie, D. R., and Stewart, M. J. (1979). The rapid extraction of paraquat from plasma using an ion-pairing technique. Clin. Chim. Acta. 94, 241–51.

    Article  CAS  PubMed  Google Scholar 

  • Jick, H. (1977). The discovery of drug-induced illness. N. Engl. J. Med. 296, 481–5.

    Article  CAS  PubMed  Google Scholar 

  • King, M. D., Day, R. E., Oliver, J. S., Lush, M., and Watson, J. M. (1981). Solvent encephalopathy. Br. Med. J. 283, 663–5.

    Article  CAS  Google Scholar 

  • Knepil, J., and Fergie, R. (1980). The fuel cell measurement of blood alcohol. In Oliver, J. S. (ed.), Forensic Toxicology. Croom Helm, London, pp. 95–103.

    Chapter  Google Scholar 

  • Lancet Editorial (1981). Carbon monoxide, an old enemy forgot. Lancet ii, 75–6.

    Google Scholar 

  • Levitt, T. (1979). Determination of paraquat in clinical practice using radioimmunoassay. Proc. Anal. Div. Chem. Soc. 16, 72–6.

    CAS  Google Scholar 

  • Lorber, J., Reckless, J. P. D., and Watson, J. B. G. (1980). Non-accidental poisoning: the elusive diagnosis. Arch. Dis. Childh. 55, 643–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lundquist, F. (1959). Ethyl alcohol in blood and tissues. In Glick, D. (ed.), Methods of Biochemical Analysis. Interscience, New York, vol. 7, p. 217.

    Chapter  Google Scholar 

  • Mace, P. K. K., and Walker, G. (1976). Salicylate interference with plasma-paracetamol method. Lancet ii, 1362.

    Article  Google Scholar 

  • Maehly, A. C. (1967). Volatile toxic compounds. In Stolman, A. (ed.), Progress in Chemical Toxicology. Academic Press, London, pp. 63–98.

    Google Scholar 

  • Marks, V. (1979). Clinical monitoring of therapeutic drugs. Ann. Clin. Biochem 16, 370–9.

    Article  CAS  PubMed  Google Scholar 

  • Meade, B. W., Widdop, B., Blackmore, D. J., Brown, S. S. Curry, A. S., Goulding, R., Higgins, G., Matthew, H. J. S., and Rinsler, M. G. (1972). Simple tests to detect poisons. Ann. Clin. Biochem. 9, 35–46.

    Article  CAS  Google Scholar 

  • Meredith, T. J., and Vale, J. A. (1981). Antidotes. In Vale, J. A., and Meredith, T. J. (eds), Poisoning: Diagnosis and Treatment. Update Books, London, pp. 33–45.

    Chapter  Google Scholar 

  • Michand, J. D., and Jones, D. W. (1980). Thin-layer chromatography for broad spectrum drug detection. Amer. Lab. 12, 104.

    Google Scholar 

  • Moffat, A. C. (ed.) (1985). Clarke’s Isolation and Identification of Drugs, 2nd edn. Pharmaceutical Press, London.

    Google Scholar 

  • Myers, R. E., and Myers, S. E. (1979). Use of sedative, analgesic and anesthetic drugs during labour and delivery: Bane or boon? Amer. J. Obstet. Gynecol. 133, 83–104.

    Article  CAS  Google Scholar 

  • O’Reilly, R. A., and Aggeler, P. M. (1976). Covert anticoagulant ingestion: study of 25 patients and review of world literature. Medicine 55, 389–99.

    Article  PubMed  Google Scholar 

  • Osselton, M. D. (1983). Toxicological tables: A compendium of pharmacological, therapeutic and toxicological data on 136 drugs and chemicals in humans. In Sunshine, I. (ed.), Methodology for Analytical Toxicology, Vol. III. CRC Press, Boca Raton.

    Google Scholar 

  • Parkinson, I. S., Ward, M. K., and Kerr, D. N. S. (1981). Dialysis encephalopathy, bone disease and anaemia: the aluminium syndrome during regular haemodialysis. J. Clin. Pathol., 34, 1285–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pippenger, C. E., Penry, J. K., White, B. G., Daly, D. D., and Buddington, R. (1976). Interlaboratory variability in determination of plasma antiepileptic drug concentrations. Arch. Neurol. 33, 351–5.

    Article  CAS  PubMed  Google Scholar 

  • Pitts, J. (1979). False-positive paracetamol assay. Lancet i, 213–4.

    Article  Google Scholar 

  • Porter, W. H., and Auansakul, A. (1982). Gas-chromatographic determination of ethylene glycol in serum. Clin. Chem. 28, 75–8.

    CAS  PubMed  Google Scholar 

  • Prescott, L. F. (1978). Prevention of hepatic necrosis following paracetamol overdosage. Hlth Bull. 36, 204–12.

    CAS  Google Scholar 

  • Proudfoot, A. T., and Park, J. (1978). Changing pattern of drugs used in self-poisoning. Br. Med. J. 1, 90–93.

    Google Scholar 

  • Proudfoot, A. T., Stewart, M. J., Levitt, T., and Widdop, B. (1979). Paraquat poisoning: significance of plasma paraquat concentrations. Lancet ii, 330–32.

    Article  Google Scholar 

  • Ramsey, J. D., and Flanagan, R. J. (1982). Detection and identification of volatile organic compounds in blood by headspace gas-chromatography as an aid to the diagnosis of solvent abuse. J. Chromatogr. 240, 423–44.

    Article  CAS  PubMed  Google Scholar 

  • Ramsey, J. D., Lee, T. D. Osselton, M. D., and Moffat, A. C. (1980). Gas liquid chromatographic retention indices of 296 non-drug substances on SE-30 or OV-1 likely to be encountered in toxicological analyses. J. Chromatogr. 184, 185–206.

    Article  CAS  PubMed  Google Scholar 

  • Raper, S., Crome, P., Vale, J. A., Helliwell, M., and Widdop, B. (1982). Experience with activated carbon-bead haemoperfusion columns in the treatment of severe drug intoxication: a preliminary report. Arch. Toxicol. 49, 303–310.

    Article  CAS  PubMed  Google Scholar 

  • Ratcliffe, W. A., Fletcher, S. M., Moffat, A. C., Ratcliffe, J. G., Harland, W. A., and Levitt, T. E. (1977). Radioimmunoassay of lysergic acid diethylamide (LSD) in serum and urine by using antisera of different specificities. Clin. Chem. 23, 169–74.

    CAS  PubMed  Google Scholar 

  • Robinson, C. A., Scott, J. W., and Ketchum, C. (1983). Propylene glycol interference with ethylene glycol procedures. Clin. Chem. 29, 727.

    CAS  PubMed  Google Scholar 

  • Rogers, D., Tripp, J., Bentovim, A., Robinson, A., Berry, D., and Goulding, R. (1976). Non-accidental poisoning: an extended syndrome of child abuse. Br. Med. J. 1, 793–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rutterford, M. G., and Smith, R. N. (1980). Radioimmunoassay of diazepam in samples of forensic interest. J. Pharm. Pharmacol. 32, 449–52.

    Article  CAS  PubMed  Google Scholar 

  • Schepers, P., Wijsbeek, J., Franke, J. P., and de Zeeuw, R. A. (1982). Applicability of capillary gas-chromatography to substance identification in toxicology by means of retention indices. J. Forens. Sci. 27, 49–60.

    Article  CAS  Google Scholar 

  • Sohn, D. (1977). The College of American Pathologists Toxicology Program. J. Analyt. Toxicol. 1, 111–7.

    Article  CAS  Google Scholar 

  • Stead, A. H., Gill, R., Wright, T., Gibbs, J. P., and Moffat, A. C. (1982). Standardised thin-layer chromatographic systems for the identification of drugs and poisons. Analyst (Lond.) 107, 1106–68.

    Article  CAS  Google Scholar 

  • Stewart, M. J., Adriaenssens, P. I., Jarvie, D. R., and Prescott, L. F. (1979). Inappropriate methods for the emergency determination of plasma paracetamol. Ann. Clin. Biochem. 16, 89–95.

    Article  CAS  PubMed  Google Scholar 

  • Sutheimer, C., Hepler, B. R. and Sunshine, I. (1982). Clinical application and evaluation of the EMIT-St TM drug detection system. Amer. J. Clin. Pathol. 77, 731–5.

    Article  CAS  Google Scholar 

  • Taylor, W. T., Finn, A. L., and Gotcher, S. (eds) (1981). Individualizing Drug Therapy: Clinical Notes on the Application of Drug Monitoring. Gross, Townsend, Frank; New York (available from Syva).

    Google Scholar 

  • Teale, J. D., Forman, E. J., King, L. J., and Marks, V. (1974). Radioimmunoassay of cannabinoids in blood and urine. Lancet ii, 553–5.

    Article  Google Scholar 

  • Thompson, N., and Henry, J. A. (1983). Carbon monoxide poisoning: Poisons Unit experience over five years. Human Toxicol. 2, 335–8.

    Article  CAS  Google Scholar 

  • Trinder, P. (1954). Rapid determination of salicylate in biological fluids. Biochem. J. 57, 301–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vale, J. A., and Meredith, T. J. (1981). Epidemiology of poisoning in the U.K. In Vale, J. A., and Meredith, T. J. (eds), Poisoning: Diagnosis and Treatment. Update Books, London, pp. 1–8.

    Chapter  Google Scholar 

  • Vale, J. A., Prior, J. G., O’Hare, J. P., Flanagan, R. J., and Feehally, J. (1982). Treatment of ethylene glycol poisoning with peritoneal dialysis. Br. Med. J. 284, 557.

    Article  CAS  Google Scholar 

  • Vanzeiti, G., Cassani, M., and Valente, D. (1983). Detection of morphine in urine by hemagglutination inhibition, with use of lyophilised reagents. Clin. Chem. 29, 1376–9.

    Google Scholar 

  • Walberg, C. B. (1981). An ultraviolet spectrophotometric procedure for differentiation and quantitation of barbiturates. Clin. Toxicol. 18, 879–86.

    Article  CAS  PubMed  Google Scholar 

  • Wheals, B. B. (1980). Isocratic multi-column high performance liquid chromatography as a technique for qualitative analysis and its application to the characterisation of basic drugs using an aqueous methanol solvent. J. Chromatogr. 187, 65–85.

    Article  CAS  PubMed  Google Scholar 

  • Widdop, B. (1974). Drug analysis in the overdosed patient. In The Poisoned Patient: The Role of the Laboratory. Ciba Foundation Symposium 26 (New Series), Associated Scientific Publishers, Amsterdam, pp. 219–38.

    Google Scholar 

  • Widdop, B. (1976). Detection of paraquat in urine. Br. Med. J. 2, 1135.

    Google Scholar 

  • Widdop, B. (1980). Screening for drugs of abuse: application of Tox-Elut columns. In A. Kovatsis (ed.), Toxicological Aspects (Proceedings of the 9th International Congress of the European Association of Poison Control Centres). Thessalonika, pp. 231–9.

    Google Scholar 

  • Widdop, B. (1982). In Kaiser, E. et al. (eds), Applications of Toxicological Analyses in the Diagnosis and Management of Poisoning. XIth International Congress of Clinical Chemistry. de Gruyter, Berlin and New York, pp. 911–9.

    Google Scholar 

  • Widdop, B. (1985). Hospital Toxicology. In Moffat, A. C. (ed.), Clarke’s Isolation and Identification of Drugs, 2nd edn. Pharmaceutical Press, London.

    Google Scholar 

  • Wilson, J. T., Brown, R. D., Cherek, D. R., Dailey, J. W., Hilman, B., Jobe, P. C., Manno, B. R., Manno, J. E., Redetzki, H. M., and Stewart, J. J. (1980). Drug excretion in human breast milk: Principles, pharmacokinetics and projected consequences. Clin. Pharmacokinet. 5, 1–66.

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. R. J. Flanagan
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  2. B. Widdop
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A. S. Curry

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Flanagan, R.J., Widdop, B. (1984). Clinical Toxicology. In: Curry, A.S. (eds) Analytical Methods in Human Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06715-2_2

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